Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Mala R. Chinoy"'
Publikováno v:
Journal of Surgical Research. 124:14-22
Background A major pathological finding in human newborns with pulmonary hypoplasia and congenital diaphragmatic hernia is the presence of vascular abnormalities in lungs. Vasculogenesis/angiogenesis are crucial to lung development. To study lung alv
Publikováno v:
Journal of Surgical Research. 123:153-157
The number of Ph.D. faculty in clinical departments now exceeds the number of Ph.D. faculty in basic science departments. Given the escalating pressures on academic surgeons to produce in the clinical arena, the recruitment and retention of high-qual
Autor:
MaryAnn V. Volpe, Terrigi J Ciccone, Mala R. Chinoy, Heber C. Nielsen, Kwanchai Archavachotikul
Publikováno v:
Molecular Genetics and Metabolism. 80:242-254
We recently showed that T3 treatment of cultured gestational day 11.5 early pseudoglandular period mouse lungs, accelerated terminal airway development at the expense of decreased branching morphogenesis. As the ability of T3 to influence epithelial
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L60-L66
We hypothesized that exposure of murine fetuses to environmental toxins, such as nitrofen, during early embryogenesis alters vasculogenesis. To address our hypothesis, we assessed protein levels of endothelial cell-selective angiogenic factors: angio
Publikováno v:
Pediatric Pulmonology. 32:129-141
We compared proliferation (growth) and differentiation (development) related proteins in normal and hypoplastic fetal murine lungs. The hypoplastic lungs were created in CD-1 fetal mice by nitrofen exposure (25 mg per pregnant mouse given intragastri
Publikováno v:
Journal of Surgical Research. 93:108-119
Small Cell Lung Cancer (SCLC), a clinically aggressive cancer, accounts for approximately 25% of primary lung cancers. We carried out suppression subtractive hybridization (SSH), a PCR-based method for cDNA subtraction, between the human classic, NCI
Publikováno v:
Molecular and Cellular Biochemistry. 212:121-129
Altered regulation of cAMP may contribute to enhanced renal reactivity to angiotensin II (Ang II) in spontaneously hypertensive rats (SHR). Such a phenomenon may occur in renal preglomerular arterioles and may involve changes in expression of GTP-bin
Autor:
Li Zhang, Rachel A. Causak, Steven E. Zgleszewski, Robert E. Cilley, Mala R. Chinoy, Thomas M. Krummel
Publikováno v:
Pediatric Pulmonology. 26:301-311
The purpose of this study was to identify differentially expressed genes in normal and nitrofen-induced hypoplastic lungs in fetal mice. Such genes may play a role in the regulation of lung development. CD-1 pregnant dams were gavaged with 25 mg of n
Autor:
Christopher J. Blewett, Mala R. Chinoy, Steven E. Zgleszewski, Robert E. Cilley, Thomas M. Krummel
Publikováno v:
Journal of Pediatric Surgery. 33:433-441
The authors hypothesized that increased intraluminal pressure in the fetal stomach would enhance development in a murine organ culture model.Gestation day 14 (Gd14) fetal stomachs from time-dated pregnant CD-1 mice (term, 20 days) were maintained in
Autor:
Steven E. Zgleszewski, Mala R. Chinoy, Robert E. Cilley, Thomas M. Krummel, Christopher J. Blewett
Publikováno v:
Journal of Pediatric Surgery. 31:869-877
Evidence exists from both congenital anomalies and animal models that normal fetal lung development is dependent on maintenance of fluid pressure within the developing "airways." Fetal tracheostomy, allowing free egress of airway fluids, results in l