Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Mal-Gi Choi"'
Autor:
Tu Anh Nguyen, Trang Hoang, Thu-Thuy Nguyen, ChanSu Jeong, Trang Van Tran, Mal-Gi Choi, ChangWoo Lee
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0308370 (2024)
Human hyaluronidase 1 (HYAL1) and PH20 play vital roles in degrading hyaluronic acids through the substrate-assisted double displacement mechanism. While HYAL1, a lysosomal enzyme, functions optimally under acidic conditions, PH20, a sperm surface hy
Externí odkaz:
https://doaj.org/article/ed164a1afa0f43d8b2de2af29f67744a
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195339 (2018)
α-Synuclein (α-syn) is a major component of Lewy bodies found in synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Under the pathological conditions, α-syn tends to generate a diverse form of aggregates show
Externí odkaz:
https://doaj.org/article/085c428fcff9494ba025fc250342b90a
Publikováno v:
Journal of the American Chemical Society. 135:10254-10257
Current single-molecule techniques do not permit the real-time observation of multiple proteins interacting closely with each other. We here report an approach enabling us to determine the single-molecule fluorescence resonance energy transfer (FRET)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d166ee6655c310355d88a1f157cb82f
https://doi.org/10.1021/ja404276g
https://doi.org/10.1021/ja404276g
Autor:
Dae-Hyuk Kweon, Mal-Gi Choi, Yeon-Kyun Shin, Nam Ki Lee, Jae-Yeol Kim, Ying Lai, Bong-Kyu Choi, Yoosoo Yang
Publikováno v:
Proceedings of the National Academy of Sciences. 110:4087-4092
Parkinson disease and dementia with Lewy bodies are featured with the formation of Lewy bodies composed mostly of α-synuclein (α-Syn) in the brain. Although evidence indicates that the large oligomeric or protofibril forms of α-Syn are neurotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77eaab08db7fed2ff8f9bbc293b9b920
https://doi.org/10.1073/pnas.1218424110
https://doi.org/10.1073/pnas.1218424110
Publikováno v:
The EMBO Journal. 31:2144-2155
Synaptotagmin-1 (Syt1) is a major Ca2+ sensor for synchronous neurotransmitter release, which requires vesicle fusion mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors). Syt1 utilizes its diverse interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a596f2448196e64734a8b5651f452854
https://doi.org/10.1038/emboj.2012.57
https://doi.org/10.1038/emboj.2012.57
Publikováno v:
BMB Reports. 44:458-461
Enteropeptidase is a serine protease secreted by the pancreas and converts inactive trypsinogen to active trypsin. Enteropeptidase cleaves the C-terminal end of the substrate recognition sequence Asp-Asp-Asp-Asp-Lys (D(4)K). The assay for enteropepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b7a1f32d1c98c378c54366ca5db725
https://doi.org/10.5483/bmbrep.2011.44.7.458
https://doi.org/10.5483/bmbrep.2011.44.7.458
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 4, p e0195339 (2018)
PLoS ONE, Vol 13, Iss 4, p e0195339 (2018)
α-Synuclein (α-syn) is a major component of Lewy bodies found in synucleinopathies including Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB). Under the pathological conditions, α-syn tends to generate a diverse form of aggregates show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e3fb798f5f15585d019070b8fa7e94
https://doi.org/10.1371/journal.pone.0195339
https://doi.org/10.1371/journal.pone.0195339
Autor:
Sumana Raychaudhuri, Timothy A. Schulz, Rodolfo Ghirlando, Jason A. Mears, William A. Prinz, Mal Gi Choi, Jenny E. Hinshaw
Publikováno v:
The Journal of Cell Biology
The ORP lipid-binding domain can contact two membranes simultaneously to facilitate sterol extraction or delivery at one membrane in response to the lipid composition of the other.
Sterols are transferred between cellular membranes by vesicular
Sterols are transferred between cellular membranes by vesicular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca68a2f2924e611916fe7b76bdef2702
http://europepmc.org/articles/PMC2806323
http://europepmc.org/articles/PMC2806323
Publikováno v:
Journal of Biological Chemistry. 280:26105-26112
The Saccharomyces cerevisiae CKI1-encoded choline kinase catalyzes the committed step in phosphatidylcholine synthesis via the Kennedy pathway. The enzyme is phosphorylated on multiple serine residues, and some of this phosphorylation is mediated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9150fdd9b24b71a80048adcbbfe36729
https://doi.org/10.1074/jbc.m503551200
https://doi.org/10.1074/jbc.m503551200
Publikováno v:
Biophysical Journal. 104(2)
Synaptotagmin 1 (Syt1) is thought to be the main Ca2+ switch for the presynaptic vesicle fusion. Although in vitro fusion assays importantly contributed to understanding the molecular mechanism of Syt1, the results was largely restricted to truncated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330c1846af79871e7312df64d4bd4749