Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Maksym V Kopanitsa"'
Autor:
Esperanza Fernández, Mark O Collins, Rachel T Uren, Maksym V Kopanitsa, Noboru H Komiyama, Mike D R Croning, Lysimachos Zografos, J Douglas Armstrong, Jyoti S Choudhary, Seth G N Grant
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-17 (2009)
Abstract The molecular complexity of mammalian proteomes demands new methods for mapping the organization of multiprotein complexes. Here, we combine mouse genetics and proteomics to characterize synapse protein complexes and interaction networks. Ne
Externí odkaz:
https://doaj.org/article/c27f02bf9974478d9f00312f01fea918
Autor:
Esperanza Fernández, Mark O. Collins, René A.W. Frank, Fei Zhu, Maksym V. Kopanitsa, Jess Nithianantharajah, Sarah A. Lemprière, David Fricker, Kathryn A. Elsegood, Catherine L. McLaughlin, Mike D.R. Croning, Colin Mclean, J. Douglas Armstrong, W. David Hill, Ian J. Deary, Giulia Cencelli, Claudia Bagni, Menachem Fromer, Shaun M. Purcell, Andrew J. Pocklington, Jyoti S. Choudhary, Noboru H. Komiyama, Seth G.N. Grant
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 679-691 (2017)
Arc is an activity-regulated neuronal protein, but little is known about its interactions, assembly into multiprotein complexes, and role in human disease and cognition. We applied an integrated proteomic and genetic strategy by targeting a tandem af
Externí odkaz:
https://doaj.org/article/75279cd7ad9f46f593bed20c4b72bd92
Autor:
Sean McKay, Tomás J. Ryan, Jamie McQueen, Tim Indersmitten, Katie F.M. Marwick, Philip Hasel, Maksym V. Kopanitsa, Paul S. Baxter, Marc-André Martel, Peter C. Kind, David J.A. Wyllie, Thomas J. O’Dell, Seth G.N. Grant, Giles E. Hardingham, Noboru H. Komiyama
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 841-851.e4 (2018)
Summary: The GluN2 subtype (2A versus 2B) determines biophysical properties and signaling of forebrain NMDA receptors (NMDARs). During development, GluN2A becomes incorporated into previously GluN2B-dominated NMDARs. This “switch” is proposed to
Externí odkaz:
https://doaj.org/article/dd3ab73865074c9fa7090b212b99cf6f
Autor:
Tuukka O. Piiponniemi, Teija Parkkari, Taneli Heikkinen, Jukka Puoliväli, Larry C. Park, Roger Cachope, Maksym V. Kopanitsa
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Cognitive disturbances often predate characteristic motor dysfunction in individuals with Huntington’s disease (HD) and place an increasing burden on the HD patients and caregivers with the progression of the disorder. Therefore, application of max
Externí odkaz:
https://doaj.org/article/d214211a342943adb309c47625f378d5
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 9665, p 9665 (2021)
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 9665, p 9665 (2021)
Volume 22
Issue 18
The paucity of currently available therapies for glioblastoma multiforme requires novel approaches to the treatment of this brain tumour. Disrupting cyclic nucleotide-signalling through phosphodiesterase (PDE) inhibition may be a promising way of sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0986a96083992b2619e85db3e9cd3a2
Autor:
Hilde Brems, Maksym V. Kopanitsa, Alexa E. Horner, Akihiko Yoshimura, Sarah C. Borrie, Eric Legius
Publikováno v:
Genes, Brain and Behavior. 20
RASopathies are neuro-cardio-facio-cutaneous disorders stemming from mutations in genes regulating the RAS-MAPK pathway. Legius syndrome is a rare RASopathy disorder caused by mutations in the SPRED1 gene. SPRED1 protein negatively regulates activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca33fbaf7f51a8a97967238f606fa361
https://doi.org/10.1111/gbb.12727
https://doi.org/10.1111/gbb.12727
Aging is a complex process that differentially impacts multiple cognitive, sensory, neuronal and molecular processes. Technological innovations now allow for parallel investigation of neuronal circuit function, structure and molecular composition in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84151f8918c32227371679b91d7521f3
http://hdl.handle.net/10044/1/86592
http://hdl.handle.net/10044/1/86592
Autor:
Alexa E. Horner, Robbie McLaren-Jones, Jess Nithianantharajah, Rebecca H. C. Norris, Maksym V. Kopanitsa, Liam Alexander, Seth G. N. Grant, Noboru H. Komiyama
Publikováno v:
Genes, Brain and Behavior. 20
The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved multiprotein complex that comprises neurotransmitter receptors, cell-adhesion molecules, scaffold proteins and enzymes, which are essential for brain signalling a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7d860cf88789eba560d96dbae4c10d4
https://doi.org/10.1111/gbb.12723
https://doi.org/10.1111/gbb.12723
Autor:
Nawal Zabouri, Samuel J. Barnes, Pavlina Pavlidi, Joseph Airey, Takaomi C. Saido, Leire Melgosa-Ecenarro, Carola I. Radulescu, Maksym V. Kopanitsa, Nazanin Doostdar, Takashi Saito
Publikováno v:
Cell calcium. 95
The adult neocortex is not hard-wired but instead retains the capacity to reorganise across multiple spatial scales long into adulthood. Plastic reorganisation occurs at the level of mesoscopic sensory maps, functional neuronal assemblies and synapti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f7b7d9f02b2767d291b6e5e1ad0d34
https://pubmed.ncbi.nlm.nih.gov/33610083
https://pubmed.ncbi.nlm.nih.gov/33610083
Autor:
Alexa E, Horner, Rebecca H, Norris, Robbie, McLaren-Jones, Liam, Alexander, Noboru H, Komiyama, Seth G N, Grant, Jess, Nithianantharajah, Maksym V, Kopanitsa
Publikováno v:
Genes, brain, and behaviorREFERENCES. 20(1)
The postsynaptic terminal of vertebrate excitatory synapses contains a highly conserved multiprotein complex that comprises neurotransmitter receptors, cell-adhesion molecules, scaffold proteins and enzymes, which are essential for brain signalling a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bafe81d968fd296596289f5dc457e84b
https://pubmed.ncbi.nlm.nih.gov/33347690
https://pubmed.ncbi.nlm.nih.gov/33347690