Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Maksimainen, M. M. (Mirko M.)"'
Autor:
Sowa, S. T. (Sven T.), Galera-Prat, A. (Albert), Wazir, S. (Sarah), Alanen, H. I. (Heli I.), Maksimainen, M. M. (Mirko M.), Lehtiö, L. (Lari)
Here, we describe a protocol to set up a screening assay for ADP-ribosyl binding proteins including proteins that possess O-glycosidase or N-glycosidase activities. The FRET-based assay measures the interaction of any ADP-ribosyl binding protein fuse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::ffcffe53e477a403c6f155d321a9a3cb
http://urn.fi/urn:nbn:fi-fe2022051335061
http://urn.fi/urn:nbn:fi-fe2022051335061
Autor:
Nizi, M. G. (Maria Giulia), Maksimainen, M. M. (Mirko M.), Lehtiö, L. (Lari), Tabarrini, O. (Oriana)
Major advances have recently defined functions for human mono-ADP-ribosylating PARP enzymes (mono-ARTs), also opening up potential applications for targeting them to treat diseases. Structural biology combined with medicinal chemistry has allowed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::931ab546f300b4025bf5d07847776bfa
http://urn.fi/urn:nbn:fi-fe2022121671984
http://urn.fi/urn:nbn:fi-fe2022121671984
Autor:
Maksimainen, M. M. (Mirko M.), Murthy, S. (Sudarshan), Sowa, S. T. (Sven T.), Galera-Prat, A. (Albert), Rolina, E. (Elena), Heiskanen, J. P. (Juha P.), Lehtiö, L. (Lari)
The scaffold of TIQ-A, a previously known inhibitor of human poly-ADP-ribosyltransferase PARP1, was utilized to develop inhibitors against human mono-ADP-ribosyltransferases through structure-guided design and activity profiling. By supplementing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::ddc82de522ae78b91197d7dd9ebde924
http://urn.fi/urn:nbn:fi-fe2021122061784
http://urn.fi/urn:nbn:fi-fe2021122061784
Autor:
Sowa, S. T. (Sven T.), Galera-Prat, A. (Albert), Wazir, S. (Sarah), Alanen, H. I. (Heli I.), Maksimainen, M. M. (Mirko M.), Lehtiö, L. (Lari)
Summary Proteins interacting with ADP-ribosyl groups are often involved in disease-related pathways or viral infections, making them attractive drug targets. We present a robust and accessible assay applicable to both hydrolyzing or non-hydrolyzing b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::532768eec016026fd9fb426206f2fe0a
http://urn.fi/urn:nbn:fi-fe2021121761679
http://urn.fi/urn:nbn:fi-fe2021121761679
Autor:
Korn, P. (Patricia), Classen, A. (Arno), Murthy, S. (Sudarshan), Guareschi, R. (Riccardo), Maksimainen, M. M. (Mirko M.), Lippok, B. E. (Barbara E.), Galera-Prat, A. (Albert), Sowa, S. T. (Sven T.), Voigt, C. (Catharina), Rossetti, G. (Giulia), Lehtiö, L. (Lari), Bolm, C. (Carsten), Lüscher, B. (Bernhard)
Intracellular ADP-ribosyltransferases catalyze mono- and poly-ADP-ribosylation and affect a broad range of biological processes. The mono-ADP-ribosyltransferase PARP10 is involved in signaling and DNA repair. Previous studies identified OUL35 as a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::12565d8689a8a34987d5af4c618e348f
http://urn.fi/urn:nbn:fi-fe2021121761478
http://urn.fi/urn:nbn:fi-fe2021121761478
Autor:
Maksimainen, M. M. (Mirko M.), Nurmesjärvi, A. (Antti), Terho, R. A. (Reima A.), Threadgill, M. D. (Michael D.), Lehtiö, L. (Lari), Heiskanen, J. P. (Juha P.)
Thieno[2,3-c]isoquinolin-5(4H)-one is known for its potential as an anti-ischemic agent through the inhibition of poly(ADP-ribose) polymerase 1 (PARP1). However, the compound also inhibits many other enzymes of the PARP family, potentially limiting i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::c1e18d883e0301162eeff2e9795cd29e
http://urn.fi/urn:nbn:fi-fe2020060139986
http://urn.fi/urn:nbn:fi-fe2020060139986
Synaptic adhesion molecules, including presynaptic neurexins (NRXNs) and post-synaptic leucine-rich repeat transmembrane (LRRTM) proteins are important for development and maintenance of brain neuronal networks. NRXNs are probably the best characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::60bc4502aef25205a649ae5498a970a8
http://urn.fi/urn:nbn:fi-fe202002044535
http://urn.fi/urn:nbn:fi-fe202002044535
Autor:
Kiema, T.-R. (Tiila-Riikka), Thapa, C. J. (Chandan J.), Laitaoja, M. (Mikko), Schmitz, W. (Werner), Maksimainen, M. M. (Mirko M.), Fukao, T. (Toshiyuki), Rouvinen, J. (Juha), Jänis, J. (Janne), Wierenga, R. K. (Rik K.)
The SCP2 (sterol carrier protein 2)-thiolase (type-1) functions in the vertebrate peroxisomal, bile acid synthesis pathway, converting 24-keto-THC-CoA and CoA into choloyl-CoA and propionyl-CoA. This conversion concerns the β-oxidation chain shorten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2423::2256691df3ef711eba05b75c6a41701c
http://www.biochemj.org/content/476/2/307.supplemental
http://www.biochemj.org/content/476/2/307.supplemental