Deep sequencing of the nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease

Autor: Kathryn Lord, Simon Lovestone, Michelle K. Lupton, Bruno Vellas, Patrizia Mecocci, Richard Wroe, Gillian Hamilton, John Powell, Makrina Danillidou, Denise Harold, Magda Tsolaki, Hilkka Soininen, Megan Pritchard, Paul Hollingworth, Iwona Kłoszewska, Petroula Proitsi, Belinda M. Martin

Publikováno v: Lupton, M K, Proitsi, P, Danillidou, M, Tsolaki, M, Hamilton, G, Wroe, R, Pritchard, M, Lord, K, Martin, B M, Kloszewska, I, Soininen, H, Mecocci, P, Vellas, B, Harold, D, Hollingworth, P, Lovestone, S & Powell, J F 2011, ' Deep Sequencing of the Nicastrin Gene in Pooled DNA, the Identification of Genetic Variants That Affect Risk of Alzheimer's Disease ', PLoS ONE, vol. 6, no. 2, e17298, pp.-. https://doi.org/10.1371/journal.pone.0017298
King's College London
PLoS ONE, Vol 6, Iss 2, p e17298 (2011)
PLoS ONE
PLoS ONE; Vol 6

Nicastrin is an obligatory component of the c-secretase; the enzyme complex that leads to the production of Ab fragments critically central to the pathogenesis of Alzheimer's disease (AD). Analyses of the effects of common variation in this gene on r

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https://orca.cardiff.ac.uk/id/eprint/80475/1/journal.pone.0017298.pdf