Co-Administration of Anticancer Candidate MK-2206 Enhances the Efficacy of BCG Vaccine Against Mycobacterium tuberculosis in Mice and Guinea Pigs

Autor: Rania Bouzeyen, Saurabh Chugh, Tannu Priya Gosain, Mohamed-Ridha Barbouche, Meriam Haoues, Kanury V. S. Rao, Makram Essafi, Ramandeep Singh

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

The failure of M. bovis BCG to induce long-term protection has been endowed to its inability to escape the phagolysosome, leading to mild activation of CD8+ mediated T cell response. Induction of apoptosis in host cells plays an important role in pot

Externí odkaz: https://doaj.org/article/ffaa4ea1e899451aad6a467a6a8a48ab

Mycobacterium tuberculosis Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 Phenotype

Autor: Amira Refai, Sami Gritli, Mohamed-Ridha Barbouche, Makram Essafi

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)

Tuberculosis, a human infectious disease caused by Mycobacterium tuberculosis (M.tb), is still a major cause of morbidity and mortality worldwide. The success of M.tb as a pathogen relies mainly on its ability to divert the host innate immune respons

Externí odkaz: https://doaj.org/article/c4ae272f7f3f41408fd73ecc9ba5374d

Co-Administration of Anticancer Candidate MK-2206 Enhances the Efficacy of BCG Vaccine Against Mycobacterium tuberculosis in Mice and Guinea Pigs

Autor: Tannu Priya Gosain, Ramandeep Singh, Saurabh Chugh, Rania Bouzeyen, Mohamed-Ridha Barbouche, Meriam Haoues, Kanury V S Rao, Makram Essafi

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology

The failure of M. bovis BCG to induce long-term protection has been endowed to its inability to escape the phagolysosome, leading to mild activation of CD8+ mediated T cell response. Induction of apoptosis in host cells plays an important role in pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2410a6ad728c222543716344d34efd3
https://www.frontiersin.org/articles/10.3389/fimmu.2021.645962/full

Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness.

Autor: Khadija Essafi-Benkhadir, Sébastien Grosso, Alexandre Puissant, Guillaume Robert, Makram Essafi, Marcel Deckert, Emmanuel Chamorey, Olivier Dassonville, Gérard Milano, Patrick Auberger, Gilles Pagès

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4478 (2009)

BackgroundThe ambiguous role of transcription factor Sp3 for tumour progression is still debated since it was described as a transcriptional repressor or activator. Here we tried to decipher the molecular mechanisms implicated in Sp3 accumulation obs

Externí odkaz: https://doaj.org/article/8f9e91c49ae54cd29cd0fa7d34e258ec

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

Autor: Houcemeddine Othman, Ichrak Riahi-Chebbi, Meriam Haoues, Soumaya Souid, Makram Essafi, Habib Karoui, Alain Morel, Najet Srairi-Abid, Khadija Essafi-Benkhadir

Publikováno v: Scientific Reports
Scientific Reports, 2019, 9 (1), pp.195. ⟨10.1038/s41598-018-36808-z⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.195. ⟨10.1038/s41598-018-36808-z⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-20 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-018-36808-z⟩

International audience; Resistance to 5-Fluorouracil chemotherapy is a major cause of therapeutic failure in colon cancer cure. Development of combined therapies constitutes an effective strategy to inhibit cancer cells and prevent the emergence of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe4d305a6ceab17fdce5c982785b621
https://www.hal.inserm.fr/inserm-02097051