Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Makoto Tsunozaki"'
Autor:
Kristin A Gerhold, Maurizio Pellegrino, Makoto Tsunozaki, Takeshi Morita, Duncan B Leitch, Pamela R Tsuruda, Rachel B Brem, Kenneth C Catania, Diana M Bautista
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55001 (2013)
Little is known about the molecular mechanisms underlying mammalian touch transduction. To identify novel candidate transducers, we examined the molecular and cellular basis of touch in one of the most sensitive tactile organs in the animal kingdom,
Externí odkaz:
https://doaj.org/article/ce1a847040494c3ea49d59e6e3fe57e0
Autor:
Diana M. Bautista, Makoto Tsunozaki, Cheryl L. Stucky, Samata Katta, Daniel Vilceanu, Richard C. Lennertz
Publikováno v:
The Journal of Physiology. 591:3325-3340
Key points • Extracts from the toothache tree (Zanthoxylum) are used to treat inflammatory pain, such as toothache and arthritis. • Hydroxy-α-sanshool (sanshool) is a major alkylamide in extracts from Zanthoxylum plants. • Sanshool treatment i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42146f3095afd78a89550bc45c5bd393
https://doi.org/10.1113/jphysiol.2013.252106
https://doi.org/10.1113/jphysiol.2013.252106
Publikováno v:
Annual Review of Physiology. 75:181-200
Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli, tissue repair, and protective behaviors to prevent further damage and encourage healing. However, inflammation may outlive its usefulness and become chronic.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ca7a719ba0658611aa8e0b02804af4
https://doi.org/10.1146/annurev-physiol-030212-183811
https://doi.org/10.1146/annurev-physiol-030212-183811
Publikováno v:
Nature
Nature, vol 472, iss 7343
Nature, vol 472, iss 7343
Innate behaviours are flexible: they change rapidly in response to transient environmental conditions, and are modified slowly by changes in the genome. A classical flexible behaviour is the exploration-exploitation decision, which describes the time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2dac214d10f203f549159d80236935
https://doi.org/10.1038/nature09821
https://doi.org/10.1038/nature09821
Publikováno v:
The Journal of Neuroscience. 30:4353-4361
Hydroxy-α-sanshool, the active ingredient in plants of the prickly ash plant family, induces robust tingling paresthesia by activating a subset of somatosensory neurons. However, the subtypes and physiological function of sanshool-sensitive neurons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10397c9c9d9a5754b36fab3aa030a8e0
https://doi.org/10.1523/jneurosci.4666-09.2010
https://doi.org/10.1523/jneurosci.4666-09.2010
Autor:
Makoto Tsunozaki, Diana M. Bautista
Publikováno v:
Current Opinion in Neurobiology. 19:362-369
In the mammalian somatosensory system, mechanosensitive neurons mediate the senses of touch and pain. Among sensory modalities, mechanosensation has been the most elusive with regard to the identification of transduction molecules. One factor that ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a239ff3ba90f52e09ba53bdc7c2d954
https://doi.org/10.1016/j.conb.2009.07.008
https://doi.org/10.1016/j.conb.2009.07.008
Publikováno v:
Neuron. 59:959-971
Summary Innate chemosensory preferences are often encoded by sensory neurons that are specialized for attractive or avoidance behaviors. Here, we show that one olfactory neuron in Caenorhabditis elegans, AWC ON , has the potential to direct both attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3899811a66df19422b14f20435e90131
https://doi.org/10.1016/j.neuron.2008.07.038
https://doi.org/10.1016/j.neuron.2008.07.038
Publikováno v:
Proceedings of the National Academy of Sciences. 99:775-779
Early embryonic cells in Caenorhabditis elegans embryos interact through a signaling pathway closely related to the Notch signaling pathway in Drosophila and vertebrates.Components of this pathway include a ligand, receptor, the presenilin proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b3ab51359549482b8db59da181b30a
https://doi.org/10.1073/pnas.022523499
https://doi.org/10.1073/pnas.022523499
Autor:
Makoto, Tsunozaki, Richard C, Lennertz, Daniel, Vilceanu, Samata, Katta, Cheryl L, Stucky, Diana M, Bautista
Publikováno v:
The Journal of physiology. 591(13)
In traditional medicine, the ‘toothache tree’ and other plants of the Zanthoxylum genus have been used to treat inflammatory pain conditions, such as toothache and rheumatoid arthritis. Here we examined the cellular and molecular mechanisms under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efac7fb145c7f9c8b01f52abb7e68f22
https://pubmed.ncbi.nlm.nih.gov/23652591
https://pubmed.ncbi.nlm.nih.gov/23652591
Autor:
Daniel Ramot, Cornelia I. Bargmann, Nikos Chronis, Miriam B. Goodman, Makoto Tsunozaki, Jesse M. Gray, Sreekanth H. Chalasani
Publikováno v:
Nature. 533:130-130
Nature 450, 63–70 (2007); doi:10.1038/nature06292 corrigendum Nature 451, 102 (2008); doi:10.1038/nature06540 We have discovered that Figs 1, 2, 3 and 5 and Supplementary Figs 1–5 and 7 of this Article were generated from calcium imaging data tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae59e5a22656640ac2c48b5791ae9f91
https://doi.org/10.1038/nature16515
https://doi.org/10.1038/nature16515