Zobrazeno 1 - 10
of 611
pro vyhledávání: '"Makoto Tominaga"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Transient Receptor Potential Vanilloid 1 (TRPV1) plays a central role in pain sensation and is thus an attractive pharmacological drug target. SAF312 is a potent, selective, and non-competitive antagonist of TRPV1 and shows promising potenti
Externí odkaz:
https://doaj.org/article/76f10ec5075d4ea089d0013dab1fd995
Autor:
Takuto Suito, Makoto Tominaga
Publikováno v:
Frontiers in Neural Circuits, Vol 18 (2024)
Thermoregulation is a fundamental mechanism for maintaining homeostasis in living organisms because temperature affects essentially all biochemical and physiological processes. Effector responses to internal and external temperature cues are critical
Externí odkaz:
https://doaj.org/article/b4e145d0288b43fd98ebf4d3e47fbc7f
Autor:
Makiko Kashio, Sandra Derouiche, Reiko U Yoshimoto, Kenji Sano, Jing Lei, Mizuho A Kido, Makoto Tominaga
Publikováno v:
eLife, Vol 13 (2024)
Reports indicate that an interaction between TRPV4 and anoctamin 1 (ANO1) could be widely involved in water efflux of exocrine glands, suggesting that the interaction could play a role in perspiration. In secretory cells of sweat glands present in mo
Externí odkaz:
https://doaj.org/article/d9ce1831558c4c3baaa64943c4ef29c8
Autor:
Junping Fan, Chang Guo, Daohong Liao, Han Ke, Jing Lei, Wenjun Xie, Yuliang Tang, Makoto Tominaga, Zhuo Huang, Xiaoguang Lei
Publikováno v:
Advanced Science, Vol 11, Iss 25, Pp n/a-n/a (2024)
Abstract The nonselective calcium‐permeable Transient Receptor Potential Cation Channel Subfamily V Member4 (TRPV4) channel regulates various physiological activities. Dysfunction of TRPV4 is linked to many severe diseases, including edema, pain, g
Externí odkaz:
https://doaj.org/article/2fc8028f0c104a9b845bdd1c9c58a9e8
Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice
Publikováno v:
Journal of Physiological Sciences, Vol 74, Iss 1, Pp 1-7 (2024)
Abstract There are a lot of temperature-sensitive proteins including transient receptor potential (TRP) channels. Some TRP channels are temperature receptors having specific activation temperatures in vitro that are within the physiological temperatu
Externí odkaz:
https://doaj.org/article/b0bea484373e4a43b4a0cea6a363acef
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Animals must sense and acclimatize to environmental temperatures for survival, yet their thermosensing mechanisms other than transient receptor potential (TRP) channels remain poorly understood. We identify a trimeric G protein-coupled recep
Externí odkaz:
https://doaj.org/article/bd908bf5ad7945a0bc9364b20fcf2161
Autor:
Jing Lei, Reiko U. Yoshimoto, Takeshi Matsui, Masayuki Amagai, Mizuho A. Kido, Makoto Tominaga
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract TRPV3, a non-selective cation transient receptor potential (TRP) ion channel, is activated by warm temperatures. It is predominantly expressed in skin keratinocytes, and participates in various somatic processes. Previous studies have report
Externí odkaz:
https://doaj.org/article/fbe83546e21e48d39d7718cc64743ace
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Transient receptor potential (TRP) channels are primary sensory molecules in animals and are involved in detecting a diverse range of physical and chemical cues in the environments. Considering the crucial role of TRPA1 channels in nocifensive behavi
Externí odkaz:
https://doaj.org/article/aac54ec129e94356833c377c57a0ac2a
Autor:
Takahiro Shimizu, Takuto Fujii, Keisuke Hanita, Ryo Shinozaki, Yusaku Takamura, Yoshiro Suzuki, Teppei Kageyama, Mizuki Kato, Hisao Nishijo, Makoto Tominaga, Hideki Sakai
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Bitterness is an important physiological function in the defense responses to avoid toxic foods. The taste receptor 2 family is well known to mediate bitter taste perception in Type II taste cells. Here, we report that the polycystic kidney
Externí odkaz:
https://doaj.org/article/e575a1d34a374d66b57ab711868c8be8
Autor:
Yu Yamanoi, Jing Lei, Yasunori Takayama, Shigekuni Hosogi, Yoshinori Marunaka, Makoto Tominaga
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
The chloride channel anoctamin1, upon activation by calcium influx through transient receptor potential vanilloid 3, mediates chloride influx and enhances wound healing in keratinocytes.
Externí odkaz:
https://doaj.org/article/f1639e62bb2745bcba495891d1d7cd87