Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Makoto Taiji"'
Autor:
Keigo Nishida, Makoto Taiji
Publikováno v:
IEEE Access, Vol 10, Pp 92959-92970 (2022)
Overfitting of neural networks to training data is one of the most significant problems in machine learning. Bayesian neural networks (BNNs) are known to be robust against overfitting owing to their ability to model parameter uncertainty. Bayes by Ba
Externí odkaz:
https://doaj.org/article/b5af2bf7c60747b2823443506a48088f
Publikováno v:
ACS Omega, Vol 6, Iss 27, Pp 17609-17620 (2021)
Externí odkaz:
https://doaj.org/article/7297c35f1edc4b0897e8fa28dff182d4
Publikováno v:
Biophysics and Physicobiology, Vol 17 (2020)
Following the discovery of cryptochrome-DASH (CRYD) as a new type of blue-light receptor cryptochrome, theoretical and experimental findings on CRYD have been reported. Early studies identified CRYD as highly homologous to the DNA repair enzyme photo
Externí odkaz:
https://doaj.org/article/86be6f80f6bd48ad9bd86bd78061c963
Publikováno v:
ACS Omega, Vol 3, Iss 4, Pp 4475-4485 (2018)
Externí odkaz:
https://doaj.org/article/06e5c5c2be9243a295f5c8996109ab80
Autor:
Noriaki Okimoto, Noriyuki Futatsugi, Hideyoshi Fuji, Atsushi Suenaga, Gentaro Morimoto, Ryoko Yanai, Yousuke Ohno, Tetsu Narumi, Makoto Taiji
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 10, p e1000528 (2009)
Virtual compound screening using molecular docking is widely used in the discovery of new lead compounds for drug design. However, this method is not completely reliable and therefore unsatisfactory. In this study, we used massive molecular dynamics
Externí odkaz:
https://doaj.org/article/ef230170b12d4529906bf1f6807f8913
Autor:
Alice T. Shaw, Jeffrey A. Engelman, Naoya Fujita, Yasushi Okuno, Makoto Taiji, Kengo Takeuchi, A. John Iafrate, Justin F. Gainor, Tahsin M. Khan, Elizabeth L. Lockerman, Sumie Koike, Luc Friboulet, Ryohei Katayama
Purpose: The first-generation ALK tyrosine kinase inhibitor (TKI) crizotinib is a standard therapy for patients with ALK-rearranged non–small cell lung cancer (NSCLC). Several next-generation ALK-TKIs have entered the clinic and have shown promisin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e9f418f575410780285c445e443751
https://doi.org/10.1158/1078-0432.c.6523703.v1
https://doi.org/10.1158/1078-0432.c.6523703.v1
Autor:
Alice T. Shaw, Jeffrey A. Engelman, Naoya Fujita, Yasushi Okuno, Makoto Taiji, Kengo Takeuchi, A. John Iafrate, Justin F. Gainor, Tahsin M. Khan, Elizabeth L. Lockerman, Sumie Koike, Luc Friboulet, Ryohei Katayama
Supplementary Figures S1-S7. Figure S1 contains the cell survival data of H3122 cells to multiple ALK-TKIs. Figure S2 contains the comparison of experimental IC50 values and calculated free energy values corresponding to Fig 3C. Figure S3 contains th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613f28600527647891d2593ff8f1b029
https://doi.org/10.1158/1078-0432.22457810.v1
https://doi.org/10.1158/1078-0432.22457810.v1
Publikováno v:
ACS Omega, Vol 6, Iss 27, Pp 17609-17620 (2021)
ACS Omega
ACS Omega
The interactions between proteins and ligands are involved in various biological functions. While experimental structures provide key static structural information of ligand-unbound and ligand-bound proteins, dynamic information is often insufficient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245edb8a2dfdee5c4d58531e9df677fb
https://doaj.org/article/7297c35f1edc4b0897e8fa28dff182d4
https://doaj.org/article/7297c35f1edc4b0897e8fa28dff182d4
Publikováno v:
Seibutsu Butsuri. 62:116-118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df8141c83aeea74bc628a8b433f5c3b3
https://doi.org/10.2142/biophys.62.116
https://doi.org/10.2142/biophys.62.116
Publikováno v:
Phys Chem Chem Phys
Spatiotemporal regulation of viral capsid assembly ensures the selection of the viral genome for encapsidation. The porcine circovirus 2 is the smallest autonomously replicating pathogenic virus, yet how PCV2 capsid assembly is regulated to occur wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7216ba23510ea67d016b9a7294264b69
https://doi.org/10.1039/d1cp02874j
https://doi.org/10.1039/d1cp02874j