Výsledky vyhledávání - "Makoto TAMAKI"

Synthesis of Novel Fatty-Acyl Gratisin Derivatives

Autor: Kenta Fujinuma, Takuji Harada, Yoshiki Uchida, Makoto Tamaki, Masahiro Kimura, Kazumasa Takanashi, Mitsuno Shindo

Publikováno v: Chemical and Pharmaceutical Bulletin. 60:743-746

To find candidates with high antimicrobial and low hemolytic activities, many gratisin (GR) analogues have been designed and synthesized. In the present account, we synthesized novel derivatives of GR having both the polycationic and fatty acyl group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e4912a266d57c88dfbe243b56ad713
https://doi.org/10.1248/cpb.60.743

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Fatty acyl-gramicidin S derivatives with both high antibiotic activity and low hemolytic activity

Autor: Kenta Fujinuma, Mitsuno Shindo, Makoto Tamaki, Yoshiki Uchida, Takuji Harada, Masahiro Kimura, Kazumasa Takanashi

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:106-109

In the present study, novel eight GS derivatives having the octanoyl-(Lys)n- moieties, cyclo{-Val-Orn-Leu- d -Phe-Pro(4β-NH-X)-Val-Orn-Leu- d -Phe-Pro-} {X = −H (1), and -(Lys)n-CO(CH2)6CH3 n = 0 (2), 1 (3), 2 (4), and 3 (5)} and cyclo{-Val-Orn-Le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873eb0a270f4364f5002b0b0d53da757
https://doi.org/10.1016/j.bmcl.2011.11.062

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Polycationic Gramicidin S Analogues with Both High Antibiotic Activity and Very Low Hemolytic Activity

Autor: Masahiro Kimura, Kazumasa Takanashi, Yoshiki Uchida, Makoto Tamaki, Kenta Fujinuma, Takuji Harada, Mitsuno Shindo

Publikováno v: Chemical and Pharmaceutical Bulletin. 60:1134-1138

The substitution of each constituent amino acid residue of gramicidin S (GS), cyclo(-Val(1,1')-Orn(2,2')-Leu(3,3')-D-Phe(4,4')-Pro(5,5')-)(2) with Lys residue indicated that each side chain structure of the constituent amino acid residues affect larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90e8be30b042b3ce63e4e0446496d75
https://doi.org/10.1248/cpb.c12-00290

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Novel Cycloundecapeptides Related to Gramicidin S with Both High Antibiotic Activity and Low Hemolytic Activity

Autor: Takuji Harada, Yoshiki Uchida, Kenta Fujinuma, Mitsuno Shindo, Makoto Tamaki, Masahiro Kimura, Kazumasa Takanashi

Publikováno v: Chemical and Pharmaceutical Bulletin. 59:1481-1484

To find candidates with high antimicrobial and low hemolytic activities, many gramicidin S (GS) analogs of various ring sizes have been designed and synthesized. However, syntheses of antimicrobially active analogues of GS having a disordered symmetr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cc2cdb3fef48ff44d0f43b12ee2fe6
https://doi.org/10.1248/cpb.59.1481

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Properties of synthetic analogs of gramicidin S containing L-serine or L-glutamic acid residue in place of L-ornithine residue

Autor: Makoto Tamaki, Sadatoshi Akabori, Ichiro Muramatsu

Publikováno v: International Journal of Peptide and Protein Research. 47:369-375

In order to investigate the biological role of the δ-amino groups of the Orn residue in gramicidin S, the four analogs, [Ser2]-, [Ser2,2′]-, [Glu2]- and [Glu2,2′]-gramicidin S were synthesized by a solution method. Except for the last one, these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4261efd85641797d2f7c450c3bc9ea0
https://doi.org/10.1111/j.1399-3011.1996.tb01086.x

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Biomimetic formation of gramicidin S by dimerization–cyclization of pentapeptide precursor on solid support

Autor: Makoto Tamaki, Sho Kikuchi, Kenji Honda, Rie Ishii

Publikováno v: Tetrahedron Letters. 47:8475-8478

The biomimetic formation of gramicidin S, cyclo(- d -Phe-Pro-Val-Orn-Leu-)2, by the dimerization and cyclization of pentapeptide precursor without the protection of δ-amino group of the Orn residue was examined on a solid support. The cyclization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22674f8de283d5b7fc9cb91fabd66c6a
https://doi.org/10.1016/j.tetlet.2006.09.146

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