Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Makoto T. Kimura"'
Autor:
Carla Grandori, Masayoshi Soma, Narendra Kumar Verma, Tsugumichi Koshinaga, Jin Takeuchi, Rajeev Mishra, Hiroki Nagase, Xiaofei Wang, Jun Igarashi, Shota Uekusa, Norimichi Nemoto, Nobuko Koshikawa, Takeshi Kusafuka, Yujin Kobayashi, Christopher J. Kemp, Takayoshi Watanabe, Diptiman Choudhury, Noboru Fukuda, Miki Ohira, Maki Ikeda, Kyoko Fujiwara, Makoto T. Kimura, Hiroyuki Kawashima
Publikováno v:
Cancer Science
The MYC transcription factor plays a crucial role in the regulation of cell cycle progression, apoptosis, angiogenesis, and cellular transformation. Due to its oncogenic activities and overexpression in a majority of human cancers, it is an interesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5c7020f89f99c54135af9110fb6349
https://doi.org/10.1111/cas.12610
https://doi.org/10.1111/cas.12610
Autor:
Noboru Fukuda, Xiaofei Wang, Hiroki Nagase, Linghua Wang, Hiroyuki Matsuda, Jun Igarashi, Min Chen, Takayoshi Watanabe, Tohru Sakimoto, Mitsuru Sawa, Makoto T. Kimura
Publikováno v:
Molecular Therapy. 18:519-527
Corneal alkali burns are a serious clinical problem that often leads to permanent visual impairment. In this process, transforming growth factor (Tgf)-beta1 is upregulated and involved in the response to corneal injury and the process of corneal stro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3dcb8eb7d81eb41958d0ece0571e0a
https://doi.org/10.1038/mt.2009.263
https://doi.org/10.1038/mt.2009.263
Autor:
Ken-ichi Shinohara, Makoto T. Kimura, Akimichi Ohtsuki, Toshikazu Bando, Hiroki Nagase, Hiroshi Sugiyama, Tsukasa Suzuki, Maki Ikeda, Masafumi Minoshima
Publikováno v:
Tetrahedron Letters. 50:7288-7292
We have designed and synthesized new types of pyrrole (P)-imidazole (I) polyamide conjugates 1 and 2 possessing a suberoylanilide hydroxamic acid (SAHA) moiety that is a strong inhibitor of histone deacetylase (HDAC). SAHA conjugate 2 was designed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b46ca6988eb59441aeac4b5541fb9129
https://doi.org/10.1016/j.tetlet.2009.10.034
https://doi.org/10.1016/j.tetlet.2009.10.034
Autor:
Makoto T. Kimura, Norma J. Nowak, Takahiro Mori, Susumu Satomi, Jeffrey M. Conroy, Hiroki Nagase, Katsuyuki Tamai
Publikováno v:
Cancer Research. 65:3548-3554
STK15/Aurora-A is a serine/threonine kinase essential for chromosome segregation and cytokinesis, and is considered to be a cancer susceptibility gene in mice and humans. Two coding single nucleotide polymorphisms in Aurora-A, 91T>A [phenylalanine/is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde215455de3a08f8ec172e01eb9e202
https://doi.org/10.1158/0008-5472.can-04-2149
https://doi.org/10.1158/0008-5472.can-04-2149
Autor:
Fei Song, Joseph F. Smith, Makoto T. Kimura, Tomoki Matsuyama, Hiroki Nagase, Arlene D. Morrow, William A. Held
Publikováno v:
Proceedings of the National Academy of Sciences. 102:3336-3341
Early studies proposed that DNA methylation could have a role in regulating gene expression during development [Riggs, A.D. (1975) Cytogenet. Cell Genet. 14, 9–25]. However, some studies of DNA methylation in known tissue-specific genes during deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b03ab98e61796e3037a8b2b866619a5
https://doi.org/10.1073/pnas.0408436102
https://doi.org/10.1073/pnas.0408436102
Autor:
Richard A. DiCioccio, Honglin Song, Christy Waterfall, Makoto T. Kimura, Hiroki Nagase, Valerie McGuire, Estrid Hogdall, Mitul N. Shah, Robert N. Luben, Douglas F. Easton, Ian J. Jacobs, Bruce A.J. Ponder, Alice S. Whittemore, Simon A. Gayther, Paul D.P. Pharoah, Susan Kruger-Kjaer
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 13:1589-1594
STK15 is a putative oncogene that codes for a centrosome-associated, serine/threonine kinase, the normal function of which is to ensure accurate segregation of chromosomes during mitosis. Amplification of STK15 has been reported in ovarian tumors, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a74270b9b1fa3ee0badf765286e113
https://doi.org/10.1158/1055-9965.1589.13.10
https://doi.org/10.1158/1055-9965.1589.13.10
Autor:
Christine B. Ambrosone, Hiroki Nagase, Kathleen M. Egan, Linda Titus-Ernstoff, Makoto T. Kimura, Amy Trentham-Dietz, Polly A. Newcomb, John M. Hampton
Publikováno v:
Carcinogenesis. 25:2149-2153
STK15 is considered a potential cancer susceptibility gene owing to its functions in normal cell mitosis. Two common coding region polymorphisms in the gene (F31I and V57I) may affect ubiquitin-dependent degradation and thus the half-life of the enco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66738b9bfceb83bd5e92cf7c96cf2aa
https://doi.org/10.1093/carcin/bgh231
https://doi.org/10.1093/carcin/bgh231
Autor:
Masatoshi Makuuchi, Kyoko Fujiwara, Jun Igarashi, Makoto T. Kimura, Dongfeng Tan, Ai Min Hui, Masahiko Tsurumaru, Hiroki Nagase, Haruhiko Okada
Expression profiling analysis revealed ectopic high expression of mouse TFF3 in non-tumor liver tissues from the hepatocellular carcinoma (HCC) susceptible PWK/Rbrc strain. TFF3 is a member of the trefoil factor family peptides, which are small secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ab37e1e4b8fd26c4b69afc1b683d67
https://europepmc.org/articles/PMC2292801/
https://europepmc.org/articles/PMC2292801/
Autor:
Toshikazu Ebisuzaki, Tadao Asami, Tomoki Matsuyama, Hiroki Nagase, Tomoko Abe, Kuniaki Koike, Shigeo Yoshida, Takeshi Nakano, William A. Held, Makoto T. Kimura
Publikováno v:
Nucleic acids research. 31(15)
Understanding the role of ‘epigenetic’ changes such as DNA methylation and chromatin remodeling has now become critical in understanding many biological processes. In order to delineate the global methylation pattern in a given genomic DNA, compu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f2f75f93b97d2f62bf3a1894addd5c2
https://pubmed.ncbi.nlm.nih.gov/12888509
https://pubmed.ncbi.nlm.nih.gov/12888509
Autor:
Jun, Mukai, Shisako, Shoji, Makoto T, Kimura, Shuichi, Okubo, Hajime, Sano, Petro, Suvanto, Yin, Li, Shinji, Irie, Taka-Aki, Sato
Publikováno v:
The Journal of biological chemistry. 277(16)
Nerve growth factor (NGF) can induce apoptosis in neural cells via activation of the low affinity neurotrophin receptor p75NTR. NADE (p75NTR-associated cell death executor) is a p75NTR-associated protein that mediates apoptosis in response to NGF by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d71027ae1c096e97355d42dff30003f
https://pubmed.ncbi.nlm.nih.gov/11830582
https://pubmed.ncbi.nlm.nih.gov/11830582