Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Makoto Shiozaki"'
Autor:
Masayuki Kotoku, Makoto Shiozaki, Akihiro Nomura, Takayuki Yamaguchi, Scott Thacher, Haiyan Tao, Paul Crowe, Satoki Doi, Keishi Yamaguchi, Shintaro Hirashima, Katsuya Maeda, Masato Noguchi, Tsuyoshi Adachi, Yoshiaki Katsuda, Kazuyuki Hirata
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports
Scientific Reports
Retinoic acid-related orphan receptor gamma (RORγ) plays pivotal roles in autoimmune diseases by controlling the lineage of interleukin 17 (IL-17)-producing CD4+ T cells (Th17 cells). Structure-based drug design has proven fruitful in the developmen
Autor:
Yoshifumi Ueyama, Yutaka Ukaji, Keisuke Nozawa, Katsuya Maeda, Shohei Miwa, Tomohiro Ishikawa, Yuki Kitao, Tsuyoshi Adachi, Naoki Ogawa, Makoto Shiozaki, Yokota Masahiro, Yosuke Ogoshi, Seki Noriyoshi, Jun Nishihata, Akihiro Nomura
Publikováno v:
ACS Med Chem Lett
[Image: see text] Historically, modulation of transforming growth factor β (TGF-β) signaling has been deemed a rational strategy to treat many disorders, though few successful examples have been reported to date. This difficulty could be partially
Publikováno v:
Polymer International. 69
Autor:
Takuya Orita, Masafumi Inoue, Tomoya Miura, Yoshinori Hara, Makoto Shiozaki, Hiroshi Yamamoto, Shingo Obika, Hiroshi Yamanaka, Chika Oki, Yukari Kimoto, Yoshihiro Ogawa, Tsuyoshi Adachi, Atsuo Tanimoto, Akimi Hori, Satoru Noji, Hiromasa Hashimoto, Yasunori Hase, Tamotsu Negoro, Satoki Doi, Katsuya Maeda
Publikováno v:
Journal of medicinal chemistry. 63(13)
Dermatologic disorders such as atopic dermatitis arise from genetic and environmental causes and are complex and multifactorial in nature. Among possible risk factors, aberrant immunological reactions are one of the leading etiologies. Immunosuppress
Autor:
Akihiro Nomura, Kojo Arita, Paul D. Crowe, Kazuyuki Hirata, Makoto Shiozaki, Keisuke Ito, Naoki Miyagawa, Yoshiaki Katsuda, Kota Asahina, Hiromasa Hashimoto, Yoshihiro Suwa, Masayuki Kotoku, Haiyan Tao, Yasunori Hase, Yokota Masahiro, Seki Noriyoshi, Fujioka Shingo, Satoki Doi, Tsuyoshi Adachi, Masato Noguchi, Scott M. Thacher, Takayoshi Suzuki, Taku Ikenogami, Takaki Maeba
Publikováno v:
Journal of medicinal chemistry. 62(5)
Starting from a previously reported RORγ inhibitor (1), successive efforts to improve in vivo potency were continued. Introduction of metabolically beneficial motifs in conjunction with scaffold hopping was examined, resulting in discovery of the se
Autor:
Keisuke Nozawa, Chika Oki, Akira Matsuo, Satoru Noji, Makoto Shiozaki, Yukari Kimoto, Yoshihiro Ogawa, Mutsuyoshi Matsushita, Yuichi Shinozaki, Atsuo Tanimoto, Wataru Amano
Publikováno v:
Inflammation Research
Objective To evaluate the pharmacological properties of JTE-052, a novel Janus kinase (JAK) inhibitor. Methods The JAK inhibitory activity of JTE-052 was evaluated using recombinant human enzymes. The inhibitory effects on cytokine signaling pathways
Autor:
Yoshiaki Katsuda, Erin Bradley, Masato Noguchi, Masafumi Kamada, Kazuyuki Hirata, Haiyan Tao, Xioalin Li, Paul Crowe, Bruno Tse, Masayuki Kotoku, Akihiro Nomura, Ken Murase, Tsuyoshi Adachi, Ruo Steensma, Takayuki Yamaguchi, Makoto Shiozaki, Keishi Yamaguchi, Morgan Fenn, Scott Thacher, Satoki Doi, Shintaro Hirashima, Robert Babine
Publikováno v:
Genes to cells : devoted to molecularcellular mechanisms. 22(6)
Retinoid-related orphan receptor gamma (RORγ) directly controls the differentiation of Th17 cell and the production of interleukin-17, which plays an integral role in autoimmune diseases. To obtain insight into RORγ, we have determined the first cr
Autor:
Ryohei Yokoyama, Tomohisa Hatta, Ryusuke Nakagawa, Hayakawa Nobuhiko, Masataka Shoji, Makoto Shiozaki, Manami Shuto, Yoichiro Shima, Kanna Kuribayashi, Hiroyuki Eda, Misato Noguchi, Yukie Seki, Manabu Suzuki, Agung Eviryanti, Shun-ichiro Iemura, Ayatoshi Andou, Hikaru Nishio, Sen Takeshita, Takashi Yamamoto, Masatsugu Noguchi, Kuniya Sakurai, Tohru Natsume, Shunsuke Kageyama, Itsuya Tanabe
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:3021-3029
Interleukin-12 (IL-12) and IL-23 are proinflammatory cytokines and therapeutic targets for inflammatory and autoimmune diseases, including inflammatory bowel diseases, psoriasis, rheumatoid arthritis, and multiple sclerosis. We describe the discovery
Publikováno v:
半田山地理考古. 2:67-77
Publikováno v:
Journal of Bone and Mineral Metabolism. 32:653-659
Clinical evidence suggests that, compared with alendronate, risedronate reduces fracture risk faster and more potently, with less bone mass gain. We tested the hypothesis that risedronate improves bone quality faster than alendronate using calcium-de