Zobrazeno 1 - 10
of 486
pro vyhledávání: '"Makoto Sawada"'
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 7, Iss , Pp 100196- (2024)
Nucleolar stress induced by stressors like hypoxia, UV irradiation, and heat shock downregulates ribosomal RNA transcription, thereby impairing protein synthesis capacity and potentially contributing to cell senescence and various human diseases such
Externí odkaz:
https://doaj.org/article/cf8c2920bf1548b3b53f499acde8ca82
Autor:
Vincenzo Sapienza, Marco Miceli, Aya Bamba, Salvatore Orlando, Shiu-Hang Lee, Shigehiro Nagataki, Masaomi Ono, Satoru Katsuda, Koji Mori, Makoto Sawada, Yukikatsu Terada, Roberta Giuffrida, Fabrizio Bocchino
Publikováno v:
The Astrophysical Journal Letters, Vol 961, Iss 1, p L9 (2024)
Supernova (SN) 1987A is one of the best candidates to exploit the capabilities of the freshly launched XRISM satellite. This celestial object offers the unique opportunity to study the evolution of an SN into a young supernova remnant. To date, the X
Externí odkaz:
https://doaj.org/article/45ff88831b6044cc90da5e0e81ab408e
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12131 (2023)
Extracellular vesicles, such as microvesicles (LEV) and exosomes (SEV), play an important role in intercellular signaling by encapsulating functional molecules and delivering them to specific cells. Recent studies showed that signal peptides (SPs), w
Externí odkaz:
https://doaj.org/article/6b10206827ee46cdb47923b7e034723c
Autor:
Masahide Inoue, Koji Sakamoto, Atsushi Suzuki, Shinya Nakai, Akira Ando, Yukihiko Shiraki, Yoshio Nakahara, Mika Omura, Atsushi Enomoto, Ikuhiko Nakase, Makoto Sawada, Naozumi Hashimoto
Publikováno v:
Particle and Fibre Toxicology, Vol 18, Iss 1, Pp 1-20 (2021)
Abstract Background As the application of silica nanomaterials continues to expand, increasing chances of its exposure to the human body and potential harm are anticipated. Although the toxicity of silica nanomaterials is assumed to be affected by th
Externí odkaz:
https://doaj.org/article/bbf4ce803e51435c8ccdaee38db4d5ab
Autor:
Kenji Ono, Mikio Niwa, Hiromi Suzuki, Nahoko Bailey Kobayashi, Tetsuhiko Yoshida, Makoto Sawada
Publikováno v:
Cells, Vol 12, Iss 1, p 158 (2022)
Signal peptides (SPs) and their fragments play important roles as biomarkers and substances with physiological functions in extracellular fluid. We previously reported that SP fragments were released into extracellular fluid via exosomes and bound to
Externí odkaz:
https://doaj.org/article/7c8e9ddb7d49418290925cc0aa83af71
Autor:
Naoki Yoshioka, Miyako Tanaka, Kozue Ochi, Akiko Watanabe, Kenji Ono, Makoto Sawada, Tomoo Ogi, Michiko Itoh, Ayaka Ito, Yukihiro Shiraki, Atsushi Enomoto, Masatoshi Ishigami, Mitsuhiro Fujishiro, Yoshihiro Ogawa, Takayoshi Suganami
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 140, Iss , Pp 111738- (2021)
Background: Diabetes and obesity contribute to the pathogenesis of nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). However, how diabetes and obesity accelerate liver tumorigenesis remains to be fully understood. Moreover, to v
Externí odkaz:
https://doaj.org/article/02d4b3437efc4482872c321aa51cf391
Autor:
Kenji Ono, Mikio Niwa, Hiromi Suzuki, Nahoko Bailey Kobayashi, Tetsuhiko Yoshida, Makoto Sawada
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3137 (2022)
Signal peptides (SPs) not only mediate targeting to the endoplasmic reticulum (ER) but also play important roles as biomarkers and substances with physiological activity in extracellular fluids including blood. SPs are thought to be degraded intracel
Externí odkaz:
https://doaj.org/article/d8988fff826845c09ed6cd026f042284
Autor:
Hsiaoyun Lin, Rieko Muramatsu, Noriko Maedera, Hiroto Tsunematsu, Machika Hamaguchi, Yoshihisa Koyama, Mariko Kuroda, Kenji Ono, Makoto Sawada, Toshihide Yamashita
Publikováno v:
EBioMedicine, Vol 27, Iss C, Pp 71-85 (2018)
Angiogenesis, a prominent feature of pathology, is known to be guided by factors secreted by living cells around a lesion. Although many cells are disrupted in a response to injury, the relevance of degenerating cells in pathological angiogenesis is
Externí odkaz:
https://doaj.org/article/3b497d3de9d349e3acb11f39cd334351
Autor:
Makoto Sawada, Yohei Okada, Noriyuki Kamata, Masaru Narita, Yasutaka Nikaido, Satoshi Yamamoto, Shu Morioka, Nobutaka Hattori, Hideyuki Urakami, Tsubasa Kawasaki, Koji Shomoto, Junji Nakamura, Hiroyuki Ohtsuka, Masayuki Okamoto
Publikováno v:
Journal of Parkinson's Disease
Background: Long-term physiotherapy is acknowledged to be crucial to manage motor symptoms for Parkinson’s disease (PD) patients, but its effectiveness is not well understood. Objective: This systematic review and meta-analysis aimed to assess the
Autor:
Misaki Mizumoto, Masahiro Tsujimoto, Renata Cumbee, Megan E. Eckart, Yoshitaka Ishisaki, Caroline A. Kilbourne, Edmund Hodges-Kluck, Maurice A. Leutenegger, Frederick S. Porter, Makoto Sawada, Yoh Takei, Yuusuke Uchida, Shinya Yamada
Publikováno v:
Space Telescopes and Instrumentation 2022: Ultraviolet to Gamma Ray.