Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Makoto Sahara"'
Autor:
Nevin Witman, Chikai Zhou, Timm Häneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmér, Niels Grote Beverborg, Miia L. Lehtinen, Kenneth R. Chien, Makoto Sahara
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Cardiogenic growth factors play important roles in heart development. Placental growth factor (PLGF) has previously been reported to have angiogenic effects; however, its potential role in cardiogenesis has not yet been determined. We analyz
Externí odkaz:
https://doaj.org/article/e6da8a6cf91241599f130c97c715953e
Autor:
Nevin Witman, Chikai Zhou, Timm Häneke, Yao Xiao, Xiaoting Huang, Eduarde Rohner, Jesper Sohlmér, Niels Grote Beverborg, Miia L. Lehtinen, Kenneth R. Chien, Makoto Sahara
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f7261ffe7a7a4b8491b2ec59ef14a97b
Autor:
Eduarde Rohner, Nevin Witman, Jesper Sohlmer, Erwin De Genst, William E. Louch, Makoto Sahara, Kenneth R. Chien
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-12 (2021)
Abstract Background The human L39X phospholamban (PLN) cardiomyopathic mutant has previously been reported as a null mutation but the detailed molecular pathways that lead to the complete lack of detectable protein remain to be clarified. Previous st
Externí odkaz:
https://doaj.org/article/01255acd28e041f6acfa35e58ea55910
Autor:
Makoto Sahara
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6244 (2023)
Cardiac organoids are in vitro self-organizing and three-dimensional structures composed of multiple cardiac cells (i.e., cardiomyocytes, endothelial cells, cardiac fibroblasts, etc.) with or without biological scaffolds. Since cardiac organoids reca
Externí odkaz:
https://doaj.org/article/b24a7e34acb248a3a4425b2254a4f206
Autor:
Clara Sze Man Tang, Mimmi Mononen, Wai-Yee Lam, Sheng Chih Jin, Xuehan Zhuang, Maria-Mercè Garcia-Barcelo, Qiongfen Lin, Yujia Yang, Makoto Sahara, Elif Eroglu, Kenneth R. Chien, Haifa Hong, Paul Kwong Hang Tam, Peter J. Gruber
Publikováno v:
JCI Insight, Vol 7, Iss 2 (2022)
Tetralogy of Fallot (TOF) is the most common cyanotic heart defect, yet the underlying genetic mechanisms remain poorly understood. Here, we performed whole-genome sequencing analysis on 146 nonsyndromic TOF parent-offspring trios of Chinese ethnicit
Externí odkaz:
https://doaj.org/article/d91ab361a59a4841b58371be7eae5b00
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100339- (2021)
Summary: The combination of population and single-cell RNA sequencing analysis using human embryonic stem cell (hESC) differentiation and developmental tissues is a powerful approach to elucidate an organ-specific cellular and molecular atlas in huma
Externí odkaz:
https://doaj.org/article/ad23ae2849d842188a1fa8bdd1c8e415
Autor:
Timm Häneke, Makoto Sahara
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3482 (2022)
The human heart has the least regenerative capabilities among tissues and organs, and heart disease continues to be a leading cause of mortality in the industrialized world with insufficient therapeutic options and poor prognosis. Therefore, developi
Externí odkaz:
https://doaj.org/article/0022de66671b48a39931da8cef43bfb8
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp n/a-n/a (2019)
The advent of pluripotent stem cell biology and facile genetic manipulation via CRISPR technology has ushered in a new era of human disease models for drug discovery and development. While these precision “super models” hold great promise for tai
Externí odkaz:
https://doaj.org/article/9f71bdcfe90e47b09a2642ae3e47abae
Autor:
Nevin Witman, Makoto Sahara
Publikováno v:
Stem Cells International, Vol 2018 (2018)
Major cardiovascular events including myocardial infarction (MI) continue to dominate morbidity rates in the developed world. Although multiple device therapies and various pharmacological agents have been shown to improve patient care and reduce mor
Externí odkaz:
https://doaj.org/article/70444bc41f88443f9838c90194ce987d
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33367 (2012)
BACKGROUND: An antianginal K(ATP) channel opener nicorandil has various beneficial effects on cardiovascular systems; however, its effects on pulmonary vasculature under pulmonary arterial hypertension (PAH) have not yet been elucidated. Therefore, w
Externí odkaz:
https://doaj.org/article/26edf40ef9694aa69470cbede5c2e99e