Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Makoto Saegusa"'
Autor:
Yu Ishibashi, Takashi Itoh, Yasuko Oguri, Miki Hashimura, Ako Yokoi, Toshihide Matsumoto, Yohei Harada, Naomi Fukagawa, Misato Hayashi, Mototsugu Ono, Chika Kusano, Makoto Saegusa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Here, we focused on the role of Nucleobindin 2 (NUCB2), a multifunctional protein, in gastric carcinoma (GC) progression. NUCB2 expression was investigated in 150 GC cases (20 non-invasive (pT1) and 130 invasive (pT2/pT3/pT4) tumors) by immu
Externí odkaz:
https://doaj.org/article/0795f4bbc87e48f1ab13595229a7984a
Autor:
Mayu Nakagawa, Toshihide Matsumoto, Ako Yokoi, Miki Hashimura, Yasuko Oguri, Ryo Konno, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Yohei Harada, Naomi Fukagawa, Yoshio Kodera, Makoto Saegusa
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2168-2182 (2023)
Ezrin‐radixin‐moesin‐binding phosphoprotein 50 (EBP50) is a scaffold protein that is required for epithelial polarity. Knockout (KO) of membranous EBP50 (Me‐EBP50) in ovarian clear cell carcinoma (OCCC) cells induced an epithelial–mesenchym
Externí odkaz:
https://doaj.org/article/7e7954c3079048c69b5d73cd08649fda
Autor:
Ako Yokoi, Yusaku Nakamura, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa, Makoto Saegusa
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-13 (2023)
Abstract Background Although anaplastic lymphoma kinase (ALK) is overexpressed in several primary solid tumor types, its role in endometrial carcinoma (Em Ca) remains unclear. Methods We evaluated expression of ALK and its related molecules in clinic
Externí odkaz:
https://doaj.org/article/86ccc7d071264af4817b4c0445d9db26
Autor:
Hiroyuki Takahashi, Sabine Kajita, Hiroshi Katoh, Toshihide Matsumoto, Akemi Inoue, Takafumi Sangai, Makoto Saegusa
Publikováno v:
Heliyon, Vol 10, Iss 4, Pp e25843- (2024)
We report a case of immunoglobulin (ig)-g4-related thyroiditis associated with graves’ disease. a 45-year-old man was diagnosed with graves’ disease due to asymptomatic enlarged thyroid gland and high serum levels of thyrotropin receptor antibodi
Externí odkaz:
https://doaj.org/article/deefc1f055a747da91625193bf2f33fd
Autor:
Ako Yokoi, Marina Minami, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Yoshinori Hasegawa, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa, Makoto Saegusa
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-14 (2022)
Abstract Background Although a lack of functional PTEN contributes to tumorigenesis in a wide spectrum of human malignancies, little is known about the functional role of its overexpression in the tumors. The current study focused on PTEN overexpress
Externí odkaz:
https://doaj.org/article/5c33529686e6401cab411ca7dce67c4f
Autor:
Hiroyuki Takahashi, Hirono Watanabe, Miki Hashimura, Toshihide Matsumoto, Ako Yokoi, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Makoto Saegusa
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 5, Pp 458-469 (2022)
Abstract Programmed cell death‐1 (PD‐1) and its ligand (PD‐L1) are significant mediators of immune suppression in the tumor microenvironment. We focused on the immunological impact of PD‐1/PD‐L1 signaling during tumor progression in colorec
Externí odkaz:
https://doaj.org/article/2d58648ee97e4fcda8c8e86b6ede8788
Autor:
Madoca Inukai, Ako Yokoi, Yuuki Ishizuka, Miki Hashimura, Toshihide Matsumoto, Yasuko Oguri, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Toshihiro Kumabe, Makoto Saegusa
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Glioblastoma (GBM) is the most aggressive form of brain tumor and has vascular-rich features. The S100A4/non-muscle myosin IIA (NMIIA) axis contributes to aggressive phenotypes in a variety of human malignancies, but little is kno
Externí odkaz:
https://doaj.org/article/118c5815b145431691a61bb8411d35b5
Autor:
Mayu Nakagawa, Shyoma Higuchi, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Ako Yokoi, Yu Ishibashi, Takashi Ito, Makoto Saegusa
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background S100A1 expression is deregulated in a variety of human malignancies, but its role in normal and malignant endometrial cells is unclear. Methods We used endometrial carcinoma (Em Ca) cell lines to evaluate the physical and function
Externí odkaz:
https://doaj.org/article/4ef23dec703d416db66079f8d1d4c539
Autor:
Seiichiro Kusuhara, Satoshi Igawa, Masaaki Ichinoe, Ryo Nagashio, Yuki Kuchitsu, Yasuhiro Hiyoshi, Kazu Shiomi, Yoshiki Murakumo, Makoto Saegusa, Yukitoshi Satoh, Yuichi Sato, Katsuhiko Naoki
Publikováno v:
Thoracic Cancer, Vol 12, Iss 10, Pp 1570-1578 (2021)
Abstract Background Galectin‐3 (GAL3), a protein encoded by the LGALS3 gene, plays diverse roles in cancer initiation, progression, and drug resistance. Accordingly, high GAL3 expression in tumor cells is associated with poor prognosis in non‐sma
Externí odkaz:
https://doaj.org/article/4cda37681aad4fd8bc72fddb2db289c0
Autor:
Ako Yokoi, Toshihide Matsumoto, Yasuko Oguri, Yoshinori Hasegawa, Masataka Tochimoto, Mayu Nakagawa, Makoto Saegusa
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-15 (2020)
Abstract Background We previously demonstrated that ovarian high grade serous carcinomas (OHGSeCa) and ovarian clear cell carcinomas (OCCCa) with an HNF-1β+/p53+/ARID1A+ immunophenotype were associated with the worst unfavorable prognosis. To clarif
Externí odkaz:
https://doaj.org/article/5564ccbe9d5543d2bd136f278e8464e8