Zobrazeno 1 - 10
of 175
pro vyhledávání: '"Makoto Otsu"'
Autor:
Huan-Ting Lin, Masatoshi Takagi, Kenji Kubara, Kazuto Yamazaki, Fumiko Michikawa, Takashi Okumura, Takuya Naruto, Tomohiro Morio, Koji Miyazaki, Hideki Taniguchi, Makoto Otsu
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background Although oncogenic RAS mutants are thought to exert mutagenic effects upon blood cells, it remains uncertain how a single oncogenic RAS impacts non-transformed multipotent hematopoietic stem or progenitor cells (HPCs). Such potent
Externí odkaz:
https://doaj.org/article/41b677ec4b61423aabb1d9bf49e2ae0f
Autor:
Toru Uchiyama, Sirirat Takahashi, Kazuhiko Nakabayashi, Kohji Okamura, Kaori Edasawa, Masafumi Yamada, Nobuyuki Watanabe, Emi Mochizuki, Toru Yasuda, Akane Miura, Motohiro Kato, Daisuke Tomizawa, Makoto Otsu, Tadashi Ariga, Masafumi Onodera
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 424-433 (2021)
Two patients with adenosine deaminase (ADA)-deficient severe combined immunodeficiency (ADA-SCID) received stem cell-based gene therapy (SCGT) using GCsapM-ADA retroviral vectors without preconditioning in 2003 and 2004. The first patient (Pt1) was t
Externí odkaz:
https://doaj.org/article/6fb1a6f160bc4bf28be4eb6c6b2e29cc
Autor:
Manabu Kawata, Daisuke Mori, Kosuke Kanke, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Fumiko Yano, Hideki Masaki, Makoto Otsu, Hiromitsu Nakauchi, Sakae Tanaka, Taku Saito
Publikováno v:
Stem Cell Reports, Vol 13, Iss 3, Pp 530-544 (2019)
Summary: A simple induction protocol to differentiate chondrocytes from pluripotent stem cells (PSCs) using small-molecule compounds is beneficial for cartilage regenerative medicine and mechanistic studies of chondrogenesis. Here, we demonstrate tha
Externí odkaz:
https://doaj.org/article/2dc64c25609b46b1a78010c2c0ad39fe
Autor:
Takashi Okumura, Yumi Horie, Chen-Yi Lai, Huan-Ting Lin, Hirofumi Shoda, Bunki Natsumoto, Keishi Fujio, Eri Kumaki, Tsubasa Okano, Shintaro Ono, Kay Tanita, Tomohiro Morio, Hirokazu Kanegane, Hisanori Hasegawa, Fumitaka Mizoguchi, Kimito Kawahata, Hitoshi Kohsaka, Hiroshi Moritake, Hiroyuki Nunoi, Hironori Waki, Shin-ichi Tamaru, Takayoshi Sasako, Toshimasa Yamauchi, Takashi Kadowaki, Hiroyuki Tanaka, Sachiko Kitanaka, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Makoto Otsu
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2019)
Abstract Background Disease modeling with patient-derived induced pluripotent stem cells (iPSCs) is a powerful tool for elucidating the mechanisms underlying disease pathogenesis and developing safe and effective treatments. Patient peripheral blood
Externí odkaz:
https://doaj.org/article/e9a9e96b9aae4d00878ec8608b4ef191
Autor:
Kazuki Taoka, Shunya Arai, Keisuke Kataoka, Masataka Hosoi, Masashi Miyauchi, Sho Yamazaki, Akira Honda, Wei Aixinjueluo, Takashi Kobayashi, Keiki Kumano, Akihide Yoshimi, Makoto Otsu, Akira Niwa, Tatsutoshi Nakahata, Hiromitsu Nakauchi, Mineo Kurokawa
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Abstract Chronic myelomonocytic leukemia (CMML) is an entity of myelodysplastic syndrome/myeloproliferative neoplasm. Although CMML can be cured with allogeneic stem cell transplantation, its prognosis is generally very poor due to the limited effica
Externí odkaz:
https://doaj.org/article/ca6c14c5e42546afa52dabe821a5a19d
Autor:
Kenji Kubara, Kazuto Yamazaki, Yasuharu Ishihara, Takuya Naruto, Huan-Ting Lin, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Masashi Ito, Kappei Tsukahara, Tomohiro Morio, Masatoshi Takagi, Makoto Otsu
Publikováno v:
Stem Cell Reports, Vol 11, Iss 2, Pp 380-394 (2018)
Summary: Oncogenic KRAS mutations in hematopoietic stem cells cause RAS-associated autoimmune lymphoproliferative syndrome-like disease (RALD). KRAS plays essential roles in stemness maintenance in some types of stem cells. However, its roles in plur
Externí odkaz:
https://doaj.org/article/bec0e0806fec42e48f4d3ad662e1e2de
Autor:
Yu Takahashi, Shintaro Sato, Yosuke Kurashima, Tomohisa Yamamoto, Shiho Kurokawa, Yoshikazu Yuki, Naoki Takemura, Satoshi Uematsu, Chen-Yi Lai, Makoto Otsu, Hiroshi Matsuno, Hideki Osawa, Tsunekazu Mizushima, Junichi Nishimura, Mikio Hayashi, Takayuki Yamaguchi, Hiroshi Kiyono
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 314-328 (2018)
Summary: Gut epithelial organoids are routinely used to investigate intestinal biology; however, current culture methods are not amenable to genetic manipulation, and it is difficult to generate sufficient numbers for high-throughput studies. Here, w
Externí odkaz:
https://doaj.org/article/c4006f10f2d34228a3837a3832bd0c9b
Autor:
Yu Takahashi, Shintaro Sato, Yosuke Kurashima, Chen-Yi Lai, Makoto Otsu, Mikio Hayashi, Takayuki Yamaguchi, Hiroshi Kiyono
Publikováno v:
EBioMedicine, Vol 23, Iss C, Pp 34-45 (2017)
Visceral fat accumulation as observed in Crohn's disease and obesity is linked to chronic gut inflammation, suggesting that accumulation of gut adipocytes can trigger local inflammatory signaling. However, direct interactions between intestinal epith
Externí odkaz:
https://doaj.org/article/2937843aee024f808b3fc7ba601ce62e
Autor:
Mana Iizuka-Koga, Hiromitsu Asashima, Miki Ando, Chen-Yi Lai, Shinji Mochizuki, Mahito Nakanishi, Toshinobu Nishimura, Hiroto Tsuboi, Tomoya Hirota, Hiroyuki Takahashi, Isao Matsumoto, Makoto Otsu, Takayuki Sumida
Publikováno v:
Stem Cell Reports, Vol 8, Iss 5, Pp 1155-1163 (2017)
Although it is important to clarify the pathogenic functions of T cells in human samples, their examination is often limited due to difficulty in obtaining sufficient numbers of dendritic cells (DCs), used as antigen-presenting cells, especially in a
Externí odkaz:
https://doaj.org/article/12f69b208b4d43f28e2e556044abcc1e
Autor:
Aki Ieyasu, Reiko Ishida, Takaharu Kimura, Maiko Morita, Adam C. Wilkinson, Kazuhiro Sudo, Toshinobu Nishimura, Jun Ohehara, Yoko Tajima, Chen-Yi Lai, Makoto Otsu, Yukio Nakamura, Hideo Ema, Hiromitsu Nakauchi, Satoshi Yamazaki
Publikováno v:
Stem Cell Reports, Vol 8, Iss 3, Pp 500-508 (2017)
Hematopoietic stem cells (HSCs) are considered one of the most promising therapeutic targets for the treatment of various blood disorders. However, due to difficulties in establishing stable maintenance and expansion of HSCs in vitro, their insuffici
Externí odkaz:
https://doaj.org/article/47fe572a6dc64eb6ae4582546be94214