Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Makoto Osabe"'
Publikováno v:
Molecular Medicine Reports. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61a9969693b7b7bb0a579fa1a0fc74b7
https://doi.org/10.3892/mmr.2023.12938
https://doi.org/10.3892/mmr.2023.12938
Autor:
Kunihito Asano, Masahiro Tohkin, Keiko Maekawa, Naoki Miyata, Yoshiro Saito, Satomi Yagi, Shinsuke Iida, Makoto Osabe
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:187-190
Recently, genomic biomarkers have been widely used clinically for prediction of the efficacy and safety of pharmacotherapy and diagnosis and prognosis of pathological conditions. Therefore, genomic biomarkers are anticipated to accelerate not only pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ee096fdd6e7d1b1d1b89ff5b14cf96
https://doi.org/10.1016/j.dmpk.2020.01.003
https://doi.org/10.1016/j.dmpk.2020.01.003
Publikováno v:
Chem-Bio Informatics Journal. 16:1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c9fae8f4d9d11075cd53f6a613536c
https://doi.org/10.1273/cbij.16.1
https://doi.org/10.1273/cbij.16.1
Publikováno v:
Molecular and Cellular Biology. 37
The nuclear receptor CAR (NR1I3) regulates hepatic drug and energy metabolism as well as cell fate. Its activation can be a critical factor in drug-induced toxicity and the development of diseases, including diabetes and tumors. CAR inactivates its c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff01b846662a5311b42ed96b46c0af2
https://doi.org/10.1128/mcb.00649-16
https://doi.org/10.1128/mcb.00649-16
The effect of lapatinib on lymphocyte activation and transcription factors in T cell differentiation
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8692a6d31155dc80b818dd2588409a5a
https://doi.org/10.1254/jpssuppl.wcp2018.0_po3-4-6
https://doi.org/10.1254/jpssuppl.wcp2018.0_po3-4-6
Publikováno v:
Drug Metab. Dispos.. 38:177-186
Hepatocyte growth factor (HGF), an antimitogenic factor for HepG2 cells, increased mRNA and protein levels of UGT1A1 and CYP2B6, as well as the endogenous cyclin-dependent kinase (CDK) inhibitors p16, p21, and p27 in HepG2 cells but not in HuH6, Caco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2da003b182403f116653ac8acfc2d48
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100614881
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100614881
Autor:
Masao Miwa, Masatoshi Kurosawa, Yasuhiro Yamazaki, Junko Sugatani, Akiko Takemura, Akira Ikari, Makoto Osabe
Publikováno v:
FEBS Letters. 583:885-889
Constitutive androstane receptor (CAR) is a transcription factor regulating the expression of several genes related to drug metabolism. CAR expression was elevated in human HepG2 and SW480 cells by serum starvation. From reporter gene assays, mutagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92e8e31c3a84b2d2fdc351f4ebfca6b
https://doi.org/10.1016/j.febslet.2009.01.051
https://doi.org/10.1016/j.febslet.2009.01.051
Autor:
Akiko Takemura, Masahiko Negishi, Akira Ikari, Naomi Kitamura, Junko Sugatani, Makoto Osabe, Masao Miwa, Yasuhiro Yamazaki
Publikováno v:
Biochemical and Biophysical Research Communications. 369:1027-1033
Constitutive androstane receptor (CAR) is a transcription factor to regulate the expression of several genes related to drug-metabolism. Here, we demonstrate that CAR protein accumulates during G1 in human SW480 and HepG2 cells. After the G1/S phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940533e940ee192fd6b6afc5b222f8c7
https://doi.org/10.1016/j.bbrc.2008.02.140
https://doi.org/10.1016/j.bbrc.2008.02.140
Autor:
Makoto Osabe, Hitoshi Takagi, Masao Miwa, Akira Ikari, Satoru Kakizaki, Masatomo Mori, Junko Sugatani, Kasumi Yamakawa, Kousuke Mizushima
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 377:597-605
Human UDP-glucuronosyltransferase (UGT)1A1 is a critical enzyme responsible for detoxification and metabolism of endogenous and exogenous lipophilic compounds, such as potentially neurotoxic bilirubin and the anticancer drug irinotecan SN-38, via con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858586d0b8aa0188065fc1786b61c44a
https://doi.org/10.1007/s00210-007-0226-y
https://doi.org/10.1007/s00210-007-0226-y
Autor:
Tomoko Narita, Masaki Ri, Shinsuke Iida, Shiori Kinoshita, Takashi Ishida, Asahi Ito, Reham Ashour, Makoto Osabe, Masahiro Tohkin, Ayako Masaki, Shigeru Kusumoto, Haruhito Totani, Hirokazu Komatsu, Takashi Yoshida
Publikováno v:
Blood. 128:4408-4408
Background: Several studies have demonstrated that aberrant expression of microRNAs in multiple myeloma (MM) cells is associated with the pathogenesis and development of MM. Recently, circulating serum microRNAs have been recognized as novel biomarke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f47a8241ec4db499a34aeb85197e82c1
https://doi.org/10.1182/blood.v128.22.4408.4408
https://doi.org/10.1182/blood.v128.22.4408.4408