Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Makoto Nishie"'
Autor:
Makoto Yoshimoto, Koichi Wakabayashi, Makoto Nishie, Akiyoshi Kakita, Fumiaki Mori, Hitoshi Takahashi
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 65:808-815
The histologic hallmark of Parkinson disease (PD) is loss of pigmented neurons in the substantia nigra (SN) and locus ceruleus (LC) with accumulation of alpha-synuclein (alphaS). It has been reported that tyrosine hydroxylase (TH)-negative pigmented
Disseminated intraparenchymal microgranulomas in the brainstem in central nervous system sarcoidosis
Autor:
Kozo Kurahashi, Fumiaki Mori, Mitsuomi Kaimori, Makoto Nishie, Koichi Wakabayashi, Chieko Suzuki, Masaya Ogawa
Publikováno v:
Neuropathology. 25:361-364
We report a 70-year-old woman with sarcoidosis and multiple cranial nerve palsy. The patient suffered from dysarthria, dysphagia and weakness of the upper and lower extremities and died of sepsis. No abnormalities were noted in brain MRI. At autopsy,
Autor:
Hoyu Takahashi, Koichi Wakabayashi, Katsumi Kito, Yue-Shan Piao, Fumiaki Mori, Tetsu Kamitani, Makoto Nishie
Publikováno v:
Neuropathology and Applied Neurobiology. 31:53-61
NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) is a ubiquitin-like protein that controls vital biological events through its conjugation to members of the cullin family, which are components of certain ubiquitin E3 ligases.
Publikováno v:
Neuropathology. 24:315-319
The case reported here relates to a male infant with hydranencephaly who was born at 37 weeks of gestation and died immediately after birth. Post-mortem examination revealed that the cerebral hemispheres had been replaced by fluid-filled cavities wit
Publikováno v:
Neuropathology and Applied Neurobiology. 30:546-554
Multiple system atrophy (MSA) is a sporadic neurodegenerative disease characterized by the presence of neuronal and oligodendroglial alpha-synuclein aggregates. To investigate the relationship between the occurrence of neuronal cytoplasmic and intran
Autor:
Takeshi Iwatsubo, Masato Hasegawa, Koichi Wakabayashi, Makoto Nishie, Makoto Yoshimoto, Hideo Fujiwara, Hitoshi Takahashi, Fumiaki Mori
Publikováno v:
Acta Neuropathologica. 107:292-298
We immunohistochemically examined the brain and peripheral sympathetic ganglia from eight patients with multiple system atrophy (MSA), using an antibody specific for phosphorylated alpha-synuclein (anti-PSer129). Phosphorylated alpha-synuclein was de
Publikováno v:
NeuroReport. 14:1783-1786
Alpha-Synuclein is a major component of neuronal and glial cytoplasmic inclusions in multiple system atrophy (MSA), one of the alpha-synucleinopathies. Recent studies have shown that beta-synuclein, a homolog of alpha-synuclein, inhibits alpha-synucl
Publikováno v:
Internal Medicine. 42:750-755
A case of cyclosporin A (Cys A)-induced posterior encephalopathy developed into persistent abulia despite rapid and marked improvement of abnormal T2- and FLAIR MRI hyperintense regions. Diffusion-weighted MRI signal intensity was also high at the on
Autor:
Masayuki Nakamura, Akira Sano, Mio Ichiba, Koichi Wakabayashi, Yasuo Miki, Makoto Nishie, Mitsuomi Kaimori, Masaya Ogawa, Fumiaki Mori
Publikováno v:
Acta Neuropathologica. 119:271-273
Chorea-acanthocytosis (ChAc) is caused by loss of function mutations of VPS13A gene encoding the large disease protein named chorein [8, 10]. However, McLeod syndrome, Huntington’s disease-like 2, and pantothenate kinase-associated neurodegeneratio
Autor:
Makoto Nishie, Ryo Nasushita, Hajime Watanobe, Nobuo Horiba, Toshihiro Suda, Kazunori Kageyama
Publikováno v:
Internal Medicine. 37:472-475
We describe an unusual patient with hypopituitarism who attained tall stature even without growth hormone (GH). A 37-year-old man was devoid of secondary sexual characteristics, but manifested tall stature with a eunuchoidal feature. Serum levels of