Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Makoto Nagakura"'
Publikováno v:
BioMed Research International, Vol 2016 (2016)
BioMed Research International
BioMed Research International
The importance of personalized medicine and healthcare is becoming increasingly recognized. Genetic polymorphisms associated with potential risks of various human genetic diseases as well as drug-induced adverse reactions have recently been well stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc61a27de6f8b3b53c17f8898ff40492
https://doi.org/10.1155/2016/7670483
https://doi.org/10.1155/2016/7670483
Publikováno v:
New Horizons in Predictive Drug Metabolism and Pharmacokinetics ISBN: 9781849738286
In addition to drug-metabolizing enzymes, drug transporters are important factors for determining the pharmacokinetic profiles of drugs and, by extension, greatly affect the overall pharmacological or adverse effects of drugs. Among a variety of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0183f513988e1389ca387f24d7bd52c
https://doi.org/10.1039/9781782622376-00333
https://doi.org/10.1039/9781782622376-00333
Autor:
Masato Kitajima, Hikaru Saito, Hiroyuki Hirano, Atsuo Kurata, Aki Sakurai, Yuko Onishi, Shigeki Tarui, Toshihisa Ishikawa, Makoto Nagakura, Yoichi Kanamori, Hiroshi Nakagawa
Publikováno v:
Molecular Pharmaceutics. 3:252-265
Human ATP-binding cassette transporter ABCB11 (SPGP/BSEP) mediates the elimination of bile salts from liver cells and thereby plays a critical role in the generation of bile flow. In the present study, we have developed in vitro high-speed screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f38b1e5c87d75b23dbb92de0ebdf1ad
https://doi.org/10.1021/mp060004w
https://doi.org/10.1021/mp060004w
Autor:
Hiroshi Nakagawa, Mami Konomi, Hiroyuki Hirano, Noboru Tsujikawa, Hikaru Saito, Toshihisa Ishikawa, Makoto Nagakura, Masako Osumi, Kaori Murakami, Takeaki Fukami, Eriko Tao, Shigeki Tarui, Keisuke Oosumi, Takayuki Kouchi, Hiroko Kimura
Publikováno v:
J. Pharmacol. Exp. Ther.. 317(3):1114-1124
The human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR1/ABCP) plays a critical role in cellular protection against xenobiotics as well as pharmacokinetics of drugs in our body. In the present study, we aimed to analyze the quantitative stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42748c26175eedec2eae37f88f2baf49
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100532027
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100532027
Autor:
Toshihisa Ishikawa, Makoto Nagakura, Shigeki Tarui, Hiroyuki Hirano, Yuko Onishi, Keisuke Oosumi
Publikováno v:
Biological and Pharmaceutical Bulletin. 27:939-948
In the 21st century, emerging genomic technologies (i.e., bioinformatics, functional genomics, and pharmacogenomics) are shifting the paradigm of drug discovery research and improving the strategy of medical care for patients. In order to realize the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8a41539c9e4863ae072c5d7240ccf1
https://doi.org/10.1248/bpb.27.939
https://doi.org/10.1248/bpb.27.939
Autor:
Shigeki Tarui, Keisuke Oosumi, Toshihisa Ishikawa, Makoto Nagakura, Kunio Nakata, Hiroyuki Hirano, Yuko Onishi
Publikováno v:
Chem-Bio Informatics Journal. 3:175-193
Human ABCB1 (P-glycoprotein or MDR1) mediates the elimination of a variety of drugs from cells and thereby plays a critical role in determining the pharmacokinetic profiles of drugs in our body. In the present study, we have developed a high-speed sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beb3a693db550b26a237b4d72a8652b1
https://doi.org/10.1273/cbij.3.175
https://doi.org/10.1273/cbij.3.175
Autor:
Toshihisa, Ishikawa, Aki, Sakurai, Yoichi, Kanamori, Makoto, Nagakura, Hiroyuki, Hirano, Yutaka, Takarada, Kazunari, Yamada, Kazuhisa, Fukushima, Masato, Kitajima
Publikováno v:
Methods in enzymology. 400
Drug transporters represent an important mechanism in cellular uptake and efflux of drugs and their metabolites. Hitherto a variety of drug transporter genes have been cloned and classified into either solute carriers or ATP-binding cassette (ABC) tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ed036bc8d55a5686fc5d187679ea6f8
https://pubmed.ncbi.nlm.nih.gov/16399366
https://pubmed.ncbi.nlm.nih.gov/16399366
Autor:
Kazunari Yamada, Hiroyuki Hirano, Yutaka Takarada, Toshihisa Ishikawa, Makoto Nagakura, Kazuhisa Fukushima, Masato Kitajima, Aki Sakurai, Yoichi Kanamori
Drug transporters represent an important mechanism in cellular uptake and efflux of drugs and their metabolites. Hitherto a variety of drug transporter genes have been cloned and classified into either solute carriers or ATP‐binding cassette (ABC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e677c50a5ced485bbd8070379c8a7af
https://doi.org/10.1016/s0076-6879(05)00027-3
https://doi.org/10.1016/s0076-6879(05)00027-3
Publikováno v:
BioMed Research International; 1/1/2016, Vol. 2016, p1-9, 9p