Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Makoto Moriwaki"'
Autor:
Iichiro Shimomura, Toshiaki Hanafusa, Akihisa Imagawa, Kohei Okita, K. Sayama, Hiromi Iwahashi, Jun-ichiro Miyagawa, Shinichi Tamura, Sae Uno, Makoto Moriwaki, Kazuya Yamagata, Yuji Matsuzawa
Publikováno v:
Diabetologia. 50:596-601
Type 1A diabetes results from autoimmune destruction of pancreatic beta cells. We examined the involvement of TNF-alpha and IL-1beta, as well as of T cells, macrophages and dendritic cells, in the destruction of beta cells in patients with recent-ons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f14b77e7b0cd7defa4dec584ff40da1
https://doi.org/10.1007/s00125-006-0569-9
https://doi.org/10.1007/s00125-006-0569-9
Autor:
Akihisa Imagawa, Eiji Kurokawa, Hiromi Iwahashi, Tohru Funahashi, Hiroyuki Toyoshima, Ken Kishida, Yuji Matsuzawa, Jun-ichiro Miyagawa, Junji Kozawa, Tohru Yoshizumi, Kimiko Itoh, Satoshi Umemura, Takashi Kondo, Kohei Okita, Makoto Moriwaki, Kazuya Yamagata, Takao Maruyama
Publikováno v:
Internal Medicine. 42:996-1005
A 34-year-old man was diagnosed with clinical Gushing's syndrome based on circadian fluctuation of plasma adrenocorticotropin and serum cortisol levels and Liddle's-method. The presence of ectopic adrenocorticotropin production was suspected. Urine 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228041c4eb1717af084ca70aa26f3749
https://doi.org/10.2169/internalmedicine.42.996
https://doi.org/10.2169/internalmedicine.42.996
Autor:
Jun-ichiro Miyagawa, Masako Waguri, Sumio Kawata, Akihisa Imagawa, Shinji Tamura, Takao Nanmo, Naoto Itoh, Makoto Moriwaki, Yuji Matsuzawa, Kazuya Yamagata, Hiromi Iwahashi, Koji Yamamoto, Mitsuyoshi Namba, Hiromu Nakajima, Toshiaki Hanafusa, Sae Uno
Publikováno v:
Diabetes. 50:1269-1273
To better understand the pathogenesis of type 1 diabetes, we have developed pancreatic biopsy under laparoscope for recent-onset type 1 diabetic patients. The patients included 29 acute-onset type 1 diabetic patients, 5 latent-onset type 1 diabetic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fa438a4938653c728a548efbd3f6930
https://doi.org/10.2337/diabetes.50.6.1269
https://doi.org/10.2337/diabetes.50.6.1269
Autor:
Toshiaki Hanafusa, Yuji Matsuzawa, Takao Nammo, Reiko Sasada, Masako Waguri, Koji Yamamoto, Mitsuyoshi Namba, Yoshihiro Tochino, Makoto Moriwaki, Akihisa Imagawa, Jun-ichiro Miyagawa, Kazuya Yamagata, Hiromu Nakajima, Ming Li, Koichi Igarashi
Publikováno v:
Diabetes. 49:2021-2027
Betacellulin (BTC), a member of the epidermal growth factor family, is expressed predominantly in the human pancreas and induces the differentiation of a pancreatic acinar cell line (AR42J) into insulin-secreting cells, suggesting that BTC has a phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21a3f7b61a54e08598f52bf64c0f427
https://doi.org/10.2337/diabetes.49.12.2021
https://doi.org/10.2337/diabetes.49.12.2021
Autor:
Shigekazu Nagata, Jun-ichiro Miyagawa, K. Yamamoto, Mitsuyoshi Namba, Yuji Matsuzawa, T. Hanafusa, Akihisa Imagawa, H. Nakajima, Makoto Moriwaki, Kazuya Yamagata, Hiromi Iwahashi, Naoto Itoh
Publikováno v:
Diabetologia. 42:1332-1340
Aims/hypothesis. Type I (insulin-dependent) diabetes results mainly from T-cell-mediated autoimmune destruction of pancreatic beta cells. Cytotoxic T lymphocytes destroy target cells via a perforin-based or Fas-based mechanism. Our previous study ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e26924e6ce235591c4add2fde0c07bc
https://doi.org/10.1007/s001250051446
https://doi.org/10.1007/s001250051446
Autor:
Jun-ichiro Miyagawa, Toshiaki Hanafusa, Yoshimitsu Yamasaki, Naoyuki Taniguchi, Junichi Fujii, Koji Yamamoto, Yuji Matsuzawa, Reiko Hamaoka, Michihiko Kishimoto, Yoshitaka Kajimoto, Motoko Takahashi, Makoto Moriwaki
Publikováno v:
Journal of Biochemistry. 126:41-47
To determine the role of the polyol metabolizing pathway under hyperglycemic conditions, the effects of aldose reductase (AR) on the cellular functions of pancreatic beta-cells were examined. Stable transfectants of rat AR cDNA were obtained with a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2449964806a2ceb7220289596f43230
https://doi.org/10.1093/oxfordjournals.jbchem.a022434
https://doi.org/10.1093/oxfordjournals.jbchem.a022434
Autor:
T. Tsuji, K. Yamamoto, Yuji Matsuzawa, H. Nakajima, Makoto Moriwaki, Akihisa Imagawa, Hiromi Iwahashi, M. Sada, Masamichi Kuwajima, Kazuya Yamagata, Shinichi Tamura, Jun-ichiro Miyagawa, Masako Waguri, Sumio Kawata, Naoto Itoh, Mitsuyoshi Namba, T. Hanafusa
Publikováno v:
Diabetologia. 42:574-578
Aims/hypothesis. To determine whether the clinical heterogeneity observed in the development of Type I (insulin-dependent) diabetes mellitus correlates with immunohistochemical differences observed at diagnosis. Methods. Patients (n = 17) with recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d84827b1fd4c525cdb036e6ff706a0c
https://doi.org/10.1007/s001250051197
https://doi.org/10.1007/s001250051197
Autor:
K. Yamamoto, Mitsuyoshi Namba, Makoto Moriwaki, Akihisa Imagawa, Kazuya Yamagata, Masako Waguri, H. Nakajima, Koji Tomita, Jun-ichiro Miyagawa, Naoto Itoh, Issei Yoshiuchi, Yuji Matsuzawa, T. Hanafusa, Hiromi Iwahashi, Takao Nanmo
Publikováno v:
Emerging Therapeutic Targets. 3:177-193
(1999). Emerging therapeutic strategies in autoimmune diabetes: aetiology, prediction, prevention and cure. Emerging Therapeutic Targets: Vol. 3, No. 1, pp. 177-193.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16daf2fcae4be1e46d7abf620adb721
https://doi.org/10.1517/14728222.3.1.177
https://doi.org/10.1517/14728222.3.1.177
Autor:
Shigekazu Nagata, Toshiaki Hanafusa, Mitsuyoshi Namba, Hiromi Iwahashi, Akihisa Imagawa, Jun-ichiro Miyagawa, Makoto Moriwaki, Koji Yamamoto, Hiromu Nakajima, Yuji Matsuzawa, Masako Waguri, Susumu Makino, Norio Kono, Naoto Itoh
Publikováno v:
The Journal of Experimental Medicine
Insulin-dependent diabetes mellitus (IDDM) is assumed to be a T cell–mediated autoimmune disease. To investigate the role of Fas-mediated cytotoxicity in pancreatic β cell destruction, we established nonobese diabetic (NOD)-lymphoproliferation (lp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e82a82895505aae98be5dcd4ef16e3
http://europepmc.org/articles/PMC2199040
http://europepmc.org/articles/PMC2199040
Autor:
Hiroshi Ohmoto, Jun Zhang, Ming Li, Jun-ichiro Miyagawa, Hiromi Iwahashi, Ming Yuan, Iichiro Shimomura, Yae Tokui, Makoto Moriwaki, Yoshihiro Tochino, Akihisa Imagawa, Kazuya Yamagata, Shigeki Higashiyama, Junji Kozawa
Publikováno v:
Pancreas. 31(1)
In the adult pancreas, pre-existing beta cells, stem cells, and endocrine progenitor cells residing in the duct lining are considered important sources for beta-cell regeneration. A member of the epidermal growth factor (EGF) family, heparin binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2364ae03b8ed5d903a8980558861285d
https://pubmed.ncbi.nlm.nih.gov/15968245
https://pubmed.ncbi.nlm.nih.gov/15968245