Zobrazeno 1 - 10
of 224
pro vyhledávání: '"Makoto Michikawa"'
Autor:
Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yang Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga, Makoto Michikawa
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-10 (2023)
Abstract Our previous study showed that the flotillin level is decreased in the blood of patients with Alzheimer’s disease (AD) when compared to that of patients with non-AD and vascular dementia; however, the molecular mechanism remains to be dete
Externí odkaz:
https://doaj.org/article/05c0118f6d794355858bce286552e92e
Autor:
Mona Abdelhamid, Cha-Gyun Jung, Chunyu Zhou, Rieko Inoue, Yuxin Chen, Yoshiki Sento, Hideki Hida, Makoto Michikawa
Publikováno v:
Nutrients, Vol 16, Iss 4, p 538 (2024)
We previously demonstrated that orally supplemented Bifidobacterium breve MCC1274 (B. breve MCC1274) mitigated Alzheimer’s disease (AD) pathologies in both 7-month-old AppNL-G-F mice and wild-type mice; thus, B. breve MCC1274 supplementation might
Externí odkaz:
https://doaj.org/article/2ff9917aebb24695992b0cda13071865
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1757 (2024)
Presenilin, a transmembrane protein primarily known for its role in Alzheimer’s disease (AD) as part of the γ-secretase complex, has garnered increased attention due to its multifaceted functions in various cellular processes. Recent investigation
Externí odkaz:
https://doaj.org/article/d1a30c30941049748a986459c0ee1a87
Autor:
Abu Zaffar Shibly, Abdullah Md. Sheikh, Makoto Michikawa, Shatera Tabassum, Abul Kalam Azad, Xiaojing Zhou, Yuchi Zhang, Shozo Yano, Atsushi Nagai
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 104 (2024)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/2865f76395964b1cb4b1d112e0d6a194
Autor:
Cha-Gyun Jung, Reiko Kato, Chunyu Zhou, Mona Abdelhamid, Esraa Ibrahim A. Shaaban, Hitoshi Yamashita, Makoto Michikawa
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Global warming is a serious public health threat to people worldwide. High body temperature is one of the important risk factors for Alzheimer’s disease (AD), and the body temperature of AD patients has been found to be significantly highe
Externí odkaz:
https://doaj.org/article/f330424fb06a4a9792d424388bbf731a
Autor:
Yuan Gao, Yang Sun, Sadequl Islam, Tomohisa Nakamura, Taisuke Tomita, Kun Zou, Makoto Michikawa
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAlzheimer’s disease (AD) is associated with amyloid β-protein 1-42 (Aβ42) accumulation in the brain. Aβ42 and Aβ40 are the major two species generated from amyloid precursor protein. We found that angiotensin-converting enzyme (ACE)
Externí odkaz:
https://doaj.org/article/1cb3d4484e2f4f52ae2a4c15b051d2d1
Autor:
Kun Zou, Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Hiroto Komano, Taisuke Tomita, Makoto Michikawa
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) is a genetic and sporadic neurodegenerative disease characterized by extracellular amyloid-β-protein (Aβ) aggregates as amyloid plaques and neuronal loss in the brain parenchyma of patients. Familial AD (FAD) is found to
Externí odkaz:
https://doaj.org/article/b1ed4283d0c34a38b03026aceee3a6b5
Autor:
Abdullah Md. Sheikh, Shozo Yano, Shatera Tabassum, Shingo Mitaki, Makoto Michikawa, Atsushi Nagai
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4510 (2023)
Increased angiogenesis, especially the pathological type, has been documented in Alzheimer’s disease (AD) brains, and it is considered to be activated due to a vascular dysfunction-mediated hypoxic condition. To understand the role of the amyloid
Externí odkaz:
https://doaj.org/article/0ff9267c1bc142f58fe9eb2223e10e05
Autor:
Cha-Gyun Jung, Hitoshi Yamashita, Reiko Kato, Chunyu Zhou, Hiroaki Matsushita, Tamaki Takeuchi, Mona Abdelhamid, Yuxin Chen, Makoto Michikawa
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2741 (2023)
We previously demonstrated that the Alzheimer’s disease (AD)-like model mice, Tg2576, housed at a high ambient temperature of 30 °C for 13 months, exhibited increased body temperature, which increased amyloid-β (Aβ) levels and tau stability, lea
Externí odkaz:
https://doaj.org/article/192123205b6b4e279e3186225f66a5f8
Autor:
Abu Zaffar Shibly, Abdullah Md. Sheikh, Makoto Michikawa, Shatera Tabassum, Abul Kalam Azad, Xiaojing Zhou, Yuchi Zhang, Shozo Yano, Atsushi Nagai
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 50 (2022)
Amyloid β (Aβ) peptide is deposited in the brains of sporadic Alzheimer’s disease (AD) due to impaired vessel-dependent clearance. To understand the mechanisms, we investigated time-dependent cerebrovascular changes in AD model mice. Cerebrovascu
Externí odkaz:
https://doaj.org/article/2f30aa809c574cd29fd9703b5a6e4f66