Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Makoto MASUMURA"'
Autor:
Chie Takano, Takuma Takano, Makoto Masumura, Ryuichi Nakamura, Shuichi Koda, Hiroki Bochimoto, Shigetaka Yoshida, Yoshio Bando
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8160 (2023)
Multiple sclerosis (MS) is the chronic inflammatory demyelinating disease of the CNS. Relapsing–remitting MS (RRMS) is the most common type of MS. However, the mechanisms of relapse and remission in MS have not been fully understood. While SJL mice
Externí odkaz:
https://doaj.org/article/8eee6a235d444bdb84aa0ccb19e36643
Autor:
Akihiro Fujikawa, Hajime Sugawara, Taisaku Tanaka, Masahito Matsumoto, Kazuya Kuboyama, Ryoko Suzuki, Naomi Tanga, Atsuto Ogata, Makoto Masumura, Masaharu Noda
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
Abstract The R5 subfamily of receptor-type protein tyrosine phosphatases (RPTPs) comprises PTPRZ and PTPRG. A recent study on primary human glioblastomas suggested a close association between PTPRZ1 (human PTPRZ) expression and cancer stemness. Howev
Externí odkaz:
https://doaj.org/article/6fee56b055c14364a010dc2e318654be
Autor:
Kazuya Kuboyama, Akihiro Fujikawa, Makoto Masumura, Ryoko Suzuki, Masahito Matsumoto, Masaharu Noda
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48797 (2012)
BACKGROUND: Fyn tyrosine kinase-mediated down-regulation of Rho activity through activation of p190RhoGAP is crucial for oligodendrocyte differentiation and myelination. Therefore, the loss of function of its counterpart protein tyrosine phosphatase
Externí odkaz:
https://doaj.org/article/27feb43a6e464af0b7b3698e1498b048
Autor:
Hiroshi Kamiyama, Mieko Nagakura, Masataka Taguri, Noriko Akema, Masanao Oka, Tadashi Furuie, Makoto Masumura, Kazutaka Aoki, Shigeru Nakajima, Kazunari Kamiko, Yasuo Terauchi
Publikováno v:
Journal of Clinical Medicine Research
Background: Patients with type 2 diabetes mellitus often take multiple anti-diabetic drugs for a long period. Fixed dose combination (FDC) therapy is expected to improve drug adherence for patients with diabetes. The effect of switching from a loose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2620da474e22b1bb1b0b571d6c398688
http://europepmc.org/articles/PMC5505309
http://europepmc.org/articles/PMC5505309
Autor:
Yoshikazu Arai, Katsushi Katayama, Makoto Masumura, Tsutomu Nagata, Hiroyuki Okada, Shuichi Koda, Shoichi Saito, Ayako Yoshida, Tsuyoshi Muto, Kouhei Takashima, Kenji Murata
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115348
A novel series of spiroindoline derivatives was discovered for use as inducers of oligodendrocyte progenitor cell (OPC) differentiation, resulting from optimization of screening hit 1. Exploration of structure-activity relationships led to compound 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282a7d5cd5b8441fbd2cd803bc5f8643
https://doi.org/10.1016/j.bmc.2020.115348
https://doi.org/10.1016/j.bmc.2020.115348
Autor:
Akihiro Fujikawa, Masanori Noda, Hajime Sugawara, Kazuya Kuboyama, Susumu Uchiyama, Ryoko Suzuki, Atsuto Ogata, Makoto Masumura, Toshiyuki Tomoo, Seiichi Imajo, Asako Nagahira, Naomi Tanga, Kentaro Ishii, Masaharu Noda, Masahito Matsumoto
Publikováno v:
Scientific Reports
Protein tyrosine phosphatase receptor-type Z (PTPRZ) is aberrantly over-expressed in glioblastoma and a causative factor for its malignancy. However, small molecules that selectively inhibit the catalytic activity of PTPRZ have not been discovered. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6206b4b828a9cb689dc9e094c5847dc1
Autor:
Takahiro Suemoto, Tohru Sawada, Hiroyasu Akatsu, Takayuki Yamamoto, Takahiro Nakayama, Kenji Kosaka, Ryuji Hata, Feng Li, Yasuo Nagai, Makoto Masumura, Klaus Heese
Publikováno v:
European Journal of Neuroscience. 15:79-86
The treatment of Alzheimer's disease (AD) remains a major challenge because of the incomplete understanding of the triggering events that lead to the selective neurodegeneration characteristic of AD brains. Here we describe a new protein, CGI-94, tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c420eb21da93aa772fc5235e0b6d3048
https://doi.org/10.1046/j.0953-816x.2001.01836.x
https://doi.org/10.1046/j.0953-816x.2001.01836.x
Up-Regulation of Calcineurin Aβ mRNA in the Alzheimer's Disease Brain: Assessment by cDNA Microarray
Autor:
Tohru Sawada, Takayuki Yamamoto, Yasuo Nagai, Hiroko Fujita, Masahiro Sakanaka, Hidechika Okada, Ryuji Hata, Hiroyasu Akatsu, Kenji Kosaka, Makoto Masumura, Feng Li
Publikováno v:
Biochemical and Biophysical Research Communications. 284:310-316
Recent advances in cDNA microarray technology have made it possible to analyze expression of more than 8000 genes. Using this technology, gene expression in the hippocampus containing neurofibrillary tangle-associated lesions from an Alzheimer's dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd941d2c2214ecfb057b2073cd60b282
https://doi.org/10.1006/bbrc.2001.4968
https://doi.org/10.1006/bbrc.2001.4968
Autor:
Tohru Sawada, Takayuki Yamamoto, Kenji Kosaka, Makoto Masumura, Yasuo Nagai, Ryuji Hata, Hiroyasu Akatsu
Publikováno v:
Journal of Stroke and Cerebrovascular Diseases. 10:55-62
Increasing evidence suggests the presence of apoptotic cell death in many neurodegenerative diseases. However, in Binswanger's disease (BD), no information is available concerning the apoptosis-related pathologic changes that may occur in the white m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d081c75da7447947ca8fe40c304f50
https://doi.org/10.1053/jscd.2001.24660
https://doi.org/10.1053/jscd.2001.24660
Publikováno v:
Molecular Brain Research. 80:219-227
To elucidate the mechanism of neuronal death in Alzheimer's disease, we investigated the effects of overexpression of wild-type Alzheimer amyloid precursor protein (APP) on neuronal cells and glial cells in vivo. When an APP695-expressing adenovirus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672eb0c2d7a851ae25e591afa75849c1
https://doi.org/10.1016/s0169-328x(00)00163-7
https://doi.org/10.1016/s0169-328x(00)00163-7