Zobrazeno 1 - 10
of 586
pro vyhledávání: '"Makoto Kuro-o"'
Autor:
Serafima Dubnov, Estelle R. Bennett, Nadav Yayon, Or Yakov, David A. Bennett, Sudha Seshadri, Elliott Mufson, Yonat Tzur, David Greenberg, Makoto Kuro-o, Iddo Paldor, Carmela R. Abraham, Hermona Soreq
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Overexpression of the longevity gene Klotho prolongs lifespan, while its knockout shortens lifespan and impairs cognition via perturbation of myelination and synapse formation. However, comprehensive analysis of Klotho knockout effects on ma
Externí odkaz:
https://doaj.org/article/3ebc2e4dc2b14899a640933ae8c12b98
Autor:
Eisuke Ochi, Alice Barrington, Michelle Wehling‐Henricks, Marcus Avila, Makoto Kuro‐o, James G. Tidball
Publikováno v:
Experimental Physiology, Vol 108, Iss 12, Pp 1531-1547 (2023)
Abstract Muscle growth is influenced by changes in the mechanical environment that affect the expression of genes that regulate myogenesis. We tested whether the hormone Klotho could influence the response of muscle to mechanical loading. Applying me
Externí odkaz:
https://doaj.org/article/36546edd455344778245b9c415eadd9e
Autor:
Marina Miura, Yutaka Miura, Yoshitaka Iwazu, Hideyuki Mukai, Takahiro Sugiura, Yuji Suzuki, Masami Kato, Mayumi Kano, Daisuke Nagata, Kazuhiro Shiizaki, Hiroshi Kurosu, Makoto Kuro-o
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Hyperphosphatemia is a major risk for poor prognosis in patients with end-stage renal disease. However, the molecular mechanism behind this link remains elusive. We and others have demonstrated that serum phosphorus levels correlate positive
Externí odkaz:
https://doaj.org/article/e2060f24832b44d682eb306226d61edb
Autor:
Takeshi Tadokoro, Akihiko Kato, Hiromitsu Ohmori, Tomio Matsumoto, Makoto Kuro-O, Tsuyoshi Kobayashi, Hideki Ohdan
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 12, p 3491 (2024)
Background/Objectives: Levels of circulating soluble thrombomodulin (sTM), an anticoagulant factor, are associated with the severity and progression of arteriosclerotic diseases. However, the role of elevated sTM levels remains to be clarified in pat
Externí odkaz:
https://doaj.org/article/56c878054ca34234bcd1692d62178e2c
Autor:
Keisei Kosaki, Jiyeon Park, Masahiro Matsui, Takeshi Sugaya, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Seiji Maeda
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Inappropriate activation of intrarenal renin–angiotensin system (RAS) may contribute to the pathogenesis of cardio-renal syndrome (CRS). We aimed to examine the cross-sectional associations of urinary angiotensinogen (AGT) excretion, a bio
Externí odkaz:
https://doaj.org/article/940e71416a5a4a7c9d455585b4bd8fb0
Autor:
Nourin Jahan, Hiroyuki Ohsaki, Kiyoko Kaneko, Asadur Rahman, Takeshi Nishiyama, Makoto Koizumi, Shuichiro Yamanaka, Kento Kitada, Yuki Sugiura, Kenji Matsui, Takashi Yokoo, Takayuki Hamano, Makoto Kuro-o, Takuya Itou, Miwa Suzuki, Keiichi Ueda, Akira Nishiyama
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract This study aimed to investigate whether phosphate contributes to the pathogenesis of chronic kidney disease (CKD) in dolphins. Renal necropsy tissue of an aged captive dolphin was analyzed and in vitro experiments using cultured immortalized
Externí odkaz:
https://doaj.org/article/012b64be875745bba67c6ca815f50a15
Autor:
Masaki Yoshioka, Keisei Kosaki, Shunta Noma, Masahiro Matsui, Makoto Kuro-O, Ai Shibata, Chie Saito, Kunihiro Yamagata, Koichiro Oka, Seiji Maeda
Publikováno v:
Experimental Gerontology, Vol 183, Iss , Pp 112315- (2023)
Externí odkaz:
https://doaj.org/article/e396b95206a44b60bdcde3131ed50d17
Autor:
Batpurev Battulga, Kazuhiro Shiizaki, Yutaka Miura, Yasuyuki Osanai, Reiji Yamazaki, Yoshiaki Shinohara, Yoshiyuki Kubota, Toru Hara, Makoto Kuro-o, Nobuhiko Ohno
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Calcium phosphate forms particles under excessive urinary excretion of phosphate in the kidney. While the formation of calcium phosphate particles (CaPs) has been implicated in the damage to renal tubular cells and renal dysfunction, clarify
Externí odkaz:
https://doaj.org/article/fddb7b93816940fa872bab55680acdd8
Autor:
Hideyuki Mukai, Yutaka Miura, Kazuhiko Kotani, Atsushi Kotoda, Hiroshi Kurosu, Toshiyuki Yamada, Makoto Kuro-o, Yoshitaka Iwazu
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Calciprotein particles (CPPs) are colloids composed of solid-phase calcium-phosphate and serum protein fetuin-A. CPPs form a polydispersed system with different particle size and density. CPPs with specific physical properties can induce cal
Externí odkaz:
https://doaj.org/article/666f25b9276e4875b95681cfdf8104a6
Autor:
Natsumi Nishitani, Keisei Kosaki, Shoya Mori, Masahiro Matsui, Takeshi Sugaya, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Seiji Maeda
Publikováno v:
Geriatrics, Vol 8, Iss 6, p 118 (2023)
Age-related loss of lower extremity muscle strength is pronounced in individuals with chronic kidney disease (CKD). In contrast, an increase in intrarenal flow pulsatility results in initial age-related changes in renal hemodynamics, leading to the d
Externí odkaz:
https://doaj.org/article/20244606f3d846f8bfeff949b9df4e78