Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Makoto Kunisaki"'
Autor:
Yasuhiro Ono, Makoto Kunisaki, Hajime Nawata, Fumio Umeda, Naotaka Sekiguchi, Toshihiko Hashimoto
Publikováno v:
Diabetologia. 41:134-140
Prostacyclin (PGI2) is a potent vasoactive prostanoid regulating vascular tone. We recently purified and cloned a PGI2-stimulating factor (PSF), which stimulates PGI2 production by vascular endothelial cells (ECs). Previous study demonstrated that PS
Publikováno v:
BioFactors. 7:55-67
Hyperglycemia in diabetes mellitus has been shown to activate diacylglycerol (DAG)-protein kinase C (PKC) pathway in the vascular tissues, possibly altering vascular function. We have characterized the effects of vitamin E (d-alpha-tocopherol) on act
Publikováno v:
Scopus-Elsevier
Hyperglycemia is the major causal factor in the development of diabetic vascular complications. The mechanism by which hyperglycemia causes the complications is not clear; however, it is very likely that hyperglycemia is mediating its adverse effects
Autor:
Hidehiro Ishii, George L. King, H. Nawata, S E Bursell, F. Umeda, Makoto Kunisaki, M. R. Jirousek, Allen C. Clermont, L. M. Ballas
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 269:E239-E246
We have characterized effects of d-alpha-tocopherol (vitamin E) on activation of protein kinase C (PKC) and diacylglycerol (DAG) levels in retinal tissues of diabetic rats and correlated its effects to diabetes-induced changes in retinal hemodynamics
Autor:
Fumio Umeda, Teruaki Yamauchi, Hajime Nawata, Yasuhiro Ono, Makoto Kunisaki, Mitsunori Masakado
Publikováno v:
Journal of Clinical Biochemistry and Nutrition. 19:1-7
We evaluated the effect of vitamin E on the growth of cultured bovine aortic endothelial cells (BAEC). A high concentration of glucose (≥200mg/dl) in the culture medium reduced the replication of BAEC. Addition of vitamin E at a physiological conce
Publikováno v:
Diabetes. 43:1372-1377
Hyperglycemia and diabetes have been shown to increase diacylglycerol (DAG) level and activate protein kinase C (PKC) activity in the vascular tissues, possibly altering vascular function. We have characterized the effects of D-α-tocopherol (vitamin
Publikováno v:
Scopus-Elsevier
We have reported that membranous protein kinase C (PKC) activities and total diacylglycerol (DAG) levels are increased in the heart and aorta of diabetic rats, which cannot be easily reversed by euglycemic control. However, insulin treatment, which a
Publikováno v:
Diabetes. 42:1138-1146
We investigated the effects of glucose on specific D-alpha-tocopherol binding to cultured bovine aortic endothelial cells. Our results confirmed that cultured bovine aortic endothelial cells have specific binding sites for D-alpha-tocopherol. These b