Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Makoto Ita"'
Autor:
Toshiya Sato, Kanako Oda, Seiko Sakai, Rika Kato, Saori Yamamori, Makoto Itakura, Yoshio Kodera, Masatoyo Nishizawa, Toshikuni Sasaoka, Osamu Onodera, Minesuke Yokoyama
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract TAR DNA-binding protein 43 kDa (TDP-43), a nuclear protein, plays an important role in the molecular pathogenesis of amyotrophic lateral sclerosis (ALS). The long-disordered C-terminal region (CTR) of TDP-43 is known to be aggregation-prone
Externí odkaz:
https://doaj.org/article/419759e22ee04f0e92a2be83c4e71e34
Autor:
Tomohisa Koyama, Kentaro Uchida, Makoto Itakura, Masayuki Miyagi, Ryo Tazawa, Gen Inoue, Kensuke Fukushima, Yoshihisa Ohashi, Ayumi Tsukada, Masashi Takaso
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 7, Pp 3146-3155 (2022)
Expression of the apelin receptor, APJ, in skeletal muscle (SM) is known to decrease with age, but the underlying mechanism remains unclear. Increased tumor necrosis factor (TNF)-α levels are observed in SM with age and are associated with muscle at
Externí odkaz:
https://doaj.org/article/5e8d4c3f56cb408b8970096882664932
Autor:
Shigeru Takeshita, Toshitaka Manda, Shoji Takakura, Ikuo Kawamura, Seitaro Mutoh, Miyuki Mabuchi, Hideaki Minoura, Tadashi Yamamoto, Jiro Hirosumi, Makoto Ita, Jiro Seki
Publikováno v:
European Journal of Pharmacology. 519:182-190
Effect of 3-(2,4-dichlorobenzyl)-2-methyl-N-(pentylsulfonyl)-3H-benzimidazole-5-carboxamide (FK614), a novel nonthiazolidinedione peroxisome proliferator-activated receptor (PPAR) gamma agonist, on glucose tolerance and insulin resistance in peripher
Autor:
Takahiro Kato, Keiichi Fukuda, Makoto Ita, Tsutomu Tanabe, Satoshi Ogawa, Eiichi Takahashi, Mitsushige Murata, Shunichiro Miyoshi
Publikováno v:
Circulation Research. 94:1242-1248
We have previously reported that leukemia inhibitory factor (LIF) gradually increased cardiac L-type Ca 2+ channel current ( I CaL ), which peaked at 15 minutes in both adult and neonatal rat cardiomyocytes, and this increase was blocked by the mitog
Autor:
Sho Inoue, Yuki Inahashi, Makoto Itakura, Gen Inoue, Kyoko Muneshige, Tomoyasu Hirose, Masato Iwatsuki, Masashi Takaso, Masayuki Miyagi, Kentaro Uchida
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13871 (2023)
Synovial inflammation plays a crucial role in the destruction of joints and the experience of pain in osteoarthritis (OA). Emerging evidence suggests that certain antibiotic agents and their derivatives possess anti-inflammatory properties. Medermyci
Externí odkaz:
https://doaj.org/article/422f90b78e25444997c88d5efc50c753
Autor:
Makoto Ita, Kojiro Tanimoto, Kana Fujikura, Yoko Hagiwara, Yukiko Fukuda, Shunichiro Miyoshi, Satoshi Ogawa, Hideo Mitamura
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H1285-H1294
Phase 2 reentry (P2R) is known to be one of the mechanisms of malignant ventricular arrhythmias, especially those associated with Brugada syndrome. However, little is known about the underlying mechanism for P2R. Our aim in this study was to simulate
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Recent mass spectrometry (MS)-based techniques enable deep proteome coverage with relative quantitative analysis, resulting in increased identification of very weak signals accompanied by increased data size of liquid chromatography (LC)–M
Externí odkaz:
https://doaj.org/article/c4b961b0216b4cf98d42bebbb6cc47ec
Autor:
Yuji Yokozeki, Kentaro Uchida, Ayumu Kawakubo, Mitsufumi Nakawaki, Tadashi Okubo, Masayuki Miyagi, Gen Inoue, Makoto Itakura, Hiroyuki Sekiguchi, Masashi Takaso
Publikováno v:
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans. Increase
Externí odkaz:
https://doaj.org/article/4883f062c4c54a20b245cdeaa73fb551
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) is considered to play an important role not only in reward-based learning but also in aversive learning. The contextual and auditory cued fear conditioning tests involve the processing o
Externí odkaz:
https://doaj.org/article/2e306e26c3cb42049245b14a649fc606
Autor:
Shunichirou Miyoshi, Akihiro Umezawa, Tohru Kiyono, Satoshi Gojo, Michiie Sakamoto, Taisuke Mori, Kaoru Segawa, Hideaki Imabayashi, Shinobu Nakamura, Yukiji Takeda, Makoto Ita, Naoko Hida, Satoshi Ogawa
Publikováno v:
The journal of gene medicine. 6(8)
Background Cell transplantation has recently been challenged to improve cardiac function of severe heart failure. Human mesenchymal stem cells (hMSCs) are multipotent cells that can be isolated from adult marrow stroma, but because of their limited l