Zobrazeno 1 - 10
of 796
pro vyhledávání: '"Makoto ARAI"'
Autor:
Tianran Wang, Kazuya Toriumi, Kazuhiro Suzuki, Mitsuhiro Miyashita, Azuna Ozawa, Mayuko Masada, Masanari Itokawa, Makoto Arai
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 4, Pp 728-736 (2024)
Abstract Social dysfunctions are common in various psychiatric disorders, including depression, schizophrenia, and autism, and are long‐lasting and difficult to treat. The development of treatments for social impairment is critical for the treatmen
Externí odkaz:
https://doaj.org/article/46cd7d35b25d4dbaa6fedc25029bff61
Autor:
Koichi Tabata, Shuraku Son, Jun Miyata, Kazuya Toriumi, Mitsuhiro Miyashita, Kazuhiro Suzuki, Masanari Itokawa, Hidehiko Takahashi, Toshiya Murai, Makoto Arai
Publikováno v:
Schizophrenia, Vol 10, Iss 1, Pp 1-7 (2024)
Abstract Several studies have shown white matter (WM) dysconnectivity in people with schizophrenia (SZ). However, the underlying mechanism remains unclear. We investigated the relationship between plasma homocysteine (Hcy) levels and WM microstructur
Externí odkaz:
https://doaj.org/article/4e7d67885dff49229588d0c5a28b2ccc
Autor:
Tzuyao Lo, Itaru Kushima, Hiroki Kimura, Branko Aleksic, Takashi Okada, Hidekazu Kato, Toshiya Inada, Yoshihiro Nawa, Youta Torii, Maeri Yamamoto, Ryo Kimura, Yasuko Funabiki, Hirotaka Kosaka, Shusuke Numata, Kiyoto Kasai, Tsukasa Sasaki, Shigeru Yokoyama, Toshio Munesue, Ryota Hashimoto, Yuka Yasuda, Michiko Fujimoto, Masahide Usami, Masanari Itokawa, Makoto Arai, Kazutaka Ohi, Toshiyuki Someya, Yuichiro Watanabe, Jun Egawa, Tsutomu Takahashi, Michio Suzuki, Hidenori Yamasue, Nakao Iwata, Masashi Ikeda, Norio Ozaki
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 1, Pp 42-50 (2024)
Abstract Aim The present study aimed to examine the association between copy number variations (CNVs) in parkin (PRKN) and schizophrenia (SCZ) and autism spectrum disorder (ASD) in a large case–control sample. Method Array comparative genomic hybri
Externí odkaz:
https://doaj.org/article/7c5247e49f9446b48f67640ae93b6ce0
Autor:
Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, Hyunmi Choi, Ge Yang, Yanan Zhao, Rei Yamaguchi, Hitomi Jin, Hina Sagae, Youichiro Wada, Toshiya Tanaka, Hiroshi Kimura, Tatsuhiko Kodama, Hiroyuki Aburatani, Kazuhisa Takeda, Takeshi Inagaki, Timothy F. Osborne, Takeshi Yoneshiro, Yoshihiro Matsumura, Juro Sakai
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109398- (2024)
Summary: Mitochondria play a vital role in non-shivering thermogenesis in both brown and subcutaneous white adipose tissues (BAT and scWAT, respectively). However, specific regulatory mechanisms driving mitochondrial function in these tissues have be
Externí odkaz:
https://doaj.org/article/04a6729f65d1452297c0ef6f43b6e818
Autor:
Shuraku Son, Makoto Arai, Kazuya Toriumi, Christina Andica, Daisuke Matsuyoshi, Koji Kamagata, Shigeki Aoki, Takahiko Kawashima, Takanori Kochiyama, Tomohisa Okada, Yasutaka Fushimi, Yuji Nakamoto, Yuko Kobayashi, Toshiya Murai, Masanari Itokawa, Jun Miyata
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Carbonyl stress is a condition featuring increased rich reactive carbonyl compounds, which facilitate the formation of advanced glycation end products including pentosidine. We previously reported the relationship between enhanced carbonyl s
Externí odkaz:
https://doaj.org/article/b38a7acf387843b085269d3e6dd0c75e
Autor:
Kenichiro Okimoto, Yosuke Hirotsu, Makoto Arai, Kenji Amemiya, Naoki Akizue, Yuki Ohta, Takashi Taida, Keiko Saito, Hiroshi Ohyama, Tomoaki Matsumura, Motoi Nishimura, Kazuyuki Matsushita, Keisuke Matsusaka, Toshio Oyama, Hitoshi Mochizuki, Tetsuhiro Chiba, Jun Kato, Jun‐ichiro Ikeda, Osamu Yokosuka, Naoya Kato, Masao Omata
Publikováno v:
Cancer Medicine, Vol 12, Iss 7, Pp 8490-8498 (2023)
Abstract Background This study aimed to investigate the validity of pathological diagnosis of early CRC (E‐CRC) from the genetic background by comparing data of E‐CRC to colorectal adenoma (CRA) and The Cancer Genome Atlas (TCGA) on advanced CRC
Externí odkaz:
https://doaj.org/article/0a05a72dd34f4bc99d4eef95784d4b12
Autor:
Kazuya Toriumi, Kyoka Iino, Azuna Ozawa, Mitsuhiro Miyashita, Syudo Yamasaki, Kazuhiro Suzuki, Hikari Sugawa, Koichi Tabata, Satoshi Yamaguchi, Satoshi Usami, Masanari Itokawa, Atsushi Nishida, Ryoji Nagai, Hidenori Kamiguchi, Makoto Arai
Publikováno v:
Redox Biology, Vol 67, Iss , Pp 102876- (2023)
Pentosidine (PEN) is an advanced glycation end-product (AGEs), where a fluorescent cross-link is formed between lysine and arginine residues in proteins. Accumulation of PEN is associated with aging and various diseases. We previously reported that a
Externí odkaz:
https://doaj.org/article/669484f5dbf847fe96284e5f9b8b22ea
Autor:
Yuya Yokoyama, Yuki Ohta, Sadahisa Ogasawara, Jun Kato, Ryoko Arai, Hirotaka Koseki, Masaya Saito, Tatsuya Kaneko, Mamoru Tokunaga, Hirotaka Oura, Tsubasa Oike, Yushi Imai, Kengo Kanayama, Naoki Akizue, Junichiro Kumagai, Takashi Taida, Kenichiro Okimoto, Keiko Saito, Yoshihiko Ooka, Tomoaki Matsumura, Tomoo Nakagawa, Makoto Arai, Tatsuro Katsuno, Yoshihiro Fukuda, Yoshio Kitsukawa, Naoya Kato
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract To gain a better understanding of the effects of biologics, we evaluated clinical outcomes in patients with moderate to severe exacerbations of ulcerative colitis (UC). This retrospective, multicenter study retrieved the entire clinical cour
Externí odkaz:
https://doaj.org/article/e3499d5d45394bd896a8cfce785283f1
Autor:
Takayuki Kondo, Kisako Fujiwara, Miyuki Nakagawa, Hidemi Unozawa, Terunao Iwanaga, Takafumi Sakuma, Naoto Fujita, Keisuke Koroki, Hiroaki Kanzaki, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Tetsuhiro Chiba, Makoto Arai, Jun Kato, Naoya Kato
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract The screening of gastroesophageal varices (GEV) is critical in hepatocellular carcinoma (HCC) management. Contrast-enhanced computed tomography (CECT) is often performed in patients with HCC. Therefore, this study aimed to examine the use of
Externí odkaz:
https://doaj.org/article/195628a7649a45c4815c5e21e0540138
Publikováno v:
BMJ Open Gastroenterology, Vol 10, Iss 1 (2023)
Objective The documented variation in gastric cancer (GC) detection among endoscopists has often been dismissed as a coincidental artefact of the low incidence of gastric neoplasms; it is not considered associated with differences in physicians’ pe
Externí odkaz:
https://doaj.org/article/6d21d841e9cb479680be0609d5c65d5f