Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Makoto, UBUKATA"'
Autor:
Albertus Eka Yudistira Sarwono, Shinya Mitsuhashi, Mohammad Hazzaz Bin Kabir, Kengo Shigetomi, Tadashi Okada, Fumina Ohsaka, Satoko Otsuguro, Katsumi Maenaka, Makoto Igarashi, Kentaro Kato, Makoto Ubukata
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 171-178 (2019)
Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential enzyme for the production of guanine nucleotides. Disruption of IMPDH activity has been explored as a therapeutic strategy for numerous purposes, such as for anticancer, immunosuppressi
Externí odkaz:
https://doaj.org/article/5853f45477c74c8dbfdc2be048baba82
Publikováno v:
Molecules, Vol 13, Iss 12, Pp 2998-3006 (2008)
As multiple mechanisms account for polyphenol-induced cytotoxicity, the development of structure-activity relationships (SARs) may facilitate research on cancer therapy. We studied SARs of representatives of 10 polyphenol structural types: (+)-catech
Externí odkaz:
https://doaj.org/article/728d63e4ad4b4b268689bfcea67c24f1
Autor:
Makoto Ubukata, Zornitsa G. Kamenarska, Vassya S. Bankova, Takao Kishimoto, Daniela I. Batovska
Publikováno v:
Molecules, Vol 10, Iss 3, Pp 552-558 (2005)
Natural monoglycerides of cinnamic, ferulic and p-coumaric acids were synthesized in good to high overall yields from isopropylidene glycerol via the Mitsunobu reaction and further deprotection of the corresponding acetonides with Amberlyst 15. The m
Externí odkaz:
https://doaj.org/article/0ee90cf49cfa4bbd8af14afa13ab955b
Publikováno v:
The Journal of Antibiotics. 72:934-942
We have found cyclophane-type adenosine derivatives having p-quinone amide moieties (1 and 2) as weak inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) from the Hokkaido University Chemical Library via the lucifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404d8923a6938f87c6a4d85f9dfdef74
https://doi.org/10.1038/s41429-019-0199-3
https://doi.org/10.1038/s41429-019-0199-3
Publikováno v:
Bioscience, biotechnology, and biochemistry. 85(2)
Hinokitiol has a broad antibacterial activity against bacteria and fungi. While its biosynthetic pathway has been intensively studied, its dynamics in natural environments, such as biodegradation pathway, remain unclear. In this study, the authors re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b710c74e7ad5736ef59aa4bff8ac5dd2
https://pubmed.ncbi.nlm.nih.gov/33590006
https://pubmed.ncbi.nlm.nih.gov/33590006
Publikováno v:
HETEROCYCLES. 104:140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a301bda8357ab1b7dc6ceee929a22a51
https://doi.org/10.3987/com-21-14562
https://doi.org/10.3987/com-21-14562
Publikováno v:
Bioorganic & Medicinal Chemistry / Bioorganic and Medicinal Chemistry. 26(18):5159-5168
(+)-Epogymnolactam (1) was discovered as a novel autophagy inducer from a culture of Gymnopus sp. in our laboratory. To determine structure-activity relationships among (+)-epogymnolactam analogues comparing with cerulenin (2), we synthesized 5 analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::091f76d63244e40ea6628fbf4b5790e8
http://hdl.handle.net/2115/79390
http://hdl.handle.net/2115/79390
Autor:
Makoto Ubukata
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 82:1063-1072
In this review article, I will outline my way of thinking about biologically active small molecules. The structure of liposidomycin B from Streptomyces species resulted in my initial sense that a structure tells its function. A biologically active sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6295d2702837c1c790c6bc9175dd24
https://doi.org/10.1080/09168451.2018.1451740
https://doi.org/10.1080/09168451.2018.1451740
Publikováno v:
Wood Science and Technology. 52:873-886
Advanced glycation end-products (AGEs) are one of the pivotal factors that cause a variety of diabetes complications. To explore a new class of natural resources that can prevent AGEs formation, the inhibitory activities of tree bark extracts against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f03a886c348668140364f9a76c43e67c
https://doi.org/10.1007/s00226-018-1002-5
https://doi.org/10.1007/s00226-018-1002-5
Publikováno v:
KAGAKU TO SEIBUTSU. 57:143-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a70e973913cda44cce089278dd50f60
https://doi.org/10.1271/kagakutoseibutsu.57.143
https://doi.org/10.1271/kagakutoseibutsu.57.143