Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Makoto, Shigeto"'
Publikováno v:
Journal of Pharmacological Sciences, Vol 108, Iss 3, Pp 274-279 (2008)
Glucagon-like peptide-1 (GLP-1) induces pancreatic insulin secretion via the cAMP-dependent protein kinase (PKA) pathway. However, the GLP-1 concentration used in the previous in vitro experiments was far from the in vivo concentrations. Alteration o
Externí odkaz:
https://doaj.org/article/dcdf64e309bb4d1fb126e7607acb3b55
Autor:
Makoto, Shigeto 1, Masashi, Katsura 2, Masafumi, Matsuda 1, Seitaro, Ohkuma 2, Kohei, Kaku 1, *
Publikováno v:
In Journal of Pharmacological Sciences 2006 101(4):293-302
Autor:
Reshma, Ramracheya, Caroline, Chapman, Margarita, Chibalina, Haiqiang, Dou, Caroline, Miranda, Alejandro, González, Yusuke, Moritoh, Makoto, Shigeto, Quan, Zhang, Matthias, Braun, Anne, Clark, Paul R, Johnson, Patrik, Rorsman, Linford J B, Briant
Publikováno v:
Physiological Reports
Glucagon is the body's main hyperglycemic hormone, and its secretion is dysregulated in type 2 diabetes mellitus (T2DM). The incretin hormone glucagon‐like peptide‐1 (GLP‐1) is released from the gut and is used in T2DM therapy. Uniquely, it bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad598c1fdf414635b2531a9ebdd6a39c
https://pubmed.ncbi.nlm.nih.gov/30187652
https://pubmed.ncbi.nlm.nih.gov/30187652
Autor:
Makoto Shigeto, Manuela Zaccolo, Reshma Ramracheya, Antony Galione, William Sones, Thomas Reinbothe, Benoit Hastoy, Rudi Vennekens, Elisa Vergari, Cathryn Weston, Graham Ladds, Viacheslav O. Nikolaev, Chae Young Cha, Masashi Katsura, Nils J.G. Rorsman, Andrei I. Tarasov, Patrik Rorsman, Paul Johnson, Julia Gorelik, Koenraad Philippaert, Margarita V. Chibalina, Albert Salehi, Kohei Kaku
Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); however, it is not clear whether GLP-1 directly drives insulin secretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce9c8d589f091227aa5ae7d0286bf35
https://ora.ox.ac.uk/objects/uuid:bf20aef5-debd-4768-9a1e-76c25351ea79
https://ora.ox.ac.uk/objects/uuid:bf20aef5-debd-4768-9a1e-76c25351ea79
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 95(4)
Glucagon-like peptide-1 (GLP-1) is an endogenous glucose-lowering hormone and GLP-1 receptor agonists are currently being used as antidiabetic drugs clinically. The canonical signalling pathway (including cAMP, Epac2, protein kinase A (PKA) and KATP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086655365aa1afb31da2affc412e6a82
https://pubmed.ncbi.nlm.nih.gov/28097390
https://pubmed.ncbi.nlm.nih.gov/28097390
Autor:
Stefan Amisten, Caroline E. Ward, Paul Johnson, Quan Zhang, Matthias Braun, Patrik Rorsman, Jonathan N. Walker, Makoto Shigeto, Reshma Ramracheya
Publikováno v:
Diabetes
OBJECTIVE To document the properties of the voltage-gated ion channels in human pancreatic α-cells and their role in glucagon release. RESEARCH DESIGN AND METHODS Glucagon release was measured from intact islets. [Ca2+]i was recorded in cells showin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ee9ec8f8fd5bf825041d685eb5a3e8
https://doi.org/10.2337/db09-1505
https://doi.org/10.2337/db09-1505
Publikováno v:
Journal of Neurochemistry. 81:130-141
We investigated a role of nitric oxide (NO) on ionomycin-evoked [3H]GABA release using mouse cerebral cortical neurons. Ionomycin dose-dependently released [3H]GABA up to 1 µm. The extent of the release by 0.1 µm ionomycin was in a range similar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d063d170cb4152ebaffdbf7332cf221f
https://doi.org/10.1046/j.1471-4159.2002.00810.x
https://doi.org/10.1046/j.1471-4159.2002.00810.x
Autor:
Sofia A Andersson, Makoto Shigeto, Patrik Rorsman, Matthias Braun, Leif Groop, Paul Johnson, Enming Zhang, Erik Renström, Amy Barrett, Peter Almgren, Yunzhao Tang, Annika S. Axelsson, Taman Mahdi, Anders Rosengren, Anna Jonsson, Claes Ladenvall, Lena Eliasson, Mary E. Travers, Valeriya Lyssenko, Albert Salehi, Jonathan N. Walker, Morten Gram Pedersen, Mark I. McCarthy, Anna Edlund, Reshma Ramracheya, Anna L. Gloyn
Publikováno v:
Diabetes
The majority of genetic risk variants for type 2 diabetes (T2D) affect insulin secretion, but the mechanisms through which they influence pancreatic islet function remain largely unknown. We functionally characterized human islets to determine secret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0222dc0eb4290c282a4cbf59f057be8
http://hdl.handle.net/11577/2523707
http://hdl.handle.net/11577/2523707
Autor:
Fumiko Kawasaki, Shinji Kamei, Mitsuru Hashiramoto, Fuminori Tatsumi, Makoto Shigeto, Masashi Shimoda, Kazuhito Tawaramoto, Sumiko Hamamoto, Michihiro Matsuki, Yukiko Kanda, Kohei Kaku
Publikováno v:
Internal medicine (Tokyo, Japan). 48(17)
A 29-year-old woman was diagnosed as having type 1 diabetes mellitus and received insulin aspart and NPH insulin (NovolinN). On day 22, she had leg edema and right abdominal pain. The serum hepatobiliary enzyme levels were markedly elevated. Computed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a455cebf285e4137bf1d75c16ab4e5
https://pubmed.ncbi.nlm.nih.gov/19721301
https://pubmed.ncbi.nlm.nih.gov/19721301
Autor:
Michihiro Matsuki, Kazuhito Tawaramoto, Shinji Kamei, Yukiko Kanda, Makoto Shigeto, Katsura Nakayama, Mieko Saito, Fumiko Kawasaki, Masafumi Matsuda, Masaaki Eto, Hayami Nitta, Kohei Kaku, Kenji Kohara
Publikováno v:
Diabetes care. 27(6)
OBJECTIVE—The aim of this study was to investigate the effect of apolipoprotein (apo)E4 allele on plasma LDL cholesterol response to calorie-restricted diet therapy in type 2 diabetic patients. RESEARCH DESIGN AND METHODS—Twenty-four diabetic pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600b03ac5dc9a72a3c477d6d941de4fe
https://pubmed.ncbi.nlm.nih.gov/15161775
https://pubmed.ncbi.nlm.nih.gov/15161775