Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Makoto, Kamei"'
Autor:
Marcelo Cossenza, Roberto Paes-de-Carvalho, Makoto Kamei, Christopher G. Proud, Jianling Xie, Kirk B. Jensen, Luis F. H. Gladulich
Publikováno v:
Journal of Neurochemistry. 157:1086-1101
The regulation of protein synthesis is a vital and finely tuned process in cellular physiology. In neurons, this process is very precisely regulated, as which mRNAs undergo translation is highly dependent on context. One of the most prominent regulat
Autor:
Makoto Kamei, Sandra Isenmann, Christopher G. Proud, Marten F. Snel, John J. Hopwood, Anthony O. Fedele, Paul J. Trim
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:1451-1464
Heparan acetyl CoA: α-glucosaminide N-acetyltransferase (HGSNAT) is a lysosomal multi-pass transmembrane protein whose deficiency may lead to an accumulation of heparan sulphate and the neurodegenerative lysosomal storage disorder mucopolysaccharido
Autor:
Makoto Kamei, Roman V. Lenchine, Marina Kochetkova, Jianling Xie, Kaikai Shen, Lee A. Gethings, Christopher G. Proud, Xuemin Wang, Paul J. Trim, Justin W. Kenney, Marten F. Snel, Ying Zhou
Publikováno v:
International Journal of Cancer. 142:1865-1877
Eukaryotic elongation factor 2 kinase (eEF2K) negatively regulates the elongation phase of mRNA translation and hence protein synthesis. Increasing evidence indicates that eEF2K plays an important role in the survival and migration of cancer cells an
Autor:
Stuart P. De Poi, Makoto Kamei, Ming Hong Shen, Roman V. Lenchine, Shuye Tian, Andrew C.W. Zannettino, Xuemin Wang, Sally Martin, Christopher G. Proud, Swati Irani, Ashley T. Jones, Derick Wong, Lisa M. Butler, Marten F. Snel, Kirk B. Jensen, Jianling Xie, James E. Merrett, Stephen Fitter, Andrew R. Tee, Paul J. Trim, Kaikai Shen, Jian Yang, Mengyuan Yu
Publikováno v:
Cellular and molecular life sciences : CMLS. 78(1)
eIF4E plays key roles in protein synthesis and tumorigenesis. It is phosphorylated by the kinases MNK1 and MNK2. Binding of MNKs to eIF4G enhances their ability to phosphorylate eIF4E. Here, we show that mTORC1, a key regulator of mRNA translation an
Autor:
Makoto Kamei, Brant M. Weinstein, Matthew R. Swift, Kameha Bell, Van N. Pham, Kenna M. Shaw, Brigid D. Lo, Mayumi F Miller, Daniel Castranova, Paul J. Paukstelis, Andrew E. Davis, Jesús Torres-Vázquez
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36:655-662
Objective— Understanding the mechanisms regulating normal and pathological angiogenesis is of great scientific and clinical interest. In this report, we show that mutations in 2 different aminoacyl-transfer RNA synthetases, threonyl tRNA synthetase
Autor:
Timothy J. Sargeant, Peter C. Blumbergs, Makoto Kamei, Julian M. Carosi, Jim Manavis, Sofia Hassiotis, Kathryn J. Hattersley
Publikováno v:
The European journal of neuroscience. 47(9)
Lysosomal vesicles around neuritic plaques are thought to drive Alzheimer's disease by providing ideal microenvironments for generation of amyloid-β. Although lysosomal vesicles are present at every amyloid plaque in mouse models of Alzheimer's dise
Autor:
Jianling, Xie, Kaikai, Shen, Roman V, Lenchine, Lee A, Gethings, Paul J, Trim, Marten F, Snel, Ying, Zhou, Justin W, Kenney, Makoto, Kamei, Marina, Kochetkova, Xuemin, Wang, Christopher G, Proud
Publikováno v:
International journal of cancer. 142(9)
Eukaryotic elongation factor 2 kinase (eEF2K) negatively regulates the elongation phase of mRNA translation and hence protein synthesis. Increasing evidence indicates that eEF2K plays an important role in the survival and migration of cancer cells an
Autor:
Hyun Min Jung, Daniel Castranova, Aniket V. Gore, Makoto Kamei, Brant M. Weinstein, Sumio Isogai
Blood vessels supply tissues and organs with oxygen, nutrients, cellular, and humoral factors, while lymphatic vessels regulate tissue fluid homeostasis, immune trafficking, and dietary fat absorption. Understanding the mechanisms of vascular morphog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d802d76037c7afb5e78b6307e59acb00
https://doi.org/10.1016/bs.mcb.2016.03.023
https://doi.org/10.1016/bs.mcb.2016.03.023
Autor:
J. Silvio Gutkind, Amber N. Stratman, Brigid D. Lo, Brant M. Weinstein, Constantinos M. Mikelis, Kameha R. Kidd, Makoto Kamei, Weijun Pan, George E. Davis, Kenna M. Shaw, Daniel Castranova, Van N. Pham, Jesús Torres-Vázquez
Publikováno v:
Blood. 120:489-498
Understanding the mechanisms that regulate angiogenesis and translating these into effective therapies are of enormous scientific and clinical interests. In this report, we demonstrate the central role of CDP-diacylglycerol synthetase (CDS) in the re
Autor:
Makoto Kamei, Benjamin L. Martin, Daniel Castranova, David W. Raible, Brant M. Weinstein, Evelyn Véliz, Sean Trzaska, Jesús Torres-Vázquez, Van N. Pham, Jorge Carretero-Ortega, Florian Ulrich, Eva Lancaster, Andrew Prendergast, Javier Menéndez, Kameha R. Kidd, Kenna M. Shaw, Carlos Narvaez, Belinda Sun, Brigid D. Lo, Valerie Pershad
Publikováno v:
Development (Cambridge, England)
The cerebral vasculature provides the massive blood supply that the brain needs to grow and survive. By acquiring distinctive cellular and molecular characteristics it becomes the blood-brain barrier (BBB), a selectively permeable and protective inte