Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Makoto, Itakura"'
Autor:
Toshiya Sato, Kanako Oda, Seiko Sakai, Rika Kato, Saori Yamamori, Makoto Itakura, Yoshio Kodera, Masatoyo Nishizawa, Toshikuni Sasaoka, Osamu Onodera, Minesuke Yokoyama
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract TAR DNA-binding protein 43 kDa (TDP-43), a nuclear protein, plays an important role in the molecular pathogenesis of amyotrophic lateral sclerosis (ALS). The long-disordered C-terminal region (CTR) of TDP-43 is known to be aggregation-prone
Externí odkaz:
https://doaj.org/article/419759e22ee04f0e92a2be83c4e71e34
Autor:
Tomohisa Koyama, Kentaro Uchida, Makoto Itakura, Masayuki Miyagi, Ryo Tazawa, Gen Inoue, Kensuke Fukushima, Yoshihisa Ohashi, Ayumi Tsukada, Masashi Takaso
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 7, Pp 3146-3155 (2022)
Expression of the apelin receptor, APJ, in skeletal muscle (SM) is known to decrease with age, but the underlying mechanism remains unclear. Increased tumor necrosis factor (TNF)-α levels are observed in SM with age and are associated with muscle at
Externí odkaz:
https://doaj.org/article/5e8d4c3f56cb408b8970096882664932
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Recent mass spectrometry (MS)-based techniques enable deep proteome coverage with relative quantitative analysis, resulting in increased identification of very weak signals accompanied by increased data size of liquid chromatography (LC)–M
Externí odkaz:
https://doaj.org/article/c4b961b0216b4cf98d42bebbb6cc47ec
Autor:
Yuji Yokozeki, Kentaro Uchida, Ayumu Kawakubo, Mitsufumi Nakawaki, Tadashi Okubo, Masayuki Miyagi, Gen Inoue, Makoto Itakura, Hiroyuki Sekiguchi, Masashi Takaso
Publikováno v:
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans. Increase
Externí odkaz:
https://doaj.org/article/4883f062c4c54a20b245cdeaa73fb551
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 16 (2022)
Dopaminergic neurotransmission via dopamine D1 receptors (D1Rs) is considered to play an important role not only in reward-based learning but also in aversive learning. The contextual and auditory cued fear conditioning tests involve the processing o
Externí odkaz:
https://doaj.org/article/2e306e26c3cb42049245b14a649fc606
Autor:
Kyoko Muneshige, Yuki Inahashi, Makoto Itakura, Masato Iwatsuki, Tomoyasu Hirose, Gen Inoue, Masashi Takaso, Toshiaki Sunazuka, Yoshihisa Ohashi, Etsuro Ohta, Kentaro Uchida
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 5 (2022)
Synovial inflammation plays a central role in joint destruction and pain in osteoarthritis (OA). The NF-κB pathway plays an important role in the inflammatory process and is activated in OA. A previous study reported that a jietacin derivative (JD),
Externí odkaz:
https://doaj.org/article/2b2d62f0d980468bb2cc51e3a24858bc
Autor:
Shigekazu Tabata, Marijo Jevtic, Nobutaka Kurashige, Hirokazu Fuchida, Munetsugu Kido, Kazushi Tani, Naoki Zenmyo, Shohei Uchinomiya, Harumi Harada, Makoto Itakura, Itaru Hamachi, Ryuichi Shigemoto, Akio Ojida
Publikováno v:
iScience, Vol 22, Iss , Pp 256-268 (2019)
Summary: Electron microscopy (EM) is a technology that enables visualization of single proteins at a nanometer resolution. However, current protein analysis by EM mainly relies on immunolabeling with gold-particle-conjugated antibodies, which is comp
Externí odkaz:
https://doaj.org/article/f9927222063b4dbb97cc305480dde8fb
Autor:
Shotaro Takano, Kentaro Uchida, Makoto Itakura, Dai Iwase, Jun Aikawa, Gen Inoue, Manabu Mukai, Masayuki Miyagi, Kosuke Murata, Hiroyuki Sekiguchi, Masashi Takaso
Publikováno v:
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Nerve growth factor (NGF) contributes to pain in knee osteoarthritis (KOA) patients. Transforming growth factor-beta (TGF-β) stimulates NGF expression in chondrocytes from KOA patients. However, the correlation between synovial T
Externí odkaz:
https://doaj.org/article/a6a04b83220e458bbd51be8521958f9d
Autor:
Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruíz, Makoto Itakura, Ana Esther Moreno-Martínez, Luis de la Ossa, Elek Molnár, Yugo Fukazawa, Rafael Luján
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Synapse loss occurs early in Alzheimer’s disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA rece
Externí odkaz:
https://doaj.org/article/88985e5042a54c9aba45bb1318adb97c
Autor:
Kohgaku Eguchi, Philipp Velicky, Elena Hollergschwandtner, Makoto Itakura, Yugo Fukazawa, Johann Georg Danzl, Ryuichi Shigemoto
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Acute brain slice preparation is a powerful experimental model for investigating the characteristics of synaptic function in the brain. Although brain tissue is usually cut at ice-cold temperature (CT) to facilitate slicing and avoid neuronal damage,
Externí odkaz:
https://doaj.org/article/c600924fb9664d95874df254deea8e90