Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mako Nakaya"'
Publikováno v:
The Journal of Immunology. 193:422-430
The noncanonical NF-κB pathway induces processing of the NF-κB2 precursor protein p100, and thereby mediates activation of p52-containing NF-κB complexes. This pathway is crucial for B cell maturation and humoral immunity, but its role in regulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0582110e1ef8c809dc2f9a14e0dc89e
https://doi.org/10.4049/jimmunol.1303237
https://doi.org/10.4049/jimmunol.1303237
Autor:
Yichuan Xiao, Xuhong Cheng, Jin Jin, Mako Nakaya, Qiang Zou, Shao Cong Sun, Hongbo Hu, Xiaofei Zhou, George C. Brittain, Mikyoung Chang
Publikováno v:
The Journal of Experimental Medicine
TPL2 is required for Th17-mediated neuroinflammation during EAE by regulating the TAK1 signaling axis downstream of the IL-17R in astrocytes.
Development of autoimmune diseases, such as multiple sclerosis and experimental autoimmune encephalomye
Development of autoimmune diseases, such as multiple sclerosis and experimental autoimmune encephalomye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb84cda676abb3c500b010fc9351eb2d
https://doi.org/10.1084/jem.20132640
https://doi.org/10.1084/jem.20132640
Autor:
Xuhong Cheng, Xin Lin, Marzenna Blonska, Xiaofei Zhou, Shao Cong Sun, Mikyoung Chang, Jae Hoon Chang, Mako Nakaya, Yichuan Xiao
Publikováno v:
Immunity. 40:692-705
SummaryGlutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T cell activation is poorly understood. We have shown that naive T cell activation is coupled with rapid glutamine uptake, which depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40da71a1e84a969ec27bbe1ef567601
https://doi.org/10.1016/j.immuni.2014.04.007
https://doi.org/10.1016/j.immuni.2014.04.007
Publikováno v:
Journal of blood medicine
The nuclear factor-κB (NF-κB) plays a central role in the activation and survival of lymphocytes. NF-κB, therefore, is pivotal for acquired immunity, but the dysregulation of NF-κB signaling leads to inflammatory diseases and lymphomagenesis. Acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2581609863635b62b1080a7eb68a79b
http://europepmc.org/articles/PMC3262331
http://europepmc.org/articles/PMC3262331
Publikováno v:
Journal of Leukocyte Biology. 86:1295-1303
Interleukin 27 has pro- and anti-inflammatory features and is a potent target for therapy of various immune diseases. Cytokine-mediated immunity plays a crucial role in the pathogenesis of various diseases including infection and autoimmune diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c344252e7f790c24ff3dfaf1017cc75
https://doi.org/10.1189/jlb.0609445
https://doi.org/10.1189/jlb.0609445
Autor:
Giichi Takaesu, Daisuke Aki, Kazuko Saeki, Ryusuke Nakagawa, Toranoshin Ayada, Mako Nakaya, Akihiko Yoshimura, Toshikatsu Hanada, Takashi Kobayashi, Satoru Fukuyama, Yumiko Matsumura
Publikováno v:
The Journal of Immunology. 182:5929-5937
The membrane microdomains known as lipid rafts have been shown to act as platforms for the initiation of various receptor signals. Through proteomic analysis, we have identified a novel protein termed Raftlin (raft-linking protein) as a major protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b4745ddbedb9c17740131ca120f7505
https://doi.org/10.4049/jimmunol.0802672
https://doi.org/10.4049/jimmunol.0802672
Autor:
Yu Wakabayashi, Kenji Ichiyama, Takashi Kobayashi, Kazuko Saeki, Hideyuki Yoshida, Takatoshi Chinen, Giichi Takaesu, Mako Nakaya, Akihiko Yoshimura, Shohei Hori
Publikováno v:
Journal of Biological Chemistry. 283:17003-17008
The cytokine, transforming growth factor-beta1 (TGF-beta1), converts naive T cells into regulatory T cells that prevent autoimmunity. However, in the presence of interleukin (IL)-6, TGF-beta1 has also been found to promote differentiation into IL-17-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478174b2e91c4dc844f0e09e40255c77
https://doi.org/10.1074/jbc.m801286200
https://doi.org/10.1074/jbc.m801286200
Autor:
Giichi Takaesu, Takashi Kobayashi, Satoko Watanabe, Ryoko Yoshida, Takehiro Torisu, Fuyuki Okamoto, Akihiko Yoshimura, Masayuki Hashimoto, Hideyuki Yoshida, Mako Nakaya, Hideo Yasukawa, Kumiko Torisu, Toshikatsu Hanada, Takatoshi Chinen
Publikováno v:
Hepatology. 47:1644-1654
Acute liver failure is associated with significant mortality. However, the underlying pathophysiological mechanism is not yet fully understood. Suppressor of cytokine signaling-1 (SOCS1), which is a negative-feedback molecule for cytokine signaling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546f4d0a58a531c3f73dcdbb3fe071aa
https://doi.org/10.1002/hep.22214
https://doi.org/10.1002/hep.22214
Autor:
Tomasz Zal, Jiayi Yu, Mako Nakaya, Stephanie Dorta-Estremera, Shao Cong Sun, Yichuan Xiao, Xiaofei Zhou, Anna Zal, Jae Hoon Chang, J. William Lindsey, Wei Cao, Mikyoung Chang
Publikováno v:
Nature Communications
Development of an immune or autoimmune response involves T-cell activation in lymphoid organs and subsequent migration to peripheral tissues. Here we show that T-cell-specific ablation of the kinase TBK1 promotes T-cell activation but causes retentio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75418e01d8850f2cd8478a627afde93f
https://doi.org/10.1038/ncomms7074
https://doi.org/10.1038/ncomms7074
Autor:
Mako Nakaya, Anna D'Angelillo, Maria Romano, Yichuan Xiao, Mariorosario Masullo, Simona Romano, Xixi Feng, Mikyoung Chang, Felix Hausch, Jin Jin, Shao Cong Sun
Publikováno v:
Nucleic Acids Research
NUCLEIC ACIDS RESEARCH
NUCLEIC ACIDS RESEARCH
Melanoma is the most aggressive skin cancer; its prognosis, particularly in advanced stages, is disappointing largely due to the resistance to conventional anticancer treatments and high metastatic potential. NF-kappa B constitutive activation is a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfff625883f84a3fc61c046b898a404
http://hdl.handle.net/11367/39425
http://hdl.handle.net/11367/39425
