Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Makiya Nishikawa"'
Autor:
Daisuke Sasaki, Hinako Suzuki, Kosuke Kusamori, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Rice bran a by-product of the rice milling process is currently underutilized. Recent studies have shown that plant-derived nanoparticles (pdNPs) can be mass-produced at a low cost and exhibit biological and therapeutic activities
Externí odkaz:
https://doaj.org/article/9c1cb045dab54284b2a343c35537cc2a
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Mesenchymal stem/stromal cells (MSCs) have been used in clinical trials for various diseases. These have certain notable functions such as homing to inflammation sites, tissue repair, and immune regulation. In many pre-clinical st
Externí odkaz:
https://doaj.org/article/f85166ed1723468d80fce71248e38517
Autor:
Mari Tsujimura, Kosuke Kusamori, Kodai Takamura, Temmei Ito, Takatoshi Kaya, Kazunori Shimizu, Satoshi Konishi, Makiya Nishikawa
Publikováno v:
Biotechnology Reports, Vol 36, Iss , Pp e00766- (2022)
Three-dimensional cell spheroids are superior cell-administration form for cell-based therapy which generally exhibit superior functionality and long-term survival after transplantation. Here, we nondestructively measured the oxygen consumption rate
Externí odkaz:
https://doaj.org/article/0ff7f590958d43b5a5cf389234b0df60
Autor:
Daisuke Sasaki, Kosuke Kusamori, Yukiya Takayama, Shoko Itakura, Hiroaki Todo, Makiya Nishikawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Recent studies showed that plant-derived nanoparticles (NPs) can be easily produced in high yields and have potential applications as therapeutic agents or delivery carriers for bioactive molecules. In this study, we selected corn as it is i
Externí odkaz:
https://doaj.org/article/3ad506f4c34b4dada91c8ee949aefc8f
Autor:
Ryota Suzuki, Kosuke Kusamori, Kodai Takamura, Yuma Miyakawa, Shu Obana, Shoko Itakura, Makiya Nishikawa
Publikováno v:
Applied Sciences, Vol 13, Iss 11, p 6676 (2023)
Cell-based therapy is an excellent therapeutic modality that involves cell transplantation into patients; however, given that most transplanted cells die immediately post-transplantation, the application of this strategy remains limited. Cell encapsu
Externí odkaz:
https://doaj.org/article/44129b77a49a47f3beb047b943b9ab55
Publikováno v:
Molecules, Vol 25, Iss 3, p 728 (2020)
Guanosine- and uridine-rich single-stranded RNA (GU-rich RNA) is an agonist of Toll-like receptor (TLR) 7 and TLR8 and induces strong immune responses. A nanostructured GU-rich RNA/DNA assembly prepared using DNA nanotechnology can be used as an adju
Externí odkaz:
https://doaj.org/article/34bbb8d2361e473f868e01e181a1525a
Publikováno v:
Pharmaceutics, Vol 7, Iss 3, Pp 199-212 (2015)
Short-term expression of transgenes is one of the problems frequently associated with non-viral in vivo gene transfer. To obtain experimental evidence for the design of sustainable transgene expression systems, the contribution of epigenetic modifica
Externí odkaz:
https://doaj.org/article/5ad0dfe1cab84b4d9431db122d12c98f
Autor:
Takafumi Imai, Yuki Takahashi, Makiya Nishikawa, Kana Kato, Masaki Morishita, Takuma Yamashita, Akihiro Matsumoto, Chonlada Charoenviriyakul, Yoshinobu Takakura
Publikováno v:
Journal of Extracellular Vesicles, Vol 4, Iss 0, Pp 1-8 (2015)
Previous studies using B16BL6-derived exosomes labelled with gLuc–lactadherin (gLuc-LA), a fusion protein of Gaussia luciferase (a reporter protein) and lactadherin (an exosome-tropic protein), showed that the exosomes quickly disappeared from the
Externí odkaz:
https://doaj.org/article/bf6f3400a500486286ce2dacb665d833
Autor:
Hidemasa Katsumi, Jun-Ichi Sano, Makiya Nishikawa, Keiko Hanzawa, Toshiyasu Sakane, Akira Yamamoto
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135966 (2015)
To establish a rational molecular design for bisphosphonate (BP)-modified proteins for efficient bone targeting, a pharmacokinetic study was performed using a series of alendronate (ALN), a nitrogen-containing BP, modified proteins with various molec
Externí odkaz:
https://doaj.org/article/27dc9089af4e497a9dfab7b86aa373e6
Autor:
Mitsuru Ando, Yuki Takahashi, Takuma Yamashita, Mai Fujimoto, Makiya Nishikawa, Yoshihiko Watanabe, Yoshinobu Takakura
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Sustained gene delivery of interferon (IFN) γ can be an effective treatment, but our previous study showed high levels of IFNγ-induced adverse events, including the loss of body weight. These unwanted events could be reduced by target-specific deli
Externí odkaz:
https://doaj.org/article/0b375e3eea4f4ffc9ce630d15b41f303