Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Makio Ohtsuki"'
Autor:
Koji Oda, Kosuke Okada, Hirotoshi Utsunomiya, Keiko Taguchi, Kaoru Ishizaki, Nobuharu Goto, Hirokazu Sugimoto, Junichi Shoda, Jonathan M. Maher, Masayuki Yamamoto, Tetsuro Ishii, Yoshimi Inoue, Eiji Warabi, Makio Ohtsuki
Publikováno v:
Biochemical and Biophysical Research Communications. 389:431-436
The transcription factor Nrf2 is a key regulator for hepatic induction of detoxifying enzymes, antioxidative stress genes and Mrp efflux transporters. We aimed to investigate whether Nrf2 activation counteracts liver injury associated with cholestasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacb1f5bf42d4b950352e0beb4b8cece
https://doi.org/10.1016/j.bbrc.2009.08.156
https://doi.org/10.1016/j.bbrc.2009.08.156
Autor:
Makio Ohtsuki, Junichi Shoda, Tetsuro Ishii, Ichinosuke Hyodo, Keiko Osaka, Kaoru Ishizaki, Koichi Takeda, Eiji Warabi, Yoshimi Inoue, Nobuharu Goto, Jonathan M. Maher, Keiko Taguchi, Masayuki Yamamoto, Koji Oda, Hirotoshi Utsunomiya, Kosuke Okada
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 295:G735-G747
The protective action of ursodeoxycholic acid (UDCA) in cholestatic liver diseases may be mediated by choleresis, detoxification, and cytoprotection against oxidative stress. Nrf2, one transcription factor, serves as a cellular stress sensor and is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c354e105145f71a749f99412862ef4
https://doi.org/10.1152/ajpgi.90321.2008
https://doi.org/10.1152/ajpgi.90321.2008
Autor:
Yasuhiro Maeda, Makio Ohtsuki, Ryoji Hirose, Kunio Sugahara, Masatoshi Kiuchi, K Chiba, Y Hoshino, Hirotoshi Kataoka, Kunitomo Adachi, Hirofumi Matsuyuki
Publikováno v:
Transplantation Proceedings. 37:102-106
FTY720, a new class of immunomodulator, induces lymphopenia by sequestration of circulating lymphocytes into secondary lymphoid tissues. FTY720 at 0.1 to 1 mg/kg significantly prolonged the allograft survival in a dose-dependent manner and showed a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3158e44dabcc215dd854911d023bd9
https://doi.org/10.1016/j.transproceed.2004.12.286
https://doi.org/10.1016/j.transproceed.2004.12.286
Autor:
Masahide Nakajima, Yasuhiro Egi, Makio Ohtsuki, Masayoshi Uehata, Nobuharu Goto, Koh-ichi Oshita, Ken-ichi Katayama, Yusaku Amano, K Chiba, Kazutaka Hayashi, Takao Kondo, Hirotoshi Kataoka, Akihiro Fujii
Publikováno v:
Cancer Chemotherapy and Pharmacology. 52:319-324
Rho-associated coiled-coil-forming protein kinase (ROCK) is pivotally involved in invasion by tumor cells and their evolution to metastasis. We have developed a novel inhibitor of ROCK, Wf-536 [(+)-(R)-4-(1-aminoethyl)-N-(4-pyridyl) benzamide monohyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0891033ce8823bcf8370d0e9b3ae274a
https://doi.org/10.1007/s00280-003-0641-9
https://doi.org/10.1007/s00280-003-0641-9
Autor:
Tetsuro Fujita, Masatoshi Kiuchi, Yoshiyuki Aoki, Koji Teshima, Yukio Hoshino, Tadashi Mishina, Kunitomo Yoshitomi Phar Adachi, Masanori Minoguchi, Tokushi Hanano, Masafumi Arita, Toshiyuki Yoshitomi Pharmaceutical Ind.Ltd. Kohara, Makio Ohtsuki, Noriyoshi Nakao, Kenji Chiba, Shigeo Sasaki
Publikováno v:
Journal of Medicinal Chemistry. 43:2946-2961
A series of 2-substituted 2-aminopropane-1,3-diols was synthesized and evaluated for their lymphocyte-decreasing effect and immunosuppressive effect on rat skin allograft. A phenyl ring was introduced into the alkyl chain of the lead compound 3, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6291050667a1f199cc5daaefd8e35eb
https://doi.org/10.1021/jm000173z
https://doi.org/10.1021/jm000173z
Autor:
N. Sato, Hirotoshi Kataoka, K Chiba, Makio Ohtsuki, Y Hoshino, S. Mochizuki, M. Murata, Kunio Sugahara, Kyoko Shimano, K. Oshita
Publikováno v:
Transplantation Proceedings. 37:107-109
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66830fe19f6446cd9865c9d3b7d82f21
https://doi.org/10.1016/j.transproceed.2004.12.287
https://doi.org/10.1016/j.transproceed.2004.12.287
Publikováno v:
Transplantation Proceedings. 31:1224-1226
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b900f02fc91295b7b4489cb9d92d8b
https://doi.org/10.1016/s0041-1345(98)01973-3
https://doi.org/10.1016/s0041-1345(98)01973-3
Autor:
T Kawaguchi, Makio Ohtsuki, Y Hoshino, K Chiba, Y Yanagawa, Kunio Sugahara, Hirotoshi Kataoka
Publikováno v:
Transplantation proceedings. 31(1-2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841a8e9eb2efb296b35343ab3567b76d
https://pubmed.ncbi.nlm.nih.gov/10083548
https://pubmed.ncbi.nlm.nih.gov/10083548
Autor:
Kenji Chiba, Yoshiki Yanagawa, Yumi Masubuchi, Hirotoshi Kataoka, Takafumi Kawaguchi, Makio Ohtsuki, Yukio Hoshino
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(10)
FTY720, given i.v. or orally at 0.03 mg/kg or more, significantly prolonged skin allograft survival in a dose-dependent manner and showed more potent immunosuppressive activity than cyclosporin A (CsA) or tacrolimus (FK506) in MHC-incompatible rat st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedde687698571a284e86de6bc941f22
https://pubmed.ncbi.nlm.nih.gov/9590253
https://pubmed.ncbi.nlm.nih.gov/9590253
Autor:
Kenji Chiba, Hirotoshi Kataoka, Makio Ohtsuki, Kunio Sugahara, Kyoko Shimano, Y Hoshino, M. Murata, K. Oshita
Publikováno v:
Transplantation. 78:623-624
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1664dbe7c49d5e06b4555f2c046dc1ab
https://doi.org/10.1097/00007890-200407271-01679
https://doi.org/10.1097/00007890-200407271-01679