Výsledky vyhledávání - "Makio Kitazawa"

Effects of KMD-3213, a Uroselective α1A-Adrenoceptor Antagonist, on the Tilt-Induced Blood Pressure Response in Normotensive Rats

Autor: Makio Kitazawa, Masachiyo Hora, Ryoichi Yamagishi, Katsuyoshi Akiyama

Publikováno v: Japanese Journal of Pharmacology. 90:131-137

KMD-3213 ((-)-1-(3-hydroxypropyl)-5-((2R)-2-[[2-([2-[(2,2,2-trifluoroethyl)oxy]phenyl]oxy)ethyl]amino]propyl)-2,3-dihydro-1H-indole-7-carboxamide), an alpha(1A)-adrenoceptor antagonist with potency similar to that of tamsulosin, is under development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc62076f02019b90f3d1f413b97c55f
https://doi.org/10.1254/jjp.90.131

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KDR-5169, a new gastrointestinal prokinetic agent, enhances gastric contractile and emptying activities in dogs and rats

Autor: Shigeki Tazawa, Takashi Koizumi, Naoyuki Masuda, Tokio Nakane, Hiroshi Miyata, Makio Kitazawa

Publikováno v: European Journal of Pharmacology. 434:169-176

KDR-5169, 4-amino-5-chloro- N -[1-(3-fluoro-4-methoxybenzyl)piperidin-4-yl]-2-(2-hydroxyethoxy)benzamide hydrochloride dihydrate, is a new prokinetic with a dual action, i.e., stimulation of the 5-HT 4 receptor and antagonism of the dopamine D2 recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb046363b359fe3ae8dc8a18eb9a8ab
https://doi.org/10.1016/s0014-2999(01)01543-6

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Effect of KMD-3213, an alpha1A-adrenoceptor antagonist, on the prostatic urethral pressure and blood pressure in male decerebrate dogs

Autor: Seigi Tsuchida, Osamu Nishizawa, Hiromitsu Noto, Makio Kitazawa, Katsuyoshi Akiyama, Ryoichi Yamagishi, Kimio Sugaya

Publikováno v: International Journal of Urology. 8:177-183

Background: KMD-3213 is an α1A-adrenoceptor-selective antagonist currently being developed for the treatment of urinary outlet obstruction in patients with benign prostatic hyperplasia. In the present study, the uroselectivity of KMD-3213 was evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac94fd48bfefa2cec352e423aa7269b
https://doi.org/10.1046/j.1442-2042.2001.00277.x

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Stereoselective Halogenation in Friedel-Crafts Acylation of 1-Acetylindoline with Chiral 2-(Methanesulfonyloxy)propionyl Chlorides

Autor: Akikazu Kakehi, Suketaka Ito, Masaaki Ban, Makio Kitazawa, Kosuke Okazaki, Motoyasu Ozawa

Publikováno v: Chemical and Pharmaceutical Bulletin. 45:765-768

The Friedel-Crafts acylation of 1-acetylindoline with (S)-2- or (R)-2-(methanesulfonyloxy)propionyl chloride, and aluminum chloride in dichloromethane at room temperature did not afford the expected (S)- or (R)-1-acetyl-5-[2-(methanesulfonyloxy)propi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15889f3ec8cdbfebb0e3852771ec2183
https://doi.org/10.1248/cpb.45.765

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Studies on the Synthesis of Cholecystokinin A Receptor Antagonists. II. Synthesis and Cholecystokinin A Receptor Inhibitory Activities of Sulfur-Containing Amide-Carboxylic Acid Derivatives

Autor: Nakano Yasushi, Yukiyoshi Ajisawa, Makio Kitazawa, Kosuke Okazaki, Michihiro Kobayashi, Atsushi Tsubaki, Masaaki Ban, Sato Kazuaki

Publikováno v: YAKUGAKU ZASSHI. 116:396-410

A number of sulfur-containing amide-carboxylic acid derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activitie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc22d816bef29280e8b466aea6b7e2e
https://doi.org/10.1248/yakushi1947.116.5_396

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Studies on the Synthesis of Cholecystokinin A Receptor Antagonists. I. Synthesis and Cholecystokinin A Receptor Inhibitory Activities of Malonamide Derivatives

Autor: Yukiyoshi Ajisawa, Michihiro Kobayashi, Makio Kitazawa, Masahiko Uchida

Publikováno v: YAKUGAKU ZASSHI. 116:50-58

2-Substituted malonamide derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity. Significant CCK-A receptor inhibitory activities were found in only three compounds (4g-i) which have carboxyl group. In orde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea869a90c22bce5806c2ca3ac9e89801
https://doi.org/10.1248/yakushi1947.116.1_50

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ChemInform Abstract: Stereoselective Halogenation in Friedel-Crafts Acylation of 1- Acetylindoline with Chiral 2-(Methanesulfonyloxy)propionyl Chlorides

Autor: Suketaka Ito, Masaaki Ban, Akikazu Kakehi, Makio Kitazawa, Motoyasu Ozawa, Kosuke Okazaki

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f86d8adf2690b420aad528667585ea9e
https://doi.org/10.1002/chin.199745126

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[Studies on the synthesis of cholecystokinin A receptor antagonists. III. Synthesis and cholecystokinin A receptor inhibitory activities of naphthyl sulfone derivatives]

Autor: Makio Kitazawa, Atsushi Tsubaki, Kosuke Okazaki, Masahiko Uchida, Masaaki Ban, Yukiyoshi Ajisawa, Sato Kazuaki, Nakano Yasushi, Michihiro Kobayashi

Publikováno v: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 116(8)

A number of naphthyl sulfone derivatives were synthesized and tested for cholecystokinin A (CCK-A) receptor inhibitory activity in order to study structure-activity relationships. Significant CCK-A receptor inhibitory activities were found in sulfone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3915d0f06d98af8c4f08d017f72bf2
https://pubmed.ncbi.nlm.nih.gov/8831266

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