Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Makiko Uchida"'
Autor:
Marc Bailly, Carl Mieczkowski, Veronica Juan, Essam Metwally, Daniela Tomazela, Jeanne Baker, Makiko Uchida, Ester Kofman, Fahimeh Raoufi, Soha Motlagh, Yao Yu, Jihea Park, Smita Raghava, John Welsh, Michael Rauscher, Gopalan Raghunathan, Mark Hsieh, Yi-Ling Chen, Hang Thu Nguyen, Nhung Nguyen, Dan Cipriano, Laurence Fayadat-Dilman
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Monoclonal antibodies play an increasingly important role for the development of new drugs across multiple therapy areas. The term ‘developability’ encompasses the feasibility of molecules to successfully progress from discovery to development vi
Externí odkaz:
https://doaj.org/article/adb0a7cc163a47868054a9dee9dd053c
Autor:
Carl Mieczkowski, Alan Cheng, Thierry Fischmann, Mark Hsieh, Jeanne Baker, Makiko Uchida, Gopalan Raghunathan, Corey Strickland, Laurence Fayadat-Dilman
Publikováno v:
Antibodies, Vol 10, Iss 1, p 8 (2021)
Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable. For a strongly self-associating humanized mAb variant, resulting in unacceptable vis
Externí odkaz:
https://doaj.org/article/73b2cc3971324cedaf93982b4037c83f
Autor:
Sayaka Yoshiba, Masayasu Iwase, Sayaka Kurihara, Makiko Uchida, Yuji Kurihara, Hitoshi Watanabe, Satoru Shintani
Publikováno v:
Oncology Reports. 49
Autor:
Laurence Fayadat-Dilman, Thierry O. Fischmann, Jeanne Baker, Corey Strickland, Alan C. Cheng, Mark Hsieh, Makiko Uchida, Gopalan Raghunathan, Carl Mieczkowski
Publikováno v:
Antibodies
Volume 10
Issue 1
Antibodies, Vol 10, Iss 8, p 8 (2021)
Volume 10
Issue 1
Antibodies, Vol 10, Iss 8, p 8 (2021)
Reversible antibody self-association, while having major developability and therapeutic implications, is not fully understood or readily predictable and correctable. For a strongly self-associating humanized mAb variant, resulting in unacceptable vis
Publikováno v:
International Journal of Biological Macromolecules. 62:487-493
This research focused on evaluation and application of two methods in studying weak protein-protein interactions, i.e. diffusion interaction parameter (KD) and second virial coefficient (B22), both of which are first-order coefficients of protein int
Autor:
Makiko Uchida, Masayasu Iwase, Gen Kondo, Masao Nagumo, Hitoshi Watanabe, Masaru Ohashi, Sayaka Takaoka
Publikováno v:
Oral Oncology. 42:745-752
In general, oral squamous cell carcinoma (OSCC) cells are relatively resistant to Fas-mediated apoptosis during in vitro culture. Here, we studied the role of survival/apoptosis associated phosphatidylinositol 3-kinase (PI 3-K)/Akt in this process. W
Autor:
Makiko Uchida, Sayaka Takaoka, Masao Nagumo, Hitoshi Watanabe, Gen Kondo, Masaru Ohashi, Masayasu Iwase
Publikováno v:
International Immunopharmacology. 6:334-341
Inflammatory stimuli, such as cytokines, can induce cyclooxygenase-2 (COX-2) expression in neutrophils. Selective, anti-inflammatory COX-2 inhibitors have been developed for patients with acute inflammatory diseases. Recent work has shown that select
Autor:
Felix Naef, Makiko Uchida, Ignacio Munoz Sanjuan, Noboru Sato, Ali H. Brivanlou, Michael Heke
Publikováno v:
Developmental Biology. 260(2):404-413
The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the first global transcriptional profile of the state of “stemness” in human embryonic stem cells (HESCs). We have identified a set of 918 genes enriched in undi
Publikováno v:
Journal of the Neurological Sciences. 167:137-141
We report a case of a woman with primary progressive aphasia (PPA) who presented with conduction aphasia. A 60-year-old, right-handed, Japanese female suffering from progressive aphasia had difficulty in repeating words and phrases. She displayed pho
Autor:
Shoichi Tanaka, Kenji Hachisuka, Koichiro Dozono, Masayuki Kobayashi, Makiko Uchida, Syousaku Noda, Hajime Ogata
Publikováno v:
The Japanese Journal of Rehabilitation Medicine. 33:326-329
We report a 19-year-old man suffering from acute poliomyelitis induced by the attenuated strain of type 3 polio virus. As he had severe muscular weakness in the right lower limb and slight weakness in the left lower limb, we prescribed the following