Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Makiko Nagai"'
Autor:
Gen Sobue, Hirofumi Maruyama, Keiko Imamura, Yuishin Izumi, Satoshi Morita, Naohiro Egawa, Takashi Ayaki, Makiko Nagai, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ritsuko Hanajima, Koji Fujita, Naoto Takahashi, Akiko Morinaga, Ryosuke Takahashi, Haruhisa Inoue, Naoki Atsuta, Osamu Kano, Takehisa Hirayama, Takao Kiriyama, Hiroshi Kataoka, Takahiko Tokuda, Kazuma Sugie, Takenobu Murakami, Hitoki Nanaura, Masahiro Nakamori, Shotaro Haji, Harutsugu Tatebe, Riko Tabuchi, Motoki Oe, Mihoko Kobayashi, Kasia Lobello
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Introduction Amyotrophic lateral sclerosis (ALS) is a progressive, severe neurodegenerative disease caused by motor neuron death. Development of a medicine for ALS is urgently needed, and induced pluripotent cell-based drug repurposing identified a S
Externí odkaz:
https://doaj.org/article/63d3495d00e24d60a205cd5377da8720
Autor:
Etsuro Ohta, Takefumi Sone, Hideki Ukai, Tomoko Hisamatsu, Tokiko Kitagawa, Mitsuru Ishikawa, Makiko Nagai, Hiroki R. Ueda, Fumiya Obata, Hideyuki Okano
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102073- (2020)
Leucine-rich repeat kinase 2 (LRRK2) is the causal gene of the autosomal dominant hereditary form of Parkinson’s disease (PD), PARK8. We have previously reported that induced pluripotent stem cells (iPSCs) from a PARK8 patient with I2020T LRRK2 mut
Externí odkaz:
https://doaj.org/article/e73f21c0818b474ab9a899da62495144
Autor:
Hisashi Narai, Yasuhiro Manabe, Makiko Nagai, Isao Nagano, Yasuyuki Ohta, Tetsuro Murakami, Yasushi Takehisa, Tatsushi Kamiya, Koji Abe
Publikováno v:
Neurology International, Vol 1, Iss 1, Pp e16-e16 (2009)
The transgenic animals with mutant copper/zinc superoxide dismutase (SOD1) DNA develop paralytic motor neuron disease resembling human amyotrophic lateral sclerosis (ALS) patients and are commonly used as models for ALS. In the transgenic (Tg) mice w
Externí odkaz:
https://doaj.org/article/8ed210a4e1e740968c5300252911c1c9
Autor:
Kaori Adachi, Eiji Nanba, Kinuko Suzuki, Shoji Tsuji, Makiko Nagai, Kazutoshi Nishiyama, Naomi Kanazawa, Jun Mitsui, Shigeo Murayama, Masaaki Ichinoe, Akiko Uchino, Nobuyuki Yanagisawa, Hiroyuki Ishiura
Publikováno v:
Neuropathology. 40:379-388
GM1 gangliosidosis is a storage disorder with autosomal recessive inheritance caused by deficiency of β-galactosidase (GLB1), which is a lysosomal hydrolase, due to mutations in GLB1. We describe here an autopsy case of GM1 gangliosidosis in a femal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af040a26bba8e5e5c691c658736dd2e3
https://doi.org/10.1111/neup.12651
https://doi.org/10.1111/neup.12651
Autor:
Satoshi Yamashita, Takashi Kurashige, Tokunori Ikeda, T. Doki, Y. Matsuo, Hirofumi Maruyama, Makiko Nagai, X. Zhang, Yohei Misumi, Yukio Ando, N. Tawara, Kentaro Hara, Z. Zhang
Publikováno v:
The Journal of Pathology. 249:182-192
Mutations in the Matrin 3 (MATR3) gene have been identified as a cause of amyotrophic lateral sclerosis (ALS) or vocal cord and pharyngeal weakness with distal myopathy (VCPDM). This study investigated the mechanism by which mutant MATR3 causes multi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c984f2cd1e8f63554ce5bbe43c5f55
https://doi.org/10.1002/path.5289
https://doi.org/10.1002/path.5289
Autor:
Shin Kwak, Akira Tamaoka, Hidenao Sasaki, Makiko Nagai, Masashi Aoki, Hitoshi Aizawa, Koji Oba, Gen Sobue, Tomoko Saito, Takuya Kawahara, Yoshihiko Okubo, Hiroyuki Ishiura, Haruhisa Kato, Hitoshi Warita, Tatsushi Toda, Makoto Urushitani, Masahisa Katsuno, Makiko Naito, Koji Abe, Hidehiro Mizusawa, Yutaka Matsuyama, Naoki Atsuta, Yasushi Maeda, Akihiro Kawata, Kazuhiro Ishii, Takashi Kanda, Tomohiro Haga, Kiyotaka Nakamagoe, Ichiro Yabe, Kazutoshi Nishiyama, Ikuko Takahashi-Iwata
Publikováno v:
Journal of Neurology
Objective To evaluate the efficacy and safety of perampanel in patients with sporadic amyotrophic lateral sclerosis (SALS). Methods This randomized, double-blind, placebo-controlled, multicenter, phase 2 clinical study was conducted at 12 sites. Pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f10f12140f9aab7c50099154151ed4b
https://pubmed.ncbi.nlm.nih.gov/34191081
https://pubmed.ncbi.nlm.nih.gov/34191081
Autor:
Jens Christian Schwamborn, Kahori Shiba-Fukushima, Silvia Bolognin, Taku Hatano, Masayoshi Kano, Yuzuru Imai, Genko Oyama, Kazuko Hasegawa, Wado Akamatsu, Kazutoshi Nishiyama, Masashi Takanashi, Asako Yoritaka, Tsuyoshi Inoshita, Makiko Nagai, Nobutaka Hattori, Kei-Ichi Ishikawa
Publikováno v:
NPJ Parkinson's Disease
npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-9 (2020)
npj Parkinson's Disease, Vol 6, Iss 1, Pp 1-9 (2020)
Parkin (encoded by PRKN) is a ubiquitin ligase that plays an important role in cellular mitochondrial quality control. Mutations in PRKN cause selective dopaminergic cell loss in the substantia nigra and are presumed to induce a decrease in mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6231ba0a46c5385a1bd8da8bd6003421
https://pubmed.ncbi.nlm.nih.gov/33298969
https://pubmed.ncbi.nlm.nih.gov/33298969
Autor:
Haruhisa Kato, Yoshihiko Okubo, Koji Oba, Hidehiro Mizusawa, Koji Abe, Gen Sobue, Makoto Urushitani, Yutaka Matsuyama, Makiko Nagai, Akira Tamaoka, Hitoshi Warita, Hiroyuki Ishiura, Masahisa Katsuno, Tomoko Saito, Hidenao Sasaki, Masashi Aoki, Hitoshi Aizawa, Ikuko Iwata, Makiko Naito, Tatsushi Toda, Naoki Atsuta, Kiyotaka Nakamagoe, Yasushi Maeda, Kazutoshi Nishiyama, Ichiro Yabe, Tomohiro Haga, Akihiro Kawata, Kazuhiro Ishii, Takashi Kanda, Shin Kwak, Takuya Kawahara
Publikováno v:
SSRN Electronic Journal.
Background: Perampanel, a non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, arrested disease progression in a sporadic ALS (SALS) mouse model, suggesting its potential use in humans. Methods: This mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3192ca443996b19c867635901a18baa2
https://doi.org/10.2139/ssrn.3688244
https://doi.org/10.2139/ssrn.3688244
Autor:
Haruhiko Banno, Akiko Morinaga, Akira Shimizu, Naoto Takahashi, Haruhisa Inoue, Makiko Nagai, Yuishin Izumi, Keiko Imamura, Satoshi Morita, Ryuji Uozumi, Takafumi Ikeda, Ritsuko Hanajima, Takashi Ayaki, Tomoko Hirohashi, Naohiro Egawa, Koji Fujita, Yosuke Fujii, Ryosuke Takahashi, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ryosuke Oki
Publikováno v:
BMJ Open
IntroductionAmyotrophic lateral sclerosis (ALS) is a progressive and severe neurodegenerative disease caused by motor neuron death. There have as yet been no fundamental curative medicines, and the development of a medicine for ALS is urgently requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12970d46a92268fcbc6a6e3cfec0810
https://pubmed.ncbi.nlm.nih.gov/31796494
https://pubmed.ncbi.nlm.nih.gov/31796494
Autor:
Satoshi Morita, Makiko Nagai, Ryosuke Takahashi, Naohiro Egawa, Keiko Imamura, Ritsuko Hanajima, Haruhisa Inoue, Yosuke Fujii, Takashi Ayaki, Yuishin Izumi, Tomoko Hirohashi, Akiko Morinaga, Koji Fujita, Kazutoshi Nishiyama, Yasuhiro Watanabe, Ryosuke Oki, Ryuji Uozumi
Publikováno v:
Journal of the Neurological Sciences. 429:119418
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd09a369141f7d27269c11e5a5ec72c6
https://doi.org/10.1016/j.jns.2021.119418
https://doi.org/10.1016/j.jns.2021.119418