Výsledky vyhledávání - "Makiko NAKAHARA"

Akademický článek

U-Net Convolutional Neural Network for Real-Time Prediction of the Number of Cultured Corneal Endothelial Cells for Cellular Therapy

Autor: Naoki Okumura, Takeru Nishikawa, Chiaki Imafuku, Yuki Matsuoka, Yuna Miyawaki, Shinichi Kadowaki, Makiko Nakahara, Yasushi Matsuoka, Noriko Koizumi

Publikováno v: Bioengineering, Vol 11, Iss 1, p 71 (2024)

Corneal endothelial decompensation is treated by the corneal transplantation of donor corneas, but donor shortages and other problems associated with corneal transplantation have prompted investigations into tissue engineering therapies. For clinical

Externí odkaz: https://doaj.org/article/7f3db3b13ca84dbf92e216715dcd8412

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Akademický článek

Forskolin rapidly enhances neuron‐like morphological change of directly induced‐neuronal cells from neurofibromatosis type 1 patients

Autor: Noriaki Sagata, Shin‐ichi Kano, Masahiro Ohgidani, Shogo Inamine, Yasunari Sakai, Hiroki Kato, Keiji Masuda, Takeshi Nakahara, Makiko Nakahara‐Kido, Shouichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba, Takahiro A. Kato

Publikováno v: Neuropsychopharmacology Reports, Vol 40, Iss 4, Pp 396-400 (2020)

Abstract Aim Neurofibromatosis type 1 (NF1) is a multifaceted disease, and frequently comorbid with neurodevelopmental disorders such as autism spectrum disorder (ASD) and learning disorder. Dysfunction of adenylyl cyclase (AC) is one of the candidat

Externí odkaz: https://doaj.org/article/ee59a769ea2f4ccfbc0fe75e7c8893c3

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Akademický článek

Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy

Autor: Naoki Okumura, Keisuke Hashimoto, Miu Kitahara, Hirokazu Okuda, Emi Ueda, Kyoko Watanabe, Makiko Nakahara, Takahiko Sato, Shigeru Kinoshita, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Noriko Koizumi

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract Fuchs endothelial corneal dystrophy (FECD) is a slowly progressive bilateral disease of corneal endothelium in which accumulation of extracellular matrix (ECM) and loss of corneal endothelial cells (CECs) are phenotypic features. The corneal

Externí odkaz: https://doaj.org/article/2bcf614c5cd14afdb25ec7f9a4fe5f01

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Akademický článek

Generation and Feasibility Assessment of a New Vehicle for Cell-Based Therapy for Treating Corneal Endothelial Dysfunction.

Autor: Naoki Okumura, Kazuya Kakutani, Ryota Inoue, Daiki Matsumoto, Tomoki Shimada, Makiko Nakahara, Yumiko Kiyanagi, Takehiro Itoh, Noriko Koizumi

Publikováno v: PLoS ONE, Vol 11, Iss 6, p e0158427 (2016)

The corneal endothelium maintains corneal transparency by its pump and barrier functions; consequently, its decompensation due to any pathological reason causes severe vision loss due to corneal haziness. Corneal transplantation is the only therapeut

Externí odkaz: https://doaj.org/article/145ffc2c64e14ed98fb3bb8db8b49b0a

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Akademický článek

Cultivation of corneal endothelial cells on a pericellular matrix prepared from human decidua-derived mesenchymal cells.

Autor: Ryohei Numata, Naoki Okumura, Makiko Nakahara, Morio Ueno, Shigeru Kinoshita, Daisuke Kanematsu, Yonehiro Kanemura, Yoshiki Sasai, Noriko Koizumi

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e88169 (2014)

The barrier and pump functions of the corneal endothelium are essential for the maintenance of corneal transparency. Although corneal transplantation is the only current therapy for treating corneal endothelial dysfunction, the potential of tissue-en

Externí odkaz: https://doaj.org/article/4d090c9748184479a4754093701acb38

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Akademický článek

Corneal endothelial expansion promoted by human bone marrow mesenchymal stem cell-derived conditioned medium.

Autor: Makiko Nakahara, Naoki Okumura, EunDuck P Kay, Michio Hagiya, Kiwamu Imagawa, Yuuki Hosoda, Shigeru Kinoshita, Noriko Koizumi

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69009 (2013)

Healthy corneal endothelium is essential for maintaining corneal clarity, as the damage of corneal endothelial cells and loss of cell count causes severe visual impairment. Corneal transplantation is currently the only therapy for severe corneal diso

Externí odkaz: https://doaj.org/article/93ffed932fa84e4ca04bd66f442fb36f

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Akademický článek

Inhibition of TGF-β signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine.

Autor: Naoki Okumura, EunDuck P Kay, Makiko Nakahara, Junji Hamuro, Shigeru Kinoshita, Noriko Koizumi

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e58000 (2013)

Corneal endothelial dysfunctions occurring in patients with Fuchs' endothelial corneal dystrophy, pseudoexfoliation syndrome, corneal endotheliitis, and surgically induced corneal endothelial damage cause blindness due to the loss of endothelial func

Externí odkaz: https://doaj.org/article/1d4732e1bf6241769e429c85f2853e67

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