Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Makiko Miyota"'
Autor:
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, Takao Yogo, Tomohiro Yabushita, Ryoji Ito, Masaya Ueno, Atsushi Hirao, Kaoru Tohyama, Chao Li, Kimihito Cojin Kawabata, Kiyoshi Yamaguchi, Yoichi Furukawa, Hidetaka Kosako, Akihide Yoshimi, Susumu Goyama, Yasuhito Nannya, Seishi Ogawa, Karl Agger, Kristian Helin, Satoshi Yamazaki, Haruhiko Koseki, Noriko Doki, Yuka Harada, Hironori Harada, Atsuya Nishiyama, Makoto Nakanishi, Atsushi Iwama
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract DNA hypomethylating agents (HMAs) are used for the treatment of myeloid malignancies, although their therapeutic effects have been unsatisfactory. Here we show that CRISPR-Cas9 screening reveals that knockout of topoisomerase 1-binding argin
Externí odkaz:
https://doaj.org/article/d5c4ccd82b76400cb577a39dab027bde
Autor:
Yurie Nagai, Naoya Mimura, Ola Rizq, Yusuke Isshiki, Motohiko Oshima, Mohamed Rizk, Atsunori Saraya, Shuhei Koide, Yaeko Nakajima-Takagi, Makiko Miyota, Tetsuhiro Chiba, Nagisa Oshima-Hasegawa, Tomoya Muto, Shokichi Tsukamoto, Shio Mitsukawa, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Tohru Iseki, Chiaki Nakaseko, William Lennox, Josephine Sheedy, Marla Weetall, Koutaro Yokote, Atsushi Iwama, Emiko Sakaida
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and in combination with proteasome in
Externí odkaz:
https://doaj.org/article/481913bfae7549a8909dc48c57cf66bb
Autor:
Yurie Nagai, Koutaro Yokote, Ola Rizq, Motohiko Oshima, Tomoya Muto, William Joseph Lennox, Naoya Mimura, Yusuke Isshiki, Atsunori Saraya, Marla Weetall, Chiaki Nakaseko, Makiko Miyota, Shio Mitsukawa, Atsushi Iwama, Nagisa Oshima-Hasegawa, Emiko Sakaida, Chikako Ohwada, Josephine Sheedy, Tohru Iseki, Masahiro Takeuchi, Shokichi Tsukamoto, Tetsuhiro Chiba, Yusuke Takeda, Shuhei Koide, Mohamed S Rizk, Yaeko Nakajima-Takagi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
The novel small molecule PTC596 inhibits microtubule polymerization and its clinical development has been initiated for some solid cancers. We herein investigated the preclinical efficacy of PTC596 alone and in combination with proteasome inhibitors
Autor:
Yusuke Isshiki, Yurie Nagai, Chiaki Nakaseko, Tohru Iseki, Motohiko Oshima, Josephine Sheedy, Naoya Mimura, Shokichi Tsukamoto, Chikako Ohwada, Masahiro Takeuchi, Atsushi Iwama, Ola Rizq, Nagisa Oshima-Hasegawa, Yusuke Takeda, Atsunori Saraya, Shuhei Koide, Mohamed S Rizk, Emiko Sakaida, Yaeko Nakajima-Takagi, Marla Weetall, Makiko Miyota, Shio Mitsukawa
Publikováno v:
Blood. 134:4414-4414
Introduction: A novel tubulin binding agent PTC596, which is currently in clinical trials for solid tumors, was originally identified by its ability to kill cancer stem cells and to reduce BMI1 activity. PTC596 treatment results in hyperphosphorylati