Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Makiko, Ohshima"'
Autor:
Ruixin Zhang, Makiko Ohshima, David Brodin, Yu Wang, Antonin Morancé, Marianne Schultzberg, Gefei Chen, Jan Johansson
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Treatment strategies that are efficient against established Alzheimer’s disease (AD) are needed. BRICHOS is a molecular chaperone domain that prevents amyloid fibril formation and associated cellular toxicity. In this study, we treated an
Externí odkaz:
https://doaj.org/article/14bc5199eea643b4a95ca73805a29765
Autor:
Ying Wang, Xiang Zhang, Henrik Biverstål, Nicolas G. Bazan, Shuai Tan, Nailin Li, Makiko Ohshima, Marianne Schultzberg, Xiaofei Li
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 3, Pp 873-886 (2025)
Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer’s disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer’s disease to prevent/
Externí odkaz:
https://doaj.org/article/3f4f59af8c0646529376dd19b3de51ed
Autor:
Ceren Emre, Luis E. Arroyo-García, Khanh V. Do, Bokkyoo Jun, Makiko Ohshima, Silvia Gómez Alcalde, Megan L. Cothern, Silvia Maioli, Per Nilsson, Erik Hjorth, André Fisahn, Nicolas G. Bazan, Marianne Schultzberg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Intranasal administration of pro-resolving lipid mediators improves memory deficits and reduce microglial activation in a mouse model for Alzheimer’s disease, suggesting a future therapy.
Externí odkaz:
https://doaj.org/article/19b3984474bb4b898093a4daa1c00e69
Autor:
Igor Gurevich, Sarah A. Burton, Christie Munn, Makiko Ohshima, Madelyn E. Goedland, Katherine Czysz, Deepika Rajesh
Publikováno v:
Biology Open, Vol 9, Iss 12 (2020)
Non-alcoholic fatty liver disease (NAFLD) affects 30–40% of adults and 10% of children in the US. About 20% of people with NAFLD develop non-alcoholic steatohepatitis (NASH), which may lead to cirrhosis and liver cancer, and is projected to be a le
Externí odkaz:
https://doaj.org/article/e8c0715a47f54f449d8469feacbf692b
Autor:
Masahiro Tsuji, Makiko Ohshima, Yumi Yamamoto, Satoshi Saito, Yorito Hattori, Emi Tanaka, Akihiko Taguchi, Masafumi Ihara, Yuko Ogawa
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
People with Down syndrome, which is a trisomy of chromosome 21, exhibit intellectual disability from infancy and neuropathology similar to Alzheimer’s disease, such as amyloid plaques, from an early age. Recently, we showed that cilostazol, a selec
Externí odkaz:
https://doaj.org/article/05ac80529cf448cb93db6cef1c42fa94
Autor:
Khanh V. Do, Erik Hjorth, Ying Wang, Bokkyoo Jun, Marie-Audrey I. Kautzmann, Makiko Ohshima, Maria Eriksdotter, Marianne Schultzberg, Nicolas G. Bazan
Publikováno v:
Cellular and Molecular Neurobiology. 43:797-811
Alzheimer’s disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) can be used as intermediary diagnoses of increasing severity. Chronic neuroinflam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10806f575868ceeb8f2c31d93276f057
https://doi.org/10.1007/s10571-022-01216-5
https://doi.org/10.1007/s10571-022-01216-5
Autor:
Kai Zhou, Georgios Alkis Zisiadis, Monique Havermans, Cecilia Dominguez, Makiko Ohshima, Carlos F. D. Rodrigues, Klas Blomgren
Background Ablation of hippocampal neurogenesis is thought to be one reason behind the lifelong cognitive complications that childhood brain cancer survivors face after cranial radiotherapy. Microglia react strongly immediately after an irradiation i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28a5e2c29087ea94cf262467d2499c8
https://doi.org/10.21203/rs.3.rs-2681591/v1
https://doi.org/10.21203/rs.3.rs-2681591/v1
Autor:
Ceren, Emre, Luis E, Arroyo-García, Khanh V, Do, Bokkyoo, Jun, Makiko, Ohshima, Silvia Gómez, Alcalde, Megan L, Cothern, Silvia, Maioli, Per, Nilsson, Erik, Hjorth, André, Fisahn, Nicolas G, Bazan, Marianne, Schultzberg
Publikováno v:
Communications biology. 5(1)
Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer's disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49b6a4098f964266e6ef063034a195c1
https://pubmed.ncbi.nlm.nih.gov/35314851
https://pubmed.ncbi.nlm.nih.gov/35314851
Publikováno v:
BioResearch Open Access, Vol 8, Iss 1, Pp 200-209 (2019)
BioResearch Open Access
BioResearch Open Access
The strong barrier function of the blood–brain barrier (BBB) protects the central nervous system (CNS) from xenobiotic substances, while the expression of selective transporters controls the transportation of nutrients between the blood and brain.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5ade787ebc1c4c4fe5c7b77a45aad4
https://doi.org/10.1089/biores.2019.0026
https://doi.org/10.1089/biores.2019.0026
Autor:
Kenichi Yamahara, Kazuhiko Harada, Makiko Ohshima, Shin Ishikane, Shunsuke Ohnishi, Hidetoshi Tsuda, Kentaro Otani, Akihiko Taguchi, Toshihiro Soma, Hiroyasu Ogawa, Shinji Katsuragi, Jun Yoshimatsu, Mariko Harada-Shiba, Kenji Kangawa, Tomoaki Ikeda
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88319 (2014)
Although mesenchymal stem cells (MSCs) can be obtained from the fetal membrane (FM), little information is available regarding biological differences in MSCs derived from different layers of the FM or their therapeutic potential. Isolated MSCs from b
Externí odkaz:
https://doaj.org/article/cd3eb48bb5864dc2b39cc691ae0042c2