Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Maki MIYAMOTO"'
Autor:
Takao Mandai, Yuu Sako, Emi Kurimoto, Yuji Shimizu, Minoru Nakamura, Makoto Fushimi, Ryouta Maeda, Maki Miyamoto, Haruhide Kimura
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Abstract M1 muscarinic acetylcholine receptor (M1R) activation can be a new therapeutic approach for the treatment of cognitive deficits associated with cholinergic hypofunction. However, M1R activation causes gastrointestinal (GI) side effects in an
Externí odkaz:
https://doaj.org/article/1996db5c1bb74209a2c1a0e72f2d9b18
Autor:
Kenichi Iwai, Masahiro Yaguchi, Kazuho Nishimura, Yukiko Yamamoto, Toshiya Tamura, Daisuke Nakata, Ryo Dairiki, Yoichi Kawakita, Ryo Mizojiri, Yoshiteru Ito, Moriteru Asano, Hironobu Maezaki, Yusuke Nakayama, Misato Kaishima, Kozo Hayashi, Mika Teratani, Shuichi Miyakawa, Misa Iwatani, Maki Miyamoto, Michael G Klein, Wes Lane, Gyorgy Snell, Richard Tjhen, Xingyue He, Sai Pulukuri, Toshiyuki Nomura
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 6, Pp 1-15 (2018)
Abstract The modulation of pre‐mRNA splicing is proposed as an attractive anti‐neoplastic strategy, especially for the cancers that exhibit aberrant pre‐mRNA splicing. Here, we discovered that T‐025 functions as an orally available and potent
Externí odkaz:
https://doaj.org/article/5f979a579b0246ad90c5cfcded6e406d
Publikováno v:
Respirology Case Reports, Vol 7, Iss 7, Pp n/a-n/a (2019)
Nocardiosis is an uncommon infection caused by Nocardia species, but it can often occur in immunocompromised patients. As computed tomography (CT) findings of pulmonary nocardiosis, consolidation, masses, and nodules are often found, but lymph node e
Externí odkaz:
https://doaj.org/article/5d85f10a0a3a4adb83cc4c3a967fdef7
Publikováno v:
High Voltage (2017)
Cable-grade silicone rubber was aged thermally or by combining heat and gamma-ray radiation, and resultant changes in chemical, thermal, mechanical and electrical properties were examined. The experimental results obtained in these analyses are clear
Externí odkaz:
https://doaj.org/article/80669563b2cf4c8289e35b19d868951a
Autor:
Akina Harada, Kazunori Suzuki, Naomi Kamiguchi, Maki Miyamoto, Kimio Tohyama, Kosuke Nakashima, Takahiko Taniguchi, Haruhide Kimura
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122197 (2015)
Phosphodiesterase 10A (PDE10A) inhibition is a novel and promising approach for the treatment of central nervous system disorders such as schizophrenia and Huntington's disease. A novel PDE10A inhibitor, TAK-063 [1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl
Externí odkaz:
https://doaj.org/article/68f3374951714c6daf7aaec04f3b8474
Autor:
Akihiro Ohashi, Momoko Ohori, Kenichi Iwai, Tadahiro Nambu, Maki Miyamoto, Tomohiro Kawamoto, Masanori Okaniwa
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144675 (2015)
Centromere-associated protein E (CENP-E) regulates both chromosome congression and the spindle assembly checkpoint (SAC) during mitosis. The loss of CENP-E function causes chromosome misalignment, leading to SAC activation and apoptosis during prolon
Externí odkaz:
https://doaj.org/article/da42cd14ef954614b2ceb184d31e0661
Autor:
Maki Miyamoto1, Yamada, Tomohito J.2 miyamoto@elms.hokudai.ac.jp
Publikováno v:
Hydrological Research Letters. 2024, Vol. 18 Issue 1, p28-34. 7p.
Autor:
Cristian Constantinescu, David Alagille, Caroline Papin, Eiji Sunahara, Shuhei Ikeda, Tatsuki Koike, Maki Miyamoto, John Seibyl, Gilles Tamagnan, Olivier Barret, Thomas J. Morley, Krista Fowles, Patricia E. Cole, Takanobu Kuroita, Toshiya Nishi
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 49:1148-1156
Purpose Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that plays a major role in brain cholesterol homeostasis by converting cholesterol into 24S-hydroxycholesterol. The selective CH24H inhibitor soticlestat (TAK-935) is being pursued
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c3b49ad503abe1c9b276111d06b8346
https://doi.org/10.1007/s00259-021-05565-z
https://doi.org/10.1007/s00259-021-05565-z
Autor:
Tomohiro Ohashi, Tomoteru Yamasaki, Yasuyuki Debori, Tatsuki Koike, Tomokazu Kusumoto, Ryouta Maeda, Masayuki Fujinaga, Akito Hata, Takeshi Wakabayashi, Yasushi Hattori, Ming-Rong Zhang, Miyanohana Yuhei, Ryo Yamashita, Maki Miyamoto, Yiding Zhang, Hidekatsu Wakizaka
Publikováno v:
Journal of Medicinal Chemistry. 64:11990-12002
Diacylglycerol kinase gamma (DGKγ) is a subtype of DGK enzyme, which catalyzes ATP-dependent conversion of diacylglycerol to phosphatidic acid. DGKγ, localized in the brain, plays an important role in the central nervous system. However, its functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fed7abf826a7d32a1858fd3c81b3bef
https://doi.org/10.1021/acs.jmedchem.1c00584
https://doi.org/10.1021/acs.jmedchem.1c00584
Autor:
Toshiya Nishi, Cameron S. Metcalf, Shinji Fujimoto, Shigeo Hasegawa, Maki Miyamoto, Eiji Sunahara, Sayuri Watanabe, Shinichi Kondo, H. Steve White
Publikováno v:
Epilepsia. 63(6)
The formation of 24S-hydroxycholesterol is a brain-specific mechanism of cholesterol catabolism catalyzed by cholesterol 24-hydroxylase (CYP46A1, also known as CH24H). CH24H has been implicated in various biological mechanisms, whereas pharmacologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5fc7b5260a91d1b998d234df7d07e8
https://pubmed.ncbi.nlm.nih.gov/35316533
https://pubmed.ncbi.nlm.nih.gov/35316533