Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Maki Kanesaka"'
Autor:
Toshiyuki Takahashi, Shigeru Tokita, Nagaaki Sato, Takashi Mizutani, Tsuyoshi Nagase, Maki Kanesaka, Takahide Sasaki, Norihiro Takenaga, Ryo Yoshimoto, Yuko Mitobe, Sayaka Ito, Takeshi Tanaka, Yasuhisa Miyamoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4232-4236
A series of novel dihydrobenzoxathiin derivatives was synthesized and evaluated as potent human histamine H3 receptor inverse agonists. After systematic modification of lead 1a, the potent and selective histamine H3 inverse agonist 1-(3-{4-[(2S,3S)-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a46737c17f95d721cb873a818e2822
https://doi.org/10.1016/j.bmcl.2009.05.101
https://doi.org/10.1016/j.bmcl.2009.05.101
Autor:
Ken Shimamura, Katsumi Aragane, Toshiyuki Takahashi, Maki Kanesaka, Yasuhisa Miyamoto, Shigeru Tokita, Takahide Sasaki, Tsuyoshi Nagase, Ryo Yoshimoto, Hidefumi Kitazawa, Nagaaki Sato, Akira Nagumo
Publikováno v:
Journal of Medicinal Chemistry. 52:4111-4114
Long chain fatty acid elongase 6 (ELOVL6) catalyzes the elongation of long chain fatty acyl-CoAs and is a potential target for the treatment of metabolic disorders. The ultrahigh throughput screen of our corporate chemical collections resulted in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464844a9a0dc51ceb1eda04f4e37e2b
https://doi.org/10.1021/jm900488k
https://doi.org/10.1021/jm900488k
Autor:
Hisashi Iwaasa, Yoshikazu Nagae, Akio Kanatani, Tetsuya Kanno, Maki Kanesaka, Tomoyuki Ohe, Junko Ito, Minoru Moriya, Takehiro Fukami, Kenji Matsuda, Yuko Mitobe, Makoto Ishikawa, Yoshio Ogino, Akane Ishihara, Norikazu Ohtake
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4997-5001
Syntheses and structure-activity relationships of a novel class of 2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists are described. Optimization of the lead compound 2a by incorporating substituents into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7b700b4ddf9680a2674ec427dc47ec
https://doi.org/10.1016/j.bmcl.2008.08.021
https://doi.org/10.1016/j.bmcl.2008.08.021
Publikováno v:
Journal of Peptide Science. 13:379-385
Neuropeptide B (NPB) has been recently identified as an endogenous ligand for GPR7 (NPBW1) and GPR8 (NPBW2) and has been shown to possess a relatively high selectivity for GPR7. In order to identify useful experimental tools to address physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efbefe9f351813c28deb2cd4dc3fca64
https://doi.org/10.1002/psc.855
https://doi.org/10.1002/psc.855
Autor:
Yasuyuki Ishii, Tetsuya Kanno, Maki Kanesaka, Satoshi Mashiko, Masaki Ihara, Akane Ishihara, Mikiko Hata, Masahiko Kobayashi, Yushin Tominaga, Megumu Okada, Takehiro Fukami, Takashi Murai, Takeshi Tanaka, Keiko Watanabe, Akio Kanatani, Akira Gomori, Masayasu Hidaka, Takahiro Fukuroda, Nagaaki Sato
Publikováno v:
British Journal of Pharmacology. 136:341-346
An experiment was conducted to examine whether a potent, orally active and highly selective neuropeptide Y Y1 receptor antagonist attenuates hyperphagia and obesity in genetically obese Zucker fatty rats. Oral administration of the Y1 antagonist (30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a87d1e9e3c6876d145569ef7f8f48d8
https://doi.org/10.1038/sj.bjp.0704696
https://doi.org/10.1038/sj.bjp.0704696
Autor:
Yasuhisa Miyamoto, Ken Shimamura, Hidefumi Kitazawa, Naomi Morita, Shigeru Tokita, Katsumi Aragane, Toshiyuki Takahashi, Tomoyuki Ohe, Nagaaki Sato, Ryo Yoshimoto, Tsuyoshi Nagase, Maki Kanesaka, Akira Nagumo
Publikováno v:
European journal of pharmacology. 630(1-3)
The elongase of long chain fatty acids family 6 (ELOVL6) is a rate-limiting enzyme for the elongation of saturated and monounsaturated long chain fatty acids. ELOVL6 is abundantly expressed in lipogenic tissues such as liver, and its mRNA expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5964cf4f3326a726a3f491c4666a977
https://pubmed.ncbi.nlm.nih.gov/20045404
https://pubmed.ncbi.nlm.nih.gov/20045404
Autor:
Takahide Sasaki, Akira Nagumo, Ryo Yoshimoto, Toshiyuki Takahashi, Hidefumi Kitazawa, Yasuhisa Miyamoto, Shigeru Tokita, Maki Kanesaka, Katsumi Aragane, Ken Shimamura, Nagaaki Sato, Tsuyoshi Nagase
Publikováno v:
Journal of medicinal chemistry. 52(10)
Novel indoledione derivatives were synthesized and evaluated as long chain fatty acid elongase 6 (ELOVL6) inhibitors. Systematic optimization of an indole class of lead 1 led to the identification of potent ELOVL6 selective inhibitors. Representative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854125f535cc19905af67196bd550649
https://pubmed.ncbi.nlm.nih.gov/19388647
https://pubmed.ncbi.nlm.nih.gov/19388647
Autor:
Hidefumi Kitazawa, Tsuyoshi Nagase, Takahide Sasaki, Ken Shimamura, Maki Kanesaka, Ryo Yoshimoto, Yasuhisa Miyamoto, Katsumi Aragane, Akira Nagumo, Nagaaki Sato, Toshiyuki Takahashi, Shigeru Tokita
Publikováno v:
Bioorganicmedicinal chemistry. 17(15)
A series of novel 2-azabicyclo[2.2.2]octane derivatives was synthesized and evaluated as long chain fatty acid elongase 6 (ELOVL6) inhibitors. Screening of our corporate chemical collections against ELOVL6 resulted in the identification of lead 1. Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0277260723861742e02f860efc674f
https://pubmed.ncbi.nlm.nih.gov/19596583
https://pubmed.ncbi.nlm.nih.gov/19596583
Autor:
Tsuyoshi Nagase, Yasuhisa Miyamoto, Hidefumi Kitazawa, Shigeru Tokita, Naomi Morita, Ken Shimamura, Ryo Yoshimoto, Katsumi Aragane, Toshiyuki Takahashi, Akira Nagumo, Maki Kanesaka, Tomoyuki Ohe, Nagaaki Sato
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 330(1)
Long-chain fatty acid elongases reside in the endoplasmic reticulum and are responsible for the rate-limiting step of the elongation of long-chain fatty acids. The elongase of long-chain fatty acids (ELOVL) family 6 (ELOVL6) is involved in the elonga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e60e74a3833aaa37b7fd872649d97a2
https://pubmed.ncbi.nlm.nih.gov/19359527
https://pubmed.ncbi.nlm.nih.gov/19359527
Autor:
Akane, Ishihara, Akio, Kanatani, Megumu, Okada, Masayasu, Hidaka, Takeshi, Tanaka, Satoshi, Mashiko, Akira, Gomori, Tetsuya, Kanno, Mikiko, Hata, Maki, Kanesaka, Yushin, Tominaga, Naga-aki, Sato, Masahiko, Kobayashi, Takashi, Murai, Keiko, Watanabe, Yasuyuki, Ishii, Takahiro, Fukuroda, Takehiro, Fukami, Masaki, Ihara
Publikováno v:
British journal of pharmacology. 136(3)
1. An experiment was conducted to examine whether a potent, orally active and highly selective neuropeptide Y Y1 receptor antagonist attenuates hyperphagia and obesity in genetically obese Zucker fatty rats. 2. Oral administration of the Y1 antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1609d281bdd8fd480b77f74548cdebf9
https://pubmed.ncbi.nlm.nih.gov/12023935
https://pubmed.ncbi.nlm.nih.gov/12023935