Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Maki Iwago"'
Autor:
Shuhei Kanagaki, Yusuke Tsutsui, Naoki Kobayashi, Takashi Komine, Minoru Ito, Yunike Akasaka, Michiaki Nagasawa, Tomohiro Ide, Naoki Omae, Kazuhisa Nakao, Makoto Rembutsu, Maki Iwago, Aki Yonezawa, Yusei Hosokawa, Tetsuya Hosooka, Wataru Ogawa, Koji Murakami
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106293- (2023)
Summary: 5′-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in cultu
Externí odkaz:
https://doaj.org/article/a92b50733fa44d83b46f3299ab983040
Autor:
Tohru Ichimura, Maki Iwago, Hossain Uddin Shekhar, Takeshi Goma, Yoshinori Ohsumi, Takashi Shinkawa, Toshiaki Isobe, Takashi Ito, Noboru Mizushima, Masato Taoka, Hiroyuki Kubota, Kazue Kakiuchi
Publikováno v:
Biochemistry. 43:6149-6158
BMH1 and BMH2 encode Saccharomyces cerevisiae 14-3-3 homologues whose exact functions have remained unclear. The present work compares the transcriptomic and proteomic profiles of the wild type and a BMH1/2-deficient S. cerevisiae mutant (bmhDelta) u
Autor:
Kazuhiko Yumoto, Koji Murakami, Shigeki Seto, Reiko Terasawa, Yasushi Kohno, Kevin R. Shreder, Aya Iwane, Yoshikazu Asahina, Maki Iwago, Kyoko Okada
Publikováno v:
Bioorganicmedicinal chemistry. 20(3)
The design, synthesis, and evaluation of 6-6-7 tricyclic quinolones containing the strained spirocycle moiety aiming at the GSK-3β inhibitor were described. Among the synthesized compounds, 44, having a cyclobutane ring on a spirocycle, showed excel
Autor:
Yasushi Kohno, Koji Murakami, Shigeki Seto, Maki Iwago, Kyoko Okada, Shigeki Isogai, Takehiro Shinozaki, Yoshiaki Kitamura, Koichi Kiyota
Publikováno v:
Journal of medicinal chemistry. 53(13)
A series of novel 2,4,6-trisubstitutedpyrimidine-5-carboxylic acid derivatives were designed and synthesized with the intent of producing a peroxisome proliferator-activated receptor gamma (PPARgamma) partial agonist for antidiabetic agents. A pharma
Autor:
Kazue Kakiuchi, Yoshio Yamauchi, Akira Sakai, Takashi Ito, Maki Iwago, Tohru Ichimura, Tomoko Fujita, Toshiaki Isobe, Masato Taoka, Si-Young Song
Publikováno v:
Biochemistry. 46(26)
The yeast Saccharomyces cerevisiae produces two 14-3-3 proteins, Bmh1 and Bmh2, whose exact functions have remained unclear. Here, we performed a comprehensive proteomic analysis using multistep immunoaffinity purification and mass spectrometry and i