Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Maki, Nakayama"'
Autor:
Peter S. Linsley, Maki Nakayama, Elisa Balmas, Janice Chen, Fariba Barahmand-pour-Whitman, Shubham Bansal, Ty Bottorff, Elisavet Serti, Cate Speake, Alberto Pugliese, Karen Cerosaletti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet antigen-reactive (IAR) CD4+ memory T cells from peripheral blood affect T1D progress
Externí odkaz:
https://doaj.org/article/66f2c80699f6498b86e42acf78ab840a
Autor:
Stephanie J. Hanna, Terri C. Thayer, Emma J. S. Robinson, Ngoc-Nga Vinh, Nigel Williams, Laurie G. Landry, Robert Andrews, Qi Zhuang Siah, Pia Leete, Rebecca Wyatt, Martina A. McAteer, Maki Nakayama, F. Susan Wong, Jennie H. M. Yang, Timothy I. M. Tree, Johnny Ludvigsson, Colin M. Dayan, Danijela Tatovic
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that intradermal injection of GNPs loaded with the proinsulin peptide C19-A3, in p
Externí odkaz:
https://doaj.org/article/53e6f7919fde4d98856728343312e345
Autor:
Angela M. Mitchell, Erin E. Baschal, Kristen A. McDaniel, Kimber M. Simmons, Laura Pyle, Kathleen Waugh, Andrea K. Steck, Liping Yu, Peter A. Gottlieb, Marian J. Rewers, Maki Nakayama, Aaron W. Michels
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
T cell receptor (TCR) sequences are exceptionally diverse and can now be comprehensively measured with next-generation sequencing technologies. However, a thorough investigation of longitudinal TCR repertoires throughout childhood in health and durin
Externí odkaz:
https://doaj.org/article/fdd60e79e23f4d1292274bdb7907007f
Autor:
Janet M. Wenzlau, James E. DiLisio, Gene Barbour, Mylinh Dang, Anita C. Hohenstein, Maki Nakayama, Thomas Delong, Rocky L. Baker, Kathryn Haskins
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Insulin is considered to be a key antigenic target of T cells in Type 1 Diabetes (T1D) and autoimmune diabetes in the NOD mouse with particular focus on the B-chain amino acid sequence B:9-23 as the primary epitope. Our lab previously discovered that
Externí odkaz:
https://doaj.org/article/d76cc12a82c74f1d8df87c2551cce996
Autor:
Maki Nakayama, Aaron W. Michels
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
T cell receptors (TCRs) are unique markers that define antigen specificity for a given T cell. With the evolution of sequencing and computational analysis technologies, TCRs are now prime candidates for the development of next-generation non-cell bas
Externí odkaz:
https://doaj.org/article/60aa1c3c389c4b8aad4bb498f379bb27
Autor:
Timothy A. Wiles, Anita Hohenstein, Laurie G. Landry, Mylinh Dang, Roger Powell, Perrin Guyer, Eddie A. James, Maki Nakayama, Kathryn Haskins, Thomas Delong, Rocky L. Baker
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Hybrid Insulin Peptides (HIPs), which consist of insulin fragments fused to other peptides from β-cell secretory granule proteins, are CD4 T cell autoantigens in type 1 diabetes (T1D). We have studied HIPs and HIP-reactive CD4 T cells extensively in
Externí odkaz:
https://doaj.org/article/e186d718d2c24746bca1962867bcb7b6
Autor:
Laurie G. Landry, Amanda M. Anderson, Holger A. Russ, Liping Yu, Sally C. Kent, Mark A. Atkinson, Clayton E. Mathews, Aaron W. Michels, Maki Nakayama
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Proinsulin is an abundant protein that is selectively expressed by pancreatic beta cells and has been a focus for development of antigen-specific immunotherapies for type 1 diabetes (T1D). In this study, we sought to comprehensively evaluate reactivi
Externí odkaz:
https://doaj.org/article/a91cd3ee2151464383c8205ba8eb1435
Publikováno v:
Bio-Protocol, Vol 11, Iss 2 (2021)
Immune tolerance and response are both largely driven by the interactions between the major histocompatibility complex (MHC) expressed by antigen presenting cells (APCs), T-cell receptors (TCRs) on T-cells, and their cognate antigens. Disordered inte
Externí odkaz:
https://doaj.org/article/6d839bae5126451aa541bf9e3febb0f4
Autor:
Sarah E. Mann, Zhicheng Zhou, Laurie G. Landry, Amanda M. Anderson, Aimon K. Alkanani, Jeremy Fischer, Mark Peakman, Roberto Mallone, Kristen Campbell, Aaron W. Michels, Maki Nakayama
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Recent advancements in single cell sequencing technologies allow for identification of numerous immune-receptors expressed by T cells such as tumor-specific and autoimmune T cells. Determining antigen specificity of those cells holds immense therapeu
Externí odkaz:
https://doaj.org/article/1ad9f4fd08954056b50904453b43f4fa
Autor:
Rachel Madley, Grace Nauman, Nichole Danzl, Chiara Borsotti, Mohsen Khosravi Maharlooei, Hao Wei Li, Estefania Chavez, Remi J. Creusot, Maki Nakayama, Bart Roep, Megan Sykes
Publikováno v:
Journal of Translational Autoimmunity, Vol 3, Iss , Pp 100061- (2020)
During T cell development in mice, thymic negative selection deletes cells with the potential to recognize and react to self-antigens. In human T cell-dependent autoimmune diseases such as Type 1 diabetes, multiple sclerosis, and rheumatoid arthritis
Externí odkaz:
https://doaj.org/article/fd371e44d6c349c8a63babcc085673e7