Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases

Autor: Makhoba XH, Viegas Jr C, Mosa RA, Viegas FPD, Pooe OJ

Publikováno v: Drug Design, Development and Therapy, Vol Volume 14, Pp 3235-3249 (2020)

Xolani H Makhoba,1 Claudio Viegas Jr,2 Rebamang A Mosa,1 Flávia PD Viegas,2 Ofentse J Pooe3 1Department of Biochemistry, Genetics and Microbiology, Division of Biochemistry, University of Pretoria, Hatfield, South Africa; 2Laboratory of Research in

Externí odkaz: https://doaj.org/article/9817c2ef058d4755a509562a63eb20a4

A comprehensive review of the interaction between COVID-19 spike proteins with mammalian small and major heat shock proteins.

Autor: Navhaya LT; Department of Biochemistry, Microbiology and Biotechnology, University of Limpopo, Turfloop Campus, Sovenga, 0727, South Africa., Blessing DM; Department of Biochemistry and Microbiology, University of Fort Hare, Alice Campus, 1 King Williams Town, 5700, South Africa., Yamkela M; Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa (UNISA), Florida Campus, Roodepoort, 1709, South Africa., Godlo S; Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa (UNISA), Florida Campus, Roodepoort, 1709, South Africa., Makhoba XH; Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, University of South Africa (UNISA), Florida Campus, Roodepoort, 1709, South Africa.

Publikováno v: Biomolecular concepts [Biomol Concepts] 2024 Jun 14; Vol. 15 (1). Date of Electronic Publication: 2024 Jun 14 (Print Publication: 2024).

An Undefined Interaction between Polyamines and Heat Shock Proteins Leads to Cellular Protection in Plasmodium falciparum and Proliferating Cells in Various Organisms.

Autor: Makhoba XH; Department of Biochemistry, Microbiology, and Biotechnology, School of Molecular and Life Science, University of Limpopo, Turfloop Campus, Sovenga 0727, South Africa., Ragno R; Rome Center for Molecular Design, Department of Drug Chemistry and Technology, Sapienza University, P. le A. Moro 5, 00185 Rome, Italy., Kaiser A; Medical Research Centre, University of Duisburg-Essen, Hufeland Strasse 55, 45147 Essen, Germany., Agostinelli E; Department of Sensory Organs, Sapienza University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy.; International Polyamines Foundation 'ETS-ONLUS', Via del Forte Tiburtino 98, 00159 Rome, Italy.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2023 Feb 10; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 10.

Protein PEGylation: Navigating Recombinant Protein Stability, Aggregation, and Bioactivity.

Autor: Zuma LK; Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Westville, 3629 KwaZulu-Natal, South Africa., Gasa NL; Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Westville, 3629 KwaZulu-Natal, South Africa., Makhoba XH; Department of Biochemistry and Microbiology, University of Fort Hare, Alice Campus, Alice, 5700 Eastern Cape, South Africa., Pooe OJ; Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Westville, 3629 KwaZulu-Natal, South Africa.

Publikováno v: BioMed research international [Biomed Res Int] 2022 Jul 25; Vol. 2022, pp. 8929715. Date of Electronic Publication: 2022 Jul 25 (Print Publication: 2022).

Comparative Characterization of Plasmodium falciparum Hsp70-1 Relative to E. coli DnaK Reveals the Functional Specificity of the Parasite Chaperone.

Autor: Lebepe CM; Department of Biochemistry, School of Mathematical & Natural Sciences, University of Venda, Thohoyandou 0950, South Africa., Matambanadzo PR; Department of Biochemistry, School of Mathematical & Natural Sciences, University of Venda, Thohoyandou 0950, South Africa., Makhoba XH; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria 0028, South Africa., Achilonu I; Protein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg 2050, South Africa., Zininga T; Department of Biochemistry, School of Mathematical & Natural Sciences, University of Venda, Thohoyandou 0950, South Africa.; Department of Biochemistry, Stellenbosch University, Stellenbosch 7602, South Africa., Shonhai A; Department of Biochemistry, School of Mathematical & Natural Sciences, University of Venda, Thohoyandou 0950, South Africa.

Publikováno v: Biomolecules [Biomolecules] 2020 Jun 04; Vol. 10 (6). Date of Electronic Publication: 2020 Jun 04.