HIV-1C in-House RNA-Based Genotyping Assay for Detection of Drug Resistance Mutations in Samples with Low-Level Viral Loads

Autor: Bareng OT, Choga WT, Maphorisa ST, Seselamarumo S, Seatla KK, Mokgethi PT, Maruapula D, Mogwele ML, Ditshwanelo D, Moraka NO, Gobe I, Motswaledi MS, Makhema JM, Musonda R, Shapiro R, Essex M, Novitsky V, Moyo S, Gaseitsiwe S

Publikováno v: Infection and Drug Resistance, Vol Volume 15, Pp 7565-7576 (2022)

Ontlametse T Bareng,1,2 Wonderful T Choga,1,2 Segomotso T Maphorisa,3 Sekgabo Seselamarumo,1 Kaelo K Seatla,1 Patrick T Mokgethi,1,4 Dorcas Maruapula,1,4 Mompati L Mogwele,1 Doreen Ditshwanelo,1,5 Natasha O Moraka,1 Irene Gobe,2 Modisa S Motswaledi,2

Externí odkaz: https://doaj.org/article/846ef3e83d94460f975dd8d7a30b1b13

Predictors of HIV seroconversion in Botswana: machine learning analysis in a representative, population-based HIV incidence cohort.

Autor: Cui Y; Center for Data Science, Zhejiang University, Hangzhou, Zhejiang, China., Moyo S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Botswana Harvard Health Partnership, Gaborone, Botswana.; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa., Pretorius Holme M; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Hurwitz KE; Target RWE, Durham, North Carolina., Choga W; Botswana Harvard Health Partnership, Gaborone, Botswana.; Division of Medical Virology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Cape Town, South Africa.; School of Allied Health Sciences, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana.; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa., Bennett K; Target RWE, Durham, North Carolina., Chakalisa U; Botswana Harvard Health Partnership, Gaborone, Botswana., San JE; Department of Internal Medicine, University of Botswana, Gaborone, Botswana.; Department of Statistics and Data Science, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA., Manyake K; Botswana Harvard Health Partnership, Gaborone, Botswana., Kgathi C; Botswana Harvard Health Partnership, Gaborone, Botswana., Diphoko A; Botswana Harvard Health Partnership, Gaborone, Botswana., Gaseitsiwe S; Botswana Harvard Health Partnership, Gaborone, Botswana., Gaolathe T; Botswana Harvard Health Partnership, Gaborone, Botswana.; Department of Internal Medicine, University of Botswana, Gaborone, Botswana., Essex M; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Botswana Harvard Health Partnership, Gaborone, Botswana., Tchetgen Tchetgen E; Department of Statistics and Data Science, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics and Epidemiology, The Wharton School, University of Pennsylvania, Philadelphia, PA, USA., Makhema JM; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Botswana Harvard Health Partnership, Gaborone, Botswana., Lockman S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Botswana Harvard Health Partnership, Gaborone, Botswana.; Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA, USA.

Publikováno v: AIDS (London, England) [AIDS] 2024 Nov 04. Date of Electronic Publication: 2024 Nov 04.

Predicted resistance to broadly neutralizing antibodies (bnAbs) and associated HIV-1 envelope characteristics among seroconverting adults in Botswana.

Autor: Moraka NO; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Choga WT; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Pema MN; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Chawawa MK; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Gobe I; School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana., Mokomane M; School of Allied Health Professions, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana., Bareng OT; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Bhebhe L; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Kelentse N; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Mulenga G; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Pretorius Holme M; Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Mohammed T; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Koofhethile CK; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Makhema JM; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Shapiro R; Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Lockman S; Harvard T. H. Chan School of Public Health, Harvard University, Boston, MA, USA., Moyo S; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana., Gaseitsiwe S; Botswana Harvard AIDS Institute Partnership, Bontleng, Private Bag BO320, Gaborone, Botswana. sgaseitsiwe@bhp.org.bw.

Publikováno v: Scientific reports [Sci Rep] 2023 Oct 24; Vol. 13 (1), pp. 18134. Date of Electronic Publication: 2023 Oct 24.

Lower academic performance among children with perinatal HIV exposure in Botswana.

Autor: Powis KM; Department of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Botswana Harvard Health Partnership, Gaborone, Botswana., Lebanna L; Department of Curriculum Development and Evaluation, Botswana Ministry of Basic Education, Gaborone, Botswana., Schenkel S; Department of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA., Masasa G; Botswana Harvard Health Partnership, Gaborone, Botswana., Kgole SW; Botswana Harvard Health Partnership, Gaborone, Botswana., Ngwaca M; Botswana Harvard Health Partnership, Gaborone, Botswana., Kgathi C; Botswana Harvard Health Partnership, Gaborone, Botswana., Williams PL; Departments of Biostatistics and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Slogrove AL; Department of Paediatrics & Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Worcester, South Africa., Shapiro RL; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Botswana Harvard Health Partnership, Gaborone, Botswana., Lockman S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Botswana Harvard Health Partnership, Gaborone, Botswana.; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA., Mmalane MO; Botswana Harvard Health Partnership, Gaborone, Botswana., Makhema JM; Botswana Harvard Health Partnership, Gaborone, Botswana., Jao J; Botswana Harvard Health Partnership, Gaborone, Botswana.; Department of Pediatrics, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA., Cassidy AR; Botswana Harvard Health Partnership, Gaborone, Botswana.; Departments of Psychiatry & Psychology and Pediatric & Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Publikováno v: Journal of the International AIDS Society [J Int AIDS Soc] 2023 Oct; Vol. 26 Suppl 4, pp. e26165.

Doravirine-associated resistance mutations in antiretroviral therapy naïve and experienced adults with HIV-1 subtype C infection in Botswana.

Autor: Bareng OT; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana, Gaborone, Botswana., Seselamarumo S; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone, Botswana., Seatla KK; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana, Gaborone, Botswana., Choga WT; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Division of Human Genetics, Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Bakae B; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana., Maruapula D; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone, Botswana., Kelentse N; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana, Gaborone, Botswana., Moraka NO; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Division of Medical Virology, Stellenbosch University, Cape Town, South Africa., Mokaleng B; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Medical Sciences, Faculty of Allied Health Professions, University of Botswana, Gaborone, Botswana., Mokgethi PT; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone, Botswana., Ditlhako TR; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana., Pretorius-Holme M; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Mbulawa MB; Ministry of Health, Republic of Botswana, Gaborone, Botswana., Lebelonyane R; Ministry of Health, Republic of Botswana, Gaborone, Botswana., Bile EC; FHI 360, Department of Clinical Sciences, Durham, North Carolina, USA., Gaolathe T; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana., Shapiro R; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Makhema JM; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Lockman S; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA; Brigham and Women's Hospital, Boston, Massachusetts, USA., Essex M; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Novitsky V; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Mpoloka SW; Department of Biological Sciences, Faculty of Science, University of Botswana, Gaborone, Botswana., Moyo S; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., Gaseitsiwe S; Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Electronic address: sgaseitsiwe@bhp.org.bw.

Publikováno v: Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2022 Dec; Vol. 31, pp. 128-134. Date of Electronic Publication: 2022 Aug 13.