Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Autor: Grapotte M., Saraswat M., Bessiere C., Menichelli C., Ramilowski J. A., Severin J., Hayashizaki Y., Itoh M., Tagami M., Murata M., Kojima-Ishiyama M., Noma S., Noguchi S., Kasukawa T., Hasegawa A., Suzuki H., Nishiyori-Sueki H., Frith M. C., Abugessaisa I., Aitken S., Aken B. L., Alam I., Alam T., Alasiri R., Alhendi A. M. N., Alinejad-Rokny H., Alvarez M. J., Andersson R., Arakawa T., Araki M., Arbel T., Archer J., Archibald A. L., Arner E., Arner P., Asai K., Ashoor H., Astrom G., Babina M., Baillie J. K., Bajic V. B., Bajpai A., Baker S., Baldarelli R. M., Balic A., Bansal M., Batagov A. O., Batzoglou S., Beckhouse A. G., Beltrami A. P., Beltrami C. A., Bertin N., Bhattacharya S., Bickel P. J., Blake J. A., Blanchette M., Bodega B., Bonetti A., Bono H., Bornholdt J., Bttcher M., Bougouffa S., Boyd M., Breda J., Brombacher F., Brown J. B., Bult C. J., Burroughs A. M., Burt D. W., Busch A., Caglio G., Califano A., Cameron C. J., Cannistraci C. V., Carbone A., Carlisle A. J., Carninci P., Carter K. W., Cesselli D., Chang J. -C., Chen J. C., Chen Y., Chierici M., Christodoulou J., Ciani Y., Clark E. L., Coskun M., Dalby M., Dalla E., Daub C. O., Davis C. A., de Hoon M. J. L., de Rie D., Denisenko E., Deplancke B., Detmar M., Deviatiiarov R., Di Bernardo D., Diehl A. D., Dieterich L. C., Dimont E., Djebali S., Dohi T., Dostie J., Drablos F., Edge A. S. B., Edinger M., Ehrlund A., Ekwall K., Elofsson A., Endoh M., Enomoto H., Enomoto S., Faghihi M., Fagiolini M., Farach-Carson M. C., Faulkner G. J., Favorov A., Fernandes A. M., Ferrai C., Forrest A. R. R., Forrester L. M., Forsberg M., Fort A., Francescatto M., Freeman T. C., Frith M., Fukuda S., Funayama M., Furlanello C., Furuno M., Furusawa C., Gao H., Gazova I., Gebhard C., Geier F., Geijtenbeek T. B. H., Ghosh S., Ghosheh Y., Gingeras T. R., Gojobori T., Goldberg T., Goldowitz D., Gough J., Greco D., Gruber A. J., Guhl S., Guigo R., Guler R., Gusev O., Gustincich S., Ha T. J., Haberle V., Hale P., Hallstrom B. M., Hamada M., Handoko L., Hara M., Harbers M., Harrow J., Harshbarger J., Hase T., Hashimoto K., Hatano T., Hattori N., Hayashi R., Herlyn M., Hettne K., Heutink P., Hide W., Hitchens K. J., Sui S. H., 't Hoen P. A. C., Hon C. C., Hori F., Horie M., Horimoto K., Horton P., Hou R., Huang E., Huang Y., Hugues R., Hume D., Ienasescu H., Iida K., Ikawa T., Ikemura T., Ikeo K., Inoue N., Ishizu Y., Ito Y., Ivshina A. V., Jankovic B. R., Jenjaroenpun P., Johnson R., Jorgensen M., Jorjani H., Joshi A., Jurman G., Kaczkowski B., Kai C., Kaida K., Kajiyama K., Kaliyaperumal R., Kaminuma E., Kanaya T., Kaneda H., Kapranov P., Kasianov A. S., Katayama T., Kato S., Kawaguchi S., Kawai J., Kawaji H., Kawamoto H., Kawamura Y. I., Kawasaki S., Kawashima T., Kempfle J. S., Kenna T. J., Kere J., Khachigian L., Kiryu H., Kishima M., Kitajima H., Kitamura T., Kitano H., Klaric E., Klepper K., Klinken S. P., Kloppmann E., Knox A. J., Kodama Y., Kogo Y., Kojima M., Kojima S., Komatsu N., Komiyama H., Kono T., Koseki H., Koyasu S., Kratz A., Kukalev A., Kulakovskiy I., Kundaje A., Kunikata H., Kuo R., Kuo T., Kuraku S., Kuznetsov V. A., Kwon T. J., Larouche M., Lassmann T., Law A., Le-Cao K. -A., Lecellier C. -H., Lee W., Lenhard B., Lennartsson A., Li K., Li R., Lilje B., Lipovich L., Lizio M., Lopez G., Magi S., Mak G. K., Makeev V., Manabe R., Mandai M., Mar J., Maruyama K., Maruyama T., Mason E., Mathelier A., Matsuda H., Medvedeva Y. A., Meehan T. F., Mejhert N., Meynert A., Mikami N., Minoda A., Miura H., Miyagi Y., Miyawaki A., Mizuno Y., Morikawa H., Morimoto M., Morioka M., Morishita S., Moro K., Motakis E., Motohashi H., Mukarram A. K., Mummery C. L., Mungall C. J., Murakawa Y., Muramatsu M., Nagasaka K., Nagase T., Nakachi Y., Nakahara F., Nakai K., Nakamura K., Nakamura Y., Nakazawa T., Nason G. P., Nepal C., Nguyen Q. H., Nielsen L. K., Nishida K., Nishiguchi K. M., Nishiyori H., Nitta K., Notredame C., Ogishima S., Ohkura N., Ohno H., Ohshima M., Ohtsu T., Okada Y., Okada-Hatakeyama M., Okazaki Y., Oksvold P., Orlando V., Ow G. S., Ozturk M., Pachkov M., Paparountas T., Parihar S. P., Park S. -J., Pascarella G., Passier R., Persson H., Philippens I. H., Piazza S., Plessy C., Pombo A., Ponten F., Poulain S., Poulsen T. M., Pradhan S., Prezioso C., Pridans C., Qin X. -Y., Quackenbush J., Rackham O., Ramilowski J., Ravasi T., Rehli M., Rennie S., Rito T., Rizzu P., Robert C., Roos M., Rost B., Roudnicky F., Roy R., Rye M. B., Sachenkova O., Saetrom P., Sai H., Saiki S., Saito M., Saito A., Sakaguchi S., Sakai M., Sakaue S., Sakaue-Sawano A., Sandelin A., Sano H., Sasamoto Y., Sato H., Saxena A., Saya H., Schafferhans A., Schmeier S., Schmidl C., Schmocker D., Schneider C., Schueler M., Schultes E. A., Schulze-Tanzil G., Semple C. A., Seno S., Seo W., Sese J., Sheng G., Shi J., Shimoni Y., Shin J. W., SimonSanchez J., Sivertsson A., Sjostedt E., Soderhall C., Laurent G. S., Stoiber M. H., Sugiyama D., Summers K. M., Suzuki A. M., Suzuki K., Suzuki M., Suzuki N., Suzuki T., Swanson D. J., Swoboda R. K., Taguchi A., Takahashi H., Takahashi M., Takamochi K., Takeda S., Takenaka Y., Tam K. T., Tanaka H., Tanaka R., Tanaka Y., Tang D., Taniuchi I., Tanzer A., Tarui H., Taylor M. S., Terada A., Terao Y., Testa A. C., Thomas M., Thongjuea S., Tomii K., Triglia E. T., Toyoda H., Tsang H. G., Tsujikawa M., Uhlen M., Valen E., van de Wetering M., van Nimwegen E., Velmeshev D., Verardo R., Vitezic M., Vitting-Seerup K., von Feilitzen K., Voolstra C. R., Vorontsov I. E., Wahlestedt C., Wasserman W. W., Watanabe K., Watanabe S., Wells C. A., Winteringham L. N., Wolvetang E., Yabukami H., Yagi K., Yamada T., Yamaguchi Y., Yamamoto M., Yamamoto Y., Yamanaka Y., Yano K., Yasuzawa K., Yatsuka Y., Yo M., Yokokura S., Yoneda M., Yoshida E., Yoshida Y., Yoshihara M., Young R., Young R. S., Yu N. Y., Yumoto N., Zabierowski S. E., Zhang P. G., Zucchelli S., Zwahlen M., Chatelain C., Brehelin L.

Publikováno v: Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, 2021, 12, pp.1-18/3297. ⟨10.1038/s41467-021-23143-7⟩
Nature communications, 12(1):3297. Nature Publishing Group
Nature Communications, Nature Publishing Group, 2021, 12, pp.1-18. ⟨10.1038/s41467-021-23143-7⟩
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Grapotte, M, Saraswat, M, Bessière, C, Menichelli, C, Ramilowski, J A, Severin, J, Hayashizaki, Y, Itoh, M, Tagami, M, Murata, M, Kojima-Ishiyama, M, Noma, S, Noguchi, S, Kasukawa, T, Hasegawa, A, Suzuki, H, Nishiyori-Sueki, H, Frith, M C, Abugessaisa, I, Aitken, S, Aken, B L, Alam, I, Alam, T, Alasiri, R, Alhendi, A M N, Alinejad-Rokny, H, Alvarez, M J, Andersson, R, Arakawa, T, Araki, M, Arbel, T, Bornholdt, J, Boyd, M, Chen, Y, Coskun, M, Dalby, M, Ienasescu, H, Jørgensen, M, Kaczkowski, B, Kere, J, Li, K, Lilje, B, Nepal, C, Nguyen, Q H, Nielsen, L K, Rennie, S, Sandelin, A, Valen, E, Vitezic, M, Vitting-Seerup, K & FANTOM Consortium 2021, ' Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network ', Nature Communications, vol. 12, 3297 . https://doi.org/10.1038/s41467-021-23143-7
Grapotte, Mathys; Saraswat, Manu; Bessière, Chloé; Menichelli, Christophe; Ramilowski, Jordan A; Severin, Jessica; Hayashizaki, Yoshihide; Itoh, Masayoshi; Tagami, Michihira; Murata, Mitsuyoshi; Kojima-Ishiyama, Miki; Noma, Shohei; Noguchi, Shuhei; Kasukawa, Takeya; Hasegawa, Akira; Suzuki, Harukazu; Nishiyori-Sueki, Hiromi; Frith, Martin C; Chatelain, Clément; Carninci, Piero; ... (2021). Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network. Nature communications, 12(1), p. 3297. Nature Publishing Group 10.1038/s41467-021-23143-7
Grapotte, M, Saraswat, M, Bessière, C, Menichelli, C, Ramilowski, J A, Severin, J, Hayashizaki, Y, Itoh, M, Tagami, M, Murata, M, Kojima-ishiyama, M, Noma, S, Noguchi, S, Kasukawa, T, Hasegawa, A, Suzuki, H, Nishiyori-sueki, H, Frith, M, Abugessaisa, I, Aitken, S, Aken, B L, Alam, I, Alam, T, Alasiri, R, Alhendi, A M N, Alinejad-rokny, H, Alvarez, M J, Andersson, R, Arakawa, T, Araki, M, Arbel, T, Archer, J, Archibald, A L, Arner, E, Arner, P, Asai, K, Ashoor, H, Astrom, G, Babina, M, Baillie, J K, Bajic, V B, Bajpai, A, Baker, S, Baldarelli, R M, Balic, A, Bansal, M, Batagov, A O, Batzoglou, S, Beckhouse, A G, Beltrami, A P, Beltrami, C A, Bertin, N, Bhattacharya, S, Bickel, P J, Blake, J A, Blanchette, M, Bodega, B, Bonetti, A, Bono, H, Bornholdt, J, Bttcher, M, Bougouffa, S, Boyd, M, Breda, J, Brombacher, F, Brown, J B, Bult, C J, Burroughs, A M, Burt, D W, Busch, A, Caglio, G, Califano, A, Cameron, C J, Cannistraci, C V, Carbone, A, Carlisle, A J, Carninci, P, Carter, K W, Cesselli, D, Chang, J, Chen, J C, Chen, Y, Chierici, M, Christodoulou, J, Ciani, Y, Clark, E L, Coskun, M, Dalby, M, Dalla, E, Daub, C O, Davis, C A, De Hoon, M J L, De Rie, D, Denisenko, E, Deplancke, B, Detmar, M, Deviatiiarov, R, Di Bernardo, D, Diehl, A D, Dieterich, L C, Dimont, E, Djebali, S, Dohi, T, Dostie, J, Drablos, F, Edge, A S B, Edinger, M, Ehrlund, A, Ekwall, K, Elofsson, A, Endoh, M, Enomoto, H, Enomoto, S, Faghihi, M, Fagiolini, M, Farach-carson, M C, Faulkner, G J, Favorov, A, Fernandes, A M, Ferrai, C, Forrest, A R R, Forrester, L M, Forsberg, M, Fort, A, Francescatto, M, Freeman, T C, Frith, M, Fukuda, S, Funayama, M, Furlanello, C, Furuno, M, Furusawa, C, Gao, H, Gazova, I, Gebhard, C, Geier, F, Geijtenbeek, T B H, Ghosh, S, Ghosheh, Y, Gingeras, T R, Gojobori, T, Goldberg, T, Goldowitz, D, Gough, J, Greco, D, Gruber, A J, Guhl, S, Guigo, R, Guler, R, Gusev, O, Gustincich, S, Ha, T J, Haberle, V, Hale, P, Hallstrom, B M, Hamada, M, Handoko, L, Hara, M, Harbers, M, Harrow, J, Harshbarger, J, Hase, T, Hasegawa, A, Hashimoto, K, Hatano, T, Hattori, N, Hayashi, R, Hayashizaki, Y, Herlyn, M, Hettne, K, Heutink, P, Hide, W, Hitchens, K J, Sui, S H, ’t Hoen, P A C, Hon, C C, Hori, F, Horie, M, Horimoto, K, Horton, P, Hou, R, Huang, E, Huang, Y, Hugues, R, Hume, D, Ienasescu, H, Iida, K, Ikawa, T, Ikemura, T, Ikeo, K, Inoue, N, Ishizu, Y, Ito, Y, Itoh, M, Ivshina, A V, Jankovic, B R, Jenjaroenpun, P, Johnson, R, Jorgensen, M, Jorjani, H, Joshi, A, Jurman, G, Kaczkowski, B, Kai, C, Kaida, K, Kajiyama, K, Kaliyaperumal, R, Kaminuma, E, Kanaya, T, Kaneda, H, Kapranov, P, Kasianov, A S, Kasukawa, T, Katayama, T, Kato, S, Kawaguchi, S, Kawai, J, Kawaji, H, Kawamoto, H, Kawamura, Y I, Kawasaki, S, Kawashima, T, Kempfle, J S, Kenna, T J, Kere, J, Khachigian, L, Kiryu, H, Kishima, M, Kitajima, H, Kitamura, T, Kitano, H, Klaric, E, Klepper, K, Klinken, S P, Kloppmann, E, Knox, A J, Kodama, Y, Kogo, Y, Kojima, M, Kojima, S, Komatsu, N, Komiyama, H, Kono, T, Koseki, H, Koyasu, S, Kratz, A, Kukalev, A, Kulakovskiy, I, Kundaje, A, Kunikata, H, Kuo, R, Kuo, T, Kuraku, S, Kuznetsov, V A, Kwon, T J, Larouche, M, Lassmann, T, Law, A, Le-cao, K, Lecellier, C, Lee, W, Lenhard, B, Lennartsson, A, Li, K, Li, R, Lilje, B, Lipovich, L, Lizio, M, Lopez, G, Magi, S, Mak, G K, Makeev, V, Manabe, R, Mandai, M, Mar, J, Maruyama, K, Maruyama, T, Mason, E, Mathelier, A, Matsuda, H, Medvedeva, Y A, Meehan, T F, Mejhert, N, Meynert, A, Mikami, N, Minoda, A, Miura, H, Miyagi, Y, Miyawaki, A, Mizuno, Y, Morikawa, H, Morimoto, M, Morioka, M, Morishita, S, Moro, K, Motakis, E, Motohashi, H, Mukarram, A K, Mummery, C L, Mungall, C J, Murakawa, Y, Muramatsu, M, Murata, M, Nagasaka, K, Nagase, T, Nakachi, Y, Nakahara, F, Nakai, K, Nakamura, K, Nakamura, Y, Nakamura, Y, Nakazawa, T, Nason, G P, Nepal, C, Nguyen, Q H, Nielsen, L K, Nishida, K, Nishiguchi, K M, Nishiyori, H, Nitta, K, Noguchi, S, Noma, S, Notredame, C, Ogishima, S, Ohkura, N, Ohno, H, Ohshima, M, Ohtsu, T, Okada, Y, Okada-hatakeyama, M, Okazaki, Y, Oksvold, P, Orlando, V, Ow, G S, Ozturk, M, Pachkov, M, Paparountas, T, Parihar, S P, Park, S, Pascarella, G, Passier, R, Persson, H, Philippens, I H, Piazza, S, Plessy, C, Pombo, A, Ponten, F, Poulain, S, Poulsen, T M, Pradhan, S, Prezioso, C, Pridans, C, Qin, X, Quackenbush, J, Rackham, O, Ramilowski, J, Ravasi, T, Rehli, M, Rennie, S, Rito, T, Rizzu, P, Robert, C, Roos, M, Rost, B, Roudnicky, F, Roy, R, Rye, M B, Sachenkova, O, Saetrom, P, Sai, H, Saiki, S, Saito, M, Saito, A, Sakaguchi, S, Sakai, M, Sakaue, S, Sakaue-sawano, A, Sandelin, A, Sano, H, Sasamoto, Y, Sato, H, Saxena, A, Saya, H, Schafferhans, A, Schmeier, S, Schmidl, C, Schmocker, D, Schneider, C, Schueler, M, Schultes, E A, Schulze-tanzil, G, Semple, C A, Seno, S, Seo, W, Sese, J, Severin, J, Sheng, G, Shi, J, Shimoni, Y, Shin, J W, Simonsanchez, J, Sivertsson, A, Sjostedt, E, Soderhall, C, Laurent, G S, Stoiber, M H, Sugiyama, D, Summers, K M, Suzuki, A M, Suzuki, H, Suzuki, K, Suzuki, M, Suzuki, N, Suzuki, T, Swanson, D J, Swoboda, R K, Tagami, M, Taguchi, A, Takahashi, H, Takahashi, M, Takamochi, K, Takeda, S, Takenaka, Y, Tam, K T, Tanaka, H, Tanaka, R, Tanaka, Y, Tang, D, Taniuchi, I, Tanzer, A, Tarui, H, Taylor, M S, Terada, A, Terao, Y, Testa, A C, Thomas, M, Thongjuea, S, Tomii, K, Triglia, E T, Toyoda, H, Tsang, H G, Tsujikawa, M, Uhlén, M, Valen, E, Van De Wetering, M, Van Nimwegen, E, Velmeshev, D, Verardo, R, Vitezic, M, Vitting-seerup, K, Von Feilitzen, K, Voolstra, C R, Vorontsov, I E, Wahlestedt, C, Wasserman, W W, Watanabe, K, Watanabe, S, Wells, C A, Winteringham, L N, Wolvetang, E, Yabukami, H, Yagi, K, Yamada, T, Yamaguchi, Y, Yamamoto, M, Yamamoto, Y, Yamamoto, Y, Yamanaka, Y, Yano, K, Yasuzawa, K, Yatsuka, Y, Yo, M, Yokokura, S, Yoneda, M, Yoshida, E, Yoshida, Y, Yoshihara, M, Young, R, Young, R S, Yu, N Y, Yumoto, N, Zabierowski, S E, Zhang, P G, Zucchelli, S, Zwahlen, M, Chatelain, C, Carninci, P, De Hoon, M J L, Wasserman, W W, Bréhélin, L & Lecellier, C 2021, ' Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network ', Nature Communications, vol. 12, no. 1 . https://doi.org/10.1038/s41467-021-23143-7
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-23143-7⟩
Nature Communications, 12 (1)

Using the Cap Analysis of Gene Expression (CAGE) technology, the FANTOM5 consortium provided one of the most comprehensive maps of transcription start sites (TSSs) in several species. Strikingly, ~72% of them could not be assigned to a specific gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071cc9b35fa8ab5830f24ee8cb404eaf
https://pubmed.ncbi.nlm.nih.gov/35232988

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ADRIATIC: A Phase III Study with Durvalumab plus /- Tremelimumab after concurrent Radiochemotherapy for Patients with SCLC in Stage Limited Disease

Autor: Raub, M., Senan, S., Okamoto, I, Lee, G-W, Yao, W., Mak, G., Shire, N., Jiang, H., Griesinger, F.

Publikováno v: Raub, M, Senan, S, Okamoto, I, Lee, G-W, Yao, W, Mak, G, Shire, N, Jiang, H & Griesinger, F 2020, ' ADRIATIC: A Phase III Study with Durvalumab plus /-Tremelimumab after concurrent Radiochemotherapy for Patients with SCLC in Stage Limited Disease ', Strahlentherapie und Onkologie, vol. 196, no. SUPPL 1, pp. S87-S87 .
Strahlentherapie und Onkologie, 196(SUPPL 1), S87-S87. Urban und Vogel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::11c06934c88a2aabadf350ad05c87745
https://research.vumc.nl/en/publications/33b81e8e-1d26-47ea-810d-b535b2d5d8c9

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Autor: Griesinger, F., Senan, S., Shire, N., Mak, G., Yao, W., Jiang, H., Thomas, M.

Publikováno v: ONCOLOGY RESEARCH AND TREATMENT, 43, 124-124. S. Karger AG
Griesinger, F, Senan, S, Shire, N, Mak, G, Yao, W, Jiang, H & Thomas, M 2020, ' Adriatic: a Phase III Trial of Durvalumab plus /-Tremelimumab After Concurrent Chemoradiation for Patients with Limited Stage Small Cell Lung Cancer ', ONCOLOGY RESEARCH AND TREATMENT, vol. 43, pp. 124-124 .

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https://research.vumc.nl/en/publications/e794148a-7a4e-4926-8bd1-8979da95501b

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