Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mak, Angel CY"'
Autor:
Joo, Jaehyun, Mak, Angel CY, Xiao, Shujie, Sleiman, Patrick M, Hu, Donglei, Huntsman, Scott, Eng, Celeste, Kan, Mengyuan, Diwakar, Avantika R, Lasky-Su, Jessica A, Weiss, Scott T, Sordillo, Joanne E, Wu, Ann C, Cloutier, Michelle, Canino, Glorisa, Forno, Erick, Celedón, Juan C, Seibold, Max A, Hakonarson, Hakon, Williams, L Keoki, Burchard, Esteban G, Himes, Blanca E
Publikováno v:
Scientific reports, vol 12, iss 1
Variability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator response (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::9a57f325672b9506d4543a4503bc8c6c
https://escholarship.org/uc/item/4vc0j9nr
https://escholarship.org/uc/item/4vc0j9nr
Autor:
Sajuthi, Satria P, Everman, Jamie L, Jackson, Nathan D, Saef, Benjamin, Rios, Cydney L, Moore, Camille M, Mak, Angel CY, Eng, Celeste, Fairbanks-Mahnke, Ana, Salazar, Sandra, Elhawary, Jennifer, Huntsman, Scott, Medina, Vivian, Nickerson, Deborah A, Germer, Soren, Zody, Michael C, Abecasis, Gonçalo, Kang, Hyun Min, Rice, Kenneth M, Kumar, Rajesh, Zaitlen, Noah A, Oh, Sam, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Rodríguez-Santana, José, Burchard, Esteban G, Seibold, Max A
Publikováno v:
Nature communications, vol 13, iss 1
To identify genetic determinants of airway dysfunction, we performed a transcriptome-wide association study for asthma by combining RNA-seq data from the nasal airway epithelium of 681 children, with UK Biobank genetic association data. Our airway an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::8062f69f333e27f4c2550fef7b18b8db
https://escholarship.org/uc/item/9vr9v3mj
https://escholarship.org/uc/item/9vr9v3mj
Autor:
Castellanos, Carlos A, Ren, Xin, Gonzalez, Steven Lomeli, Li, Hong Kun, Schroeder, Andrew W, Liang, Hong-Erh, Laidlaw, Brian J, Hu, Donglei, Mak, Angel CY, Eng, Celeste, Rodríguez-Santana, José R, LeNoir, Michael, Yan, Qi, Celedón, Juan C, Burchard, Esteban G, Zamvil, Scott S, Ishido, Satoshi, Locksley, Richard M, Cyster, Jason G, Huang, Xiaozhu, Shin, Jeoung-Sook
Publikováno v:
Science immunology, vol 6, iss 64
Type 2 T helper (TH2) cells are protective against parasitic worm infections but also aggravate allergic inflammation. Although the role of dendritic cells (DCs) in TH2 cell differentiation is well established, the underlying mechanisms are largely u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::aa5afe790f8e9e5588753537bb7490aa
https://escholarship.org/uc/item/11x9g083
https://escholarship.org/uc/item/11x9g083
Autor:
Kwong, Alan M, Blackwell, Thomas W, LeFaive, Jonathon, de Andrade, Mariza, Barnard, John, Barnes, Kathleen C, Blangero, John, Boerwinkle, Eric, Burchard, Esteban G, Cade, Brian E, Chasman, Daniel I, Chen, Han, Conomos, Matthew P, Cupples, L Adrienne, Ellinor, Patrick T, Eng, Celeste, Gao, Yan, Guo, Xiuqing, Irvin, Marguerite Ryan, Kelly, Tanika N, Kim, Wonji, Kooperberg, Charles, Lubitz, Steven A, Mak, Angel CY, Manichaikul, Ani W, Mathias, Rasika A, Montasser, May E, Montgomery, Courtney G, Musani, Solomon, Palmer, Nicholette D, Peloso, Gina M, Qiao, Dandi, Reiner, Alexander P, Roden, Dan M, Shoemaker, M Benjamin, Smith, Jennifer A, Smith, Nicholas L, Su, Jessica Lasky, Tiwari, Hemant K, Weeks, Daniel E, Weiss, Scott T, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Analysis Working Group, Scott, Laura J, Smith, Albert V, Abecasis, Gonçalo R, Boehnke, Michael, Kang, Hyun Min
Publikováno v:
Genetics, vol 218, iss 1
Traditional Hardy-Weinberg equilibrium (HWE) tests (the χ2 test and the exact test) have long been used as a metric for evaluating genotype quality, as technical artifacts leading to incorrect genotype calls often can be identified as deviations fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::79667fae3bb7bad2ed499ebcd5540230
https://escholarship.org/uc/item/7607p308
https://escholarship.org/uc/item/7607p308
Autor:
Goddard, Pagé C, Keys, Kevin L, Mak, Angel CY, Lee, Eunice Y, Liu, Amy K, Samedy-Bates, Lesly-Anne, Risse-Adams, Oona, Contreras, María G, Elhawary, Jennifer R, Hu, Donglei, Huntsman, Scott, Oh, Sam S, Salazar, Sandra, Eng, Celeste, Himes, Blanca E, White, Marquitta J, Burchard, Esteban G
Publikováno v:
Genetic epidemiology, vol 45, iss 2
Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung function present with diseases such as asthma. Administration of BD medication can partially or fully restore lung function as measured by pulmonary fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::1fe64c016abac63703a7398631c45527
https://escholarship.org/uc/item/21z6g5nq
https://escholarship.org/uc/item/21z6g5nq
Autor:
Herrera-Luis, Esther, Espuela-Ortiz, Antonio, Lorenzo-Diaz, Fabian, Keys, Kevin L, Mak, Angel CY, Eng, Celeste, Huntsman, Scott, Villar, Jesús, Rodriguez-Santana, Jose R, Burchard, Esteban G, Pino-Yanes, Maria
Publikováno v:
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, vol 32, iss 1
BackgroundSevere asthma exacerbations are a major cause of asthma morbidity and increased healthcare costs. Several studies have shown racial and ethnic differences in asthma exacerbation rates. We aimed to identify genetic variants associated with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::15ccb8e1b0855821daa23633188576cd
https://escholarship.org/uc/item/7k6854rg
https://escholarship.org/uc/item/7k6854rg
Autor:
Bick, Alexander G, Weinstock, Joshua S, Nandakumar, Satish K, Fulco, Charles P, Bao, Erik L, Zekavat, Seyedeh M, Szeto, Mindy D, Liao, Xiaotian, Leventhal, Matthew J, Nasser, Joseph, Chang, Kyle, Laurie, Cecelia, Burugula, Bala Bharathi, Gibson, Christopher J, Lin, Amy E, Taub, Margaret A, Aguet, Francois, Ardlie, Kristin, Mitchell, Braxton D, Barnes, Kathleen C, Moscati, Arden, Fornage, Myriam, Redline, Susan, Psaty, Bruce M, Silverman, Edwin K, Weiss, Scott T, Palmer, Nicholette D, Vasan, Ramachandran S, Burchard, Esteban G, Kardia, Sharon LR, He, Jiang, Kaplan, Robert C, Smith, Nicholas L, Arnett, Donna K, Schwartz, David A, Correa, Adolfo, de Andrade, Mariza, Guo, Xiuqing, Konkle, Barbara A, Custer, Brian, Peralta, Juan M, Gui, Hongsheng, Meyers, Deborah A, McGarvey, Stephen T, Chen, Ida Yii-Der, Shoemaker, M Benjamin, Peyser, Patricia A, Broome, Jai G, Gogarten, Stephanie M, Wang, Fei Fei, Wong, Quenna, Montasser, May E, Daya, Michelle, Kenny, Eimear E, North, Kari E, Launer, Lenore J, Cade, Brian E, Bis, Joshua C, Cho, Michael H, Lasky-Su, Jessica, Bowden, Donald W, Cupples, L Adrienne, Mak, Angel CY, Becker, Lewis C, Smith, Jennifer A, Kelly, Tanika N, Aslibekyan, Stella, Heckbert, Susan R, Tiwari, Hemant K, Yang, Ivana V, Heit, John A, Lubitz, Steven A, Johnsen, Jill M, Curran, Joanne E, Wenzel, Sally E, Weeks, Daniel E, Rao, Dabeeru C, Darbar, Dawood, Moon, Jee-Young, Tracy, Russell P, Buth, Erin J, Rafaels, Nicholas, Loos, Ruth JF, Durda, Peter, Liu, Yongmei, Hou, Lifang, Lee, Jiwon, Kachroo, Priyadarshini, Freedman, Barry I, Levy, Daniel, Bielak, Lawrence F, Hixson, James E, Floyd, James S, Whitsel, Eric A, Ellinor, Patrick T, Irvin, Marguerite R, Fingerlin, Tasha E, Raffield, Laura M, Armasu, Sebastian M, Wheeler, Marsha M
Publikováno v:
Nature, vol 586, iss 7831
Age is the dominant risk factor for most chronic human diseases, but the mechanisms through which ageing confers this risk are largely unknown1. The age-related acquisition of somatic mutations that lead to clonal expansion in regenerating haematopoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7a0a8f97539e2476439614239fdd3d58
https://escholarship.org/uc/item/7w16b34n
https://escholarship.org/uc/item/7w16b34n
Autor:
Kachroo, Priyadarshini, Hecker, Julian, Chawes, Bo L, Ahluwalia, Tarunveer S, Cho, Michael H, Qiao, Dandi, Kelly, Rachel S, Chu, Su H, Virkud, Yamini V, Huang, Mengna, Barnes, Kathleen C, Burchard, Esteban G, Eng, Celeste, Hu, Donglei, Celedón, Juan C, Daya, Michelle, Levin, Albert M, Gui, Hongsheng, Williams, L Keoki, Forno, Erick, Mak, Angel CY, Avila, Lydiana, Soto-Quiros, Manuel E, Cloutier, Michelle M, Acosta-Pérez, Edna, Canino, Glorisa, Bønnelykke, Klaus, Bisgaard, Hans, Raby, Benjamin A, Lange, Christoph, Weiss, Scott T, Lasky-Su, Jessica A, National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) Consortium
Publikováno v:
Chest, vol 156, iss 6
BackgroundAsthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::0381a72d3f90c0d778febeca2923744b
https://escholarship.org/uc/item/9m92f03v
https://escholarship.org/uc/item/9m92f03v
Autor:
Taub, Margaret A, Weinstock, Joshua S, Iyer, Kruthika R, Yanek, Lisa R, Conomos, Matthew P, Brody, Jennifer A, Keramati, Ali, Laurie, Cecelia A, Arvanitis, Marios, Smith, Albert V, Lane, John, Becker, Lewis C, Bis, Joshua C, Blangero, John, Bleecker, Eugene R, Burchard, Esteban G, Celedon, Juan C, Chang, Yen Pei C, Custer, Brian, Darbar, Dawood, de las Fuentes, Lisa, DeMeo, Dawn L, Freedman, Barry I, Garrett, Melanie E, Gladwin, Mark T, Heckbert, Susan R, Hidalgo, Bertha A, Ingram, Christie, Irvin, Marguerite R, Craig Johnson, W, Kaab, Stefan, Launer, Lenore, Lee, Jiwon, Liu, Simin, Moscati, Arden, North, Kari E, Peyser, Patricia A, Rafaels, Nicholas, Raffield, Laura M, Weeks, Daniel E, Wheeler, Marsha M, Keoki Williams, L., Zhao, Wei, Armanios, Mary, Aslibekyan, Stella, Auer, Paul L, Bowden, Donald W, Cade, Brian E, Yii-Der Chen, Ida, Cho, Michael H, Cupples, L Adrienne, Curran, Joanne E, Daya, Michelle, Deka, Ranjan, Guo, Xiuqing, Hou, Lifang, Hwang, Shih-Jen, Johnsen, Jill M, Kenny, Eimear E, Levin, Albert M, Liu, Chunyu, Minster, Ryan L, Nouraie, Mehdi, Sabino, Ester C, Smith, Jennifer A, Smith, Nicholas L, Lasky Su, Jessica, Telen, Marilyn J, Tiwari, Hemant K, Tracy, Russell P, White, Marquitta J, Zhang, Yingze, Wiggins, Kerri L, Weiss, Scott T, Vasan, Ramachandran S, Taylor, Kent D, Sinner, Moritz F, Silverman, Edwin K, Benjamin Shoemaker, M., Sheu, Wayne H-H, Rotter, Jerome I, Redline, Susan, Psaty, Bruce M, Peralta, Juan M, Palmer, Nicholette D, Loos, Ruth JF, Montgomery, Courtney G, Mitchell, Braxton D, Meyers, Deborah A, McGarvey, Stephen T, Mak, Angel CY, Kumar, Rajesh, Kooperberg, Charles, Konkle, Barbara A, Kelly, Shannon, Kardia, Sharon LR, Kaplan, Robert, He, Jiang, Gui, Hongsheng, Fornage, Myriam, Ellinor, Patrick T, de Andrade, Mariza, Correa, Adolfo, Boerwinkle, Eric, Barnes, Kathleen C, Ashley-Koch, Allison E, Arnett, Donna K, Albert, Christine, Laurie, Cathy C, Abecasis, Goncalo, Aviv, Abraham, Nickerson, Deborah A, Wilson, James G, Rich, Stephen S, Levy, Daniel, Battle, Alexis, Blackwell, Thomas W, Ruczinski, Ingo, Thornton, Timothy, O’Connell, Jeff, Perry, James A, Pankratz, Nathan, Reiner, Alexander P, Mathias, Rasika A
Telomeres shorten in replicating somatic cells and with age; in human leukocytes, telomere length (TL) is associated with a host of aging-related diseases 1,2 . To date, 16 genome-wide association studies (GWAS) have identified twenty-three loci asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::1db37bd314f472279a28acdb4ce1d072
Autor:
Mak, Angel CY, White, Marquitta J, Eckalbar, Walter L, Szpiech, Zachary A, Oh, Sam S, Pino-Yanes, Maria, Hu, Donglei, Goddard, Pagé, Huntsman, Scott, Galanter, Joshua, Wu, Ann Chen, Himes, Blanca E, Germer, Soren, Vogel, Julia M, Bunting, Karen L, Eng, Celeste, Salazar, Sandra, Keys, Kevin L, Liberto, Jennifer, Nuckton, Thomas J, Nguyen, Thomas A, Torgerson, Dara G, Kwok, Pui-Yan, Levin, Albert M, Celedón, Juan C, Forno, Erick, Hakonarson, Hakon, Sleiman, Patrick M, Dahlin, Amber, Tantisira, Kelan G, Weiss, Scott T, Serebrisky, Denise, Brigino-Buenaventura, Emerita, Farber, Harold J, Meade, Kelley, Lenoir, Michael A, Avila, Pedro C, Sen, Saunak, Thyne, Shannon M, Rodriguez-Cintron, William, Winkler, Cheryl A, Moreno-Estrada, Andrés, Sandoval, Karla, Rodriguez-Santana, Jose R, Kumar, Rajesh, Williams, L Keoki, Ahituv, Nadav, Ziv, Elad, Seibold, Max A, Darnell, Robert B, Zaitlen, Noah, Hernandez, Ryan D, Burchard, Esteban G, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
Publikováno v:
American journal of respiratory and critical care medicine, vol 197, iss 12
RationaleAlbuterol, a bronchodilator medication, is the first-line therapy for asthma worldwide. There are significant racial/ethnic differences in albuterol drug response.ObjectivesTo identify genetic variants important for bronchodilator drug respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::ae26c7c2db924a9f6a9a29317af7a753
https://escholarship.org/uc/item/4j38w0kn
https://escholarship.org/uc/item/4j38w0kn