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Akademický článek

Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes

Autor: Elise Ishida, Devin T. Corrigan, Ryan J. Malonis, Daniel Hofmann, Tingting Chen, Anita G. Amin, Delphi Chatterjee, Maju Joe, Todd L. Lowary, Jonathan R. Lai, Jacqueline M. Achkar

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)

Elise Ishida et al. generate human monoclonal antibodies that can selectively recognize specific oligosaccharide epitopes of the polysaccharides arabinomannan and lipoarabinomannan, which are critical for M. tuberculosis pathogenesis. The authors dem

Externí odkaz: https://doaj.org/article/beed135280764d7ba72204f728213be0

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Akademický článek

The singular Corynebacterium glutamicum Emb arabinofuranosyltransferase polymerises the α(1 → 5) arabinan backbone in the early stages of cell wall arabinan biosynthesis

Autor: Monika Jankute, Luke J. Alderwick, Alice R. Moorey, Maju Joe, Sudagar S. Gurcha, Lothar Eggeling, Todd L. Lowary, Anne Dell, Poh-Choo Pang, Tiandi Yang, Stuart Haslam, Gurdyal S. Besra

Publikováno v: The Cell Surface, Vol 2, Iss , Pp 38-53 (2018)

The arabinan-containing polysaccharides, arabinogalactan (AG) and lipoarabinomannan (LAM), are key cell wall components of the Corynebacterineae, which include Corynebacteria, Norcadia and Mycobacteria. Both AG and LAM contain elaborate arabinan doma

Externí odkaz: https://doaj.org/article/878dde211947413aaeecc3de06b0131f

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Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes

Autor: Delphi Chatterjee, Tingting Chen, Todd L. Lowary, Jacqueline M. Achkar, Devin T. Corrigan, Anita G. Amin, Jonathan R. Lai, Maju Joe, Elise Ishida, Ryan J. Malonis, Daniel Hofmann

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology

The surface polysacharide arabinomannan (AM) and related glycolipid lipoarabinomannan (LAM) play critical roles in tuberculosis pathogenesis. Human antibody responses to AM/LAM are heterogenous and knowledge of reactivity to specific glycan epitopes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd27b5f925e0204cf11d1f92e7545f7a
https://doaj.org/article/beed135280764d7ba72204f728213be0

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Akademický článek

Enhanced control of Mycobacterium tuberculosis extrapulmonary dissemination in mice by an arabinomannan-protein conjugate vaccine.

Publikováno v: PLoS Pathogens, Vol 13, Iss 3, p e1006250 (2017)

Currently there are a dozen or so of new vaccine candidates in clinical trials for prevention of tuberculosis (TB) and each formulation attempts to elicit protection by enhancement of cell-mediated immunity (CMI). In contrast, most approved vaccines

Externí odkaz: https://doaj.org/article/05a00e1f415147c2a37c636bd2ccbc98

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Akademický článek

Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis

Autor: James Harrison, Georgina Lloyd, Maju Joe, Todd L. Lowary, Edward Reynolds, Hannah Walters-Morgan, Apoorva Bhatt, Andrew Lovering, Gurdyal S. Besra, Luke J. Alderwick

Publikováno v: mBio, Vol 7, Iss 4 (2016)

ABSTRACT Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), has a unique cell envelope which accounts for its unusual low permeability and contributes to resistance against common antibiotics. The main structural elements of the

Externí odkaz: https://doaj.org/article/a3223e2e64154308893256d5b2e5c943

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Use of Synthetic Glycolipids to Probe the Number and Position of Arabinan Chains on Mycobacterial Arabinogalactan

Autor: Avraham Liav, Michael R. McNeil, Todd L. Lowary, Shiva K. Angala, Maju Joe, Mary Jackson

Publikováno v: ACS Chem Biol

The arabinogalactan of Corynebacterianeae is a critical heteropolysaccharide that tethers outer membrane mycolic acids to peptidoglycan thus forming the characteristic cell wall core of these prokaryotes. An essential α-(1→5)-arabinosyltransferase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe4a441ac0017a938b49f711214f1e2
https://doi.org/10.1021/acschembio.0c00765

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The endogenous galactofuranosidase GlfH1 hydrolyzes mycobacterial arabinogalactan

Autor: Albertus Viljoen, Yann Guérardel, Alexandre Mery, Maju Joe, Laurent Kremer, Sydney A. Villaume, Emeline Fabre, Christophe Mariller, Kaoru Takegawa, Stéphane P. Vincent, Lin Shen, Todd L. Lowary, Iman Halloum, Loïc P. Chêne

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, pp.jbc.RA119.011817. ⟨10.1074/jbc.RA119.011817⟩
Journal of Biological Chemistry, 2020, pp.jbc.RA119.011817. ⟨10.1074/jbc.RA119.011817⟩
J Biol Chem

International audience; Despite the impressive progress made over the past 20 years in our understanding of mycolylarabinogalactan-peptidoglycan (mAGP) biogenesis, the mechanisms by which the tubercle bacillus Mycobacterium tuberculosis adapts its ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7361d37d2cf244f15dd89992dd74da90
https://researchportal.unamur.be/en/publications/96382eac-e4aa-4c2f-bf9c-198dca7ca6f5

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