Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Major Technical Advances"'
Autor:
Kewal Asosingh, Matthew Frimel, Violetta Zlojutro, Dillon Grant, Olivia Stephens, David Wenger, Andreas Fouras, Frank DiFilippo, Serpil Erzurum
Publikováno v:
Am J Respir Cell Mol Biol
The current standard for lung function evaluation in murine models is based on forced oscillation technology, which provides a measure of the total airway function but cannot provide information on regional heterogeneity in function. Limited detectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9952e2371a8d69e90dbc8287371044f8
https://europepmc.org/articles/PMC9564925/
https://europepmc.org/articles/PMC9564925/
Publikováno v:
Am J Respir Cell Mol Biol
Type II alveolar epithelial cells (AEC2s) play an essential role in the function and maintenance of the pulmonary epithelium. Several transgenic mice have been developed to study the function of these cells in vivo by using the human SFTPC promoter t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5105e57271f895cae3f617f236c5f32f
https://doi.org/10.1165/rcmb.2019-0416ma
https://doi.org/10.1165/rcmb.2019-0416ma
Autor:
Mallory L. Lennon, Jeffrey G. Jacot, Anne C. Lyons, Chelsea M. Magin, Christopher Pino, Steven R. Lammers, Kolene E. Bailey, Melanie Königshoff
Publikováno v:
Am J Respir Cell Mol Biol
Maintaining the three-dimensional architecture and cellular complexity of lung tissue ex vivo can enable elucidation of the cellular and molecular pathways underlying chronic pulmonary diseases. Precision-cut lung slices (PCLS) are one human-lung mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1945fb2d7871071d478a1961b8c35bc2
https://doi.org/10.1165/rcmb.2019-0232ma
https://doi.org/10.1165/rcmb.2019-0232ma
Autor:
Ali N. Bahadur, Bart P. Black, David A. Lynch, Elizabeth F. Redente, David W. H. Riches, Rachel L. Zemans, Stephen M. Humphries, Donald S. Backos, Rubin M. Tuder
Publikováno v:
Am J Respir Cell Mol Biol
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic interstitial lung disease with underlying mechanisms that have been primarily investigated in mice after intratracheal instillation of a single dose of bleomycin. However, the model has si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1715ca01e8a26116a44cfb26d6af803
https://pubmed.ncbi.nlm.nih.gov/33406369
https://pubmed.ncbi.nlm.nih.gov/33406369
Publikováno v:
Am J Respir Cell Mol Biol
Single-cell RNA sequencing (scRNASeq) has advanced our understanding of lung biology, but its utility is limited by the need for fresh samples, loss of cell types by death or inadequate dissociation, and transcriptional stress responses induced durin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576ce4ecb8e9b465ae71ae71a56ce469
https://europepmc.org/articles/PMC7790136/
https://europepmc.org/articles/PMC7790136/
Autor:
Walter E. Finkbeiner, Walter L. Eckalbar, Dingyuan I Sun, Leqian Liu, David J. Erle, Dan Cheng, Lorna T Zlock, Kristina Johansson, Luke R. Bonser, Kyung Duk Koh, Semil P. Choksi
Publikováno v:
Am J Respir Cell Mol Biol
The human airway epithelium is essential in homeostasis, and epithelial dysfunction contributes to chronic airway disease. Development of flow-cytometric methods to characterize subsets of airway epithelial cells will enable further dissection of air
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b496e4a8ae8241cb1083bd0538e52ca3
https://pubmed.ncbi.nlm.nih.gov/33196316
https://pubmed.ncbi.nlm.nih.gov/33196316
Autor:
Jennifer A, Wambach, Ping, Yang, Daniel J, Wegner, Hillary B, Heins, Cliff, Luke, Fuhai, Li, Frances V, White, F Sessions, Cole
Publikováno v:
Am J Respir Cell Mol Biol
Rare or private, biallelic variants in the ABCA3 (ATP-binding cassette transporter A3) gene are the most common monogenic cause of lethal neonatal respiratory failure and childhood interstitial lung disease. Functional characterization of fewer than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::534c9137b70835df72fb86c2e42d1885
https://pubmed.ncbi.nlm.nih.gov/32692933
https://pubmed.ncbi.nlm.nih.gov/32692933
Autor:
John T. Benjamin, Seunghyi Kook, Linda A. Gleaves, Adel Eskaros, Janice A. Williams, Laura Goetzl, Jonathan A. Kropski, Susan H. Guttentag, Christopher S. Jetter, Timothy S. Blackwell, Holli A. Loomans, Lisa R. Young, Andries Zijlstra, Erin J. Plosa, Carla L. Calvi, Jennifer M.S. Sucre, Ping Wang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 59:158-166
Alveolar type II (AT2) epithelial cells are uniquely specialized to produce surfactant in the lung and act as progenitor cells in the process of repair after lung injury. AT2 cell injury has been implicated in several lung diseases, including idiopat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680a94874935ff7140af387b97757547
https://doi.org/10.1165/rcmb.2017-0442ma
https://doi.org/10.1165/rcmb.2017-0442ma
Autor:
Ping Wang, Susan H. Guttentag, Shufang Meng, Seunghyi Kook, Peter M. Gulleman, Aidong Qi, Lisa R. Young
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 58:566-574
Defining the mechanisms of cellular pathogenesis in rare lung diseases such as Hermansky-Pudlak syndrome (HPS) is often complicated by loss of the differentiated phenotype of cultured primary alveolar type 2 (AT2) cells, as well as by a lack of durab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0709820b4ddcc0f8b4b21e7d9bc0c729
https://doi.org/10.1165/rcmb.2017-0324ma
https://doi.org/10.1165/rcmb.2017-0324ma
Autor:
Jazalle McClendon, Rubin M. Tuder, Nicole L. Jansing, Peter M. Henson, Dallas M. Hyde, Rachel L. Zemans
Publikováno v:
American journal of respiratory cell and molecular biology, vol 57, iss 5
The alveolar epithelium consists of squamous alveolar type (AT) I and cuboidal ATII cells. ATI cells cover 95-98% of the alveolar surface, thereby playing a critical role in barrier integrity, and are extremely thin, thus permitting efficient gas exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9760a188c16e6145ce5bc708acbdf413
https://doi.org/10.1165/rcmb.2017-0037ma
https://doi.org/10.1165/rcmb.2017-0037ma