Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Majken Westergaard"'
Autor:
Charlotte Albæk, Majken Westergaard, Puja Sapra, Henrik Ørum, Henrik Daa Schrøder, Henrik Frydenlund, Lee M. Greenberger, Ivan Horak, David Filpula
Publikováno v:
Greenberger, L M, Horak, I D, Filpula, D, Sapra, P, Westergaard, M, Frydenlund, H F, Albaek, C, Schrøder, H & Ørum, H 2008, ' A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth ', Molecular Cancer Therapeutics, vol. 7, no. 11, pp. 3598-608 . https://doi.org/10.1158/1535-7163.MCT-08-0510
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays a critical role in angiogenesis, survival, metastasis, drug resistance, and glucose metabolism. Elevated expression of the α-subunit of HIF-1 (HIF-1α), which occurs in response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96ada4f50e32d24b9b262f65b8f9b16c
https://doi.org/10.1158/1535-7163.mct-08-0510
https://doi.org/10.1158/1535-7163.mct-08-0510
Autor:
Claus Johansen, Lars Iversen, Majken Westergaard, Karsten Kristiansen, Knud Kragballe, Jeanette Henningsen, Esben N. Flindt
Publikováno v:
Journal of Investigative Dermatology. 124(6):1284-1292
Nuclear factor-kappaB (NF-kappaB) is an inducible nuclear transcription factor regulating a range of cellular processes. An imbalance of the DNA binding activity of NF-kappaB may, therefore, be part of the pathophysiological mechanisms in psoriasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433a6a8a279c6d82f30b0551bc540e8d
Autor:
Henrik Ørum, Majken Westergaard, Yunhe Xu, Zicai Liang, Claes Wahlestedt, Joacim Elmén, Troels Koch, Miriam Frieden, Håkan Thonberg, Karl Ljungberg, Britta Wahren
Publikováno v:
Nucleic Acids Research
Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phenomenon will be dependent on improvements in molecule bio-stability, specificity and delivery. To address these issues, we have systematically modified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c18661c041c529af81603b22b83b44
https://doi.org/10.1093/nar/gki193
https://doi.org/10.1093/nar/gki193
Autor:
Jeanette Henningsen, Claus Johansen, Lars Iversen, Karsten Kristiansen, K. Kragballe, Majken Westergaard
Publikováno v:
Aarhus University
Johansen, C, Kragballe, K, Westergaard, M, Henningsen, J, Kristiansen, K & Iversen, L 2005, ' The mitogen-activated protein kinases p38 and ERK 1/2 are increased in lesional psoriatic skin ', Br. J. Dermatol., vol. 152, no. 1, pp. 37-42 .
Johansen, C, Kragballe, K, Westergaard, M, Henningsen, J, Kristiansen, K & Iversen, L 2005, ' The mitogen-activated protein kinases p38 and ERK 1/2 are increased in lesional psoriatic skin ', Br. J. Dermatol., vol. 152, no. 1, pp. 37-42 .
Summary Background Alterations in specific signal transduction pathways may explain the hyperproliferation and abnormal differentiation of the keratinocytes as well as the increased expression of inflammatory cytokines seen in psoriasis. Major signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e62cf11d83d0e9a76024d00905ce829
https://doi.org/10.1111/j.1365-2133.2004.06304.x
https://doi.org/10.1111/j.1365-2133.2004.06304.x
Autor:
Henrik Daa Schrøder, Morten Lyhne Svendsen, Sofie Rasmussen, Karsten Kristiansen, Uffe Birk Jensen, Bart Staels, Lars Bolund, Knud Kragballe, Jeanette Henningsen, Majken Westergaard, Claus Johansen, Lars Iversen
Publikováno v:
Westergaard, M, Henningsen, J, Johansen, C, Rasmussen, S, Svendsen, M L, Jensen, U B, Schrøder, H D, Staels, B, Iversen, L, Bolund, L, Kragballe, K & Kristiansen, K 2003, ' Expression and Localization of Peroxisome Proliferator-Activated Receptors and Nuclear Factor κB in Normal and Lesional Psoriatic Skin ', Journal of Investigative Dermatology, vol. 121, no. 5, pp. 1104-1117 . https://doi.org/10.1046/j.1523-1747.2003.12536.x
Westergaard, M, Henningsen, J, Johansen, C, Rasmussen, S, Svendsen, M L, Jensen, U B, Schrøder, H D, Staels, B, Iversen, L, Bolund, L, Kragballe, K & Kristiansen, K 2003, ' Expression and localization of peroxisome proliferator-activated receptors and nuclear factor kappaB in normal and lesional psoriatic skin ', Journal of Investigative Dermatology, vol. 121, no. 5, pp. 1104-17 . https://doi.org/10.1046/j.1523-1747.2003.12536.x
Westergaard, M, Henningsen, J, Johansen, C, Rasmussen, S, Svendsen, M L, Jensen, U B, Schrøder, H D, Staels, B, Iversen, L, Bolund, L, Kragballe, K & Kristiansen, K 2003, ' Expression and localization of peroxisome proliferator-activated receptors and nuclear factor kappaB in normal and lesional psoriatic skin ', Journal of Investigative Dermatology, vol. 121, no. 5, pp. 1104-17 . https://doi.org/10.1046/j.1523-1747.2003.12536.x
Udgivelsesdato: 2003-Nov Abnormal epidermal proliferation and differentiation characterize the inflammatory skin disease psoriasis. Here we demonstrate that expression of PPARdelta mRNA and protein is markedly upregulated in psoriatic lesions and tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5265f3b11908cf2bcc7eafbe1f1ad53b
https://doi.org/10.1046/j.1523-1747.2003.12536.x
https://doi.org/10.1046/j.1523-1747.2003.12536.x
Autor:
Majken Westergaard, Knud Kragballe, Jeanette Henningsen, Karsten Kristiansen, Claus Johansen, Lars Iversen
Publikováno v:
Aarhus University
1alpha,25-Dihydroxyvitamin D3 added to human keratinocytes increases differentiation through an activation of the transcription factor activator protein 1. We have previously reported that the 1alpha,25-dihydroxyvitamin D3-induced increase of activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f47df0974a5e9af31fff85876a3858bc
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 22:1607-1609
Full-length and 4 nucleotides truncated Locked Nucleic Acid (LNA) modifications of ISIS 3521 were compared for antisense properties in a cellular assay. ISIS 3521 is a 20-mer phosphorothioate designed to hybridise to human protein kinase C-α (PKC-α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8b68baff9aa2b786401a68f266e663
https://doi.org/10.1081/ncn-120023045
https://doi.org/10.1081/ncn-120023045
Autor:
Majken Westergaard, Lene Sønderby Kjærulff, Christoph Rosenbohm, Henrik Hansen, Henrik Ørum, Jens Bo Hansen, Charlotte Albaek Thrue, Troels Koch, Margit Wissenbach, Niels Fisker
Publikováno v:
Molecular cancer therapeutics. 7(9)
The ability to regulate the cellular homeostasis of a higher organism through tight control of apoptosis and cell division is crucial for life. Dysregulation of these mechanisms is often associated with cancerous phenotypes in cells. Optimal cancer t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a3bc284fe003fda46baf8f2bd0ee4a
https://pubmed.ncbi.nlm.nih.gov/18790754
https://pubmed.ncbi.nlm.nih.gov/18790754
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 26(10-12)
We have investigated the effects of different locked nucleic acid modified antisense mRNA antagonists against Survivin in a prostate cancer model. These mRNA antagonists were found to be potent inhibitors of Survivin expression at low nanomolar conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e9bde364612abac892a141e24c396a
https://pubmed.ncbi.nlm.nih.gov/18066798
https://pubmed.ncbi.nlm.nih.gov/18066798
Autor:
Majken Westergaard, Henrik Frydenlund Hansen, Nikolaj Dam Mikkelsen, Christoph Rosenbohm, Signe M. Christensen, Troels Koch, Miriam Frieden, Henrik Ørum, Charlotte Albaek Thrue
Publikováno v:
Nucleic acids research. 31(21)
Oligonucleotides containing Locked Nucleic Acids (LNA) to various extents and at various positions were evaluated for antisense activity, RNase H recruitment, nuclease stability and thermal affinity. In this work, two different diastereoisomers of LN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83656d73e12547287c6c04be48c38a8
https://pubmed.ncbi.nlm.nih.gov/14576324
https://pubmed.ncbi.nlm.nih.gov/14576324